A novel hyperparameter search approach for accuracy and simplicity in disease prediction risk scoring.

Objective: Develop a novel technique to identify an optimal number of regression units corresponding to a single risk point, while creating risk scoring systems from logistic regression-based disease predictive models. The optimal value of this hyperparameter balances simplicity and accuracy, yielding risk scores of small scale and high accuracy for patient risk stratification.

Materials And Methods: The proposed technique applies an adapted line search across all potential hyperparameter values.

An Evaluation of Spin in the Abstracts of Systematic Reviews and Meta-analyses on the Treatment of Psoriasis: A Cross-sectional Analysis.

Spin is a way of reporting that distorts the true findings; we sought to investigate the prevalence of spin in systematic review abstracts on psoriasis treatments and whether study characteristics were associated with spin. We searched MEDLINE and Embase to obtain our sample. Screening and data extraction were performed in a masked duplicate fashion.

BAYESIAN ANALYSIS FOR IMBALANCED POSITIVE-UNLABELLED DIAGNOSIS CODES IN ELECTRONIC HEALTH RECORDS.

With the increasing availability of electronic health records (EHR), significant progress has been made on developing predictive inference and algorithms by health data analysts and researchers. However, the EHR data are notoriously noisy due to missing and inaccurate inputs despite the information is abundant. One serious problem is that only a small portion of patients in the database has confirmatory diagnoses while many other patients remain undiagnosed because they did not comply with the recommended examinations.

The presence of spin in systematic reviews focused on diabetic neuropathy: A cross-sectional analysis.

Background: Spin-the misrepresentation of a study's actual results-has the potential to alter a clinician's interpretation of the study's findings and therefore could affect patient care. Studies have shown spin frequently occurs in abstracts of systematic reviews from a variety of other medical disorders and specialties.

Aims: Our primary aim was to evaluate whether the nine most severe types of spin occurred in systematic review abstracts' concerning diabetic neuropathy treatments.

Evaluation of spin in the abstracts of systematic reviews and meta-analyses relating to postoperative nausea and vomiting.

Introduction: Spin - the beautification of study results to emphasise benefits or minimise harms - is a deceptive reporting strategy with the potential to affect clinical decision-making adversely. Few studies have investigated the extent of spin in systematic reviews. Here, we sought to address this gap by evaluating the presence of the nine most severe forms of spin in the abstracts of systematic reviews on treatments for postoperative nausea and vomiting (PONV).

A brief analysis of challenges in implementing telehealth in a rural setting.

Available literature clearly indicates that successful implementation of telemedicine and telehealth has been a challenge. This challenge is further amplified if the reader must consider this implementation in a rural setting. In this article the authors discuss some of the key challenges associated with this implementation.

Evaluation of Spin in the Abstracts of Systematic Reviews and Meta-analyses Covering Treatments for Achilles Tendon Ruptures.

Background: Approximately 18 in every 100 000 people have experienced a ruptured Achilles tendon. Despite the prevalence of this condition, treatment options remain contested.

Hypothesis/purpose: The objective of this study was to evaluate the use of spin-reporting practices that may exaggerate benefit or minimize harm-in abstracts of systematic reviews related to Achilles tendon repair.

Towards the Development of a Substance Abuse Index (SEI) through Informatics.

Substance abuse or drug dependence is a prevalent phenomenon, and is on the rise in United States. Important contributing factors for the prevalence are the addictive nature of certain medicinal/prescriptive drugs, individual dispositions (biological, physiological, and psychological), and other external influences (e.g.

Spin Infrequently Occurs in Abstracts of Systematic Reviews For The Pharmacological Treatment of Type 2 Diabetes Mellitus.

Aims: Currently, there is a growing body of research demonstrating that spin - the misinterpretation and distortion of a study's findings - is common in different fields of medicine. To our knowledge, no study has investigated its presence in systematic reviews focused on diabetic therapies.

Methods: We performed a cross-sectional study by searching MEDLINE and Embase for systematic reviews focused on pharmacologic treatments for type 2 diabetes mellitus.

Derivation and Validation of Essential Predictors and Risk Index for Early Detection of Diabetic Retinopathy Using Electronic Health Records.

Diabetic retinopathy (DR) is a leading cause for blindness among working-aged adults. The growing prevalence of diabetes urges for cost-effective tools to improve the compliance of eye examinations for early detection of DR. The objective of this research is to identify essential predictors and develop predictive technologies for DR using electronic health records.

Evaluation of spin in the abstracts of systematic reviews and meta-analyses covering surgical management, or quality of life after surgical management, of osteoarthritis of the knee.

Objective: Our primary objective was to identify the prevalence of spin - misleading reporting practices that overemphasize benefit or underemphasize harm - within the abstracts of systematic reviews and meta-analyses focused on surgical management of osteoarthritis of the knee.

Methods: A search string was developed to search Ovid MEDLINE and Ovid Embase for articles pertaining to surgical management, or quality of life after surgical management, of osteoarthritis of the knee. Titles and abstracts were screened according to our protocol, developed , followed by full-text evaluation for spin in included articles.

Readmission Rates After Hip Fracture: Are There Prefracture Warning Signs for Patients Most at Risk of Readmission?

Background: The purpose of this study was to evaluate known and yet unknown risk factors associated with readmission to the hospital within 30 days after hip fracture.

Methods: In this study, we used the Cerner Health Facts Electronic Health Record database data from January to August 2015. The univariate association of each variable (discharge location, demographic details, and comorbidities) against the 30-day readmission status was evaluated using the Chi-square test or the Fisher exact test.

SNP variable selection by generalized graph domination.

Background: High-throughput sequencing technology has revolutionized both medical and biological research by generating exceedingly large numbers of genetic variants. The resulting datasets share a number of common characteristics that might lead to poor generalization capacity. Concerns include noise accumulated due to the large number of predictors, sparse information regarding the p≫n problem, and overfitting and model mis-identification resulting from spurious collinearity.