Publications by authors named "Zhutao Ding"
Article Synopsis
- The study investigates the role of PIWI-interacting RNAs (piRNAs) and their genetic variants in the risk and progression of prostate cancer (PCa) using data from over 85,000 PCa cases and 166,000 controls.
- A specific genetic variant, rs17201241, is linked to increased expression of PROPER, a piRNA associated with higher risk and severity of PCa, which works by affecting mRNA interactions and promoting cancer progression through the p38 MAPK signaling pathway.
- Targeting PROPER has shown potential in suppressing tumor growth in experimental models, suggesting it could be a valuable target for new PCa treatments.
Genetic variants in super-enhancers (SEs) are increasingly implicated as a disease risk-driving mechanism. Previous studies have reported an associations between benzo[a]pyrene (BaP) exposure and some malignant tumor risk. Currently, it is unclear whether BaP is involved in the effect of genetic variants in SEs on prostate cancer risk, nor the associated intrinsic molecular mechanisms.
View Article and Find Full Text PDFArticle Synopsis
- Polycyclic aromatic hydrocarbons (PAHs), specifically benzo[a]pyrene (BaP), are linked to colorectal cancer (CRC) risk and may affect estrogen receptor beta (ERβ) activity, which is crucial in estrogen-dependent cancers.
- The study found that CRC patients had higher levels of BaP in plasma compared to healthy controls, leading to significant estrogenic effects that could contribute to tumor progression.
- Additionally, genetic variants associated with CRC risk were identified, with one variant disrupting ERβ binding and influencing expression of a related RNA, indicating a complex interaction between environmental factors and genetic predisposition in CRC.
Background: Environmental pollutant measurement is essential for accurate health risk assessment. However, the detection of humans' internal exposure to pollutants is cost-intensive and consumes time and energy. Polygenic risk scores (PRSs) have been widely applied in genetic studies of complex trait diseases.
View Article and Find Full Text PDF