Publications by authors named "Zhutao Guo"
Article Synopsis
- 5-MeO-AMT is a new psychoactive substance that is gaining attention due to its hallucinogenic and euphoric effects, prompting research into its metabolism.
- In a study involving rats, researchers injected 5-MeO-AMT and analyzed urine samples using advanced mass spectrometry to identify its metabolites.
- Three key metabolites were discovered, with the main metabolic processes identified as O-demethylation, hydroxylation, and acetylation, providing valuable insights for detecting potential toxicity related to 5-MeO-AMT.
Tolfenamic acid is a nonsteroidal anti-inflammatory drug with neuroprotective properties, and it alleviates learning and memory deficits in the APP transgenic mouse model of Alzheimer's disease. However, whether tolfenamic acid can prevent motor and memory dysfunction in transgenic animal models of Huntington's disease (HD) remains unclear. To this end, tolfenamic acid was orally administered to transgenic R6/1 mice from 10 to 20 weeks of age, followed by several behavioral tests to evaluate motor and memory function.
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