Publications by authors named "Zhuoyue Fu"
Article Synopsis
- Branching enzymes (BEs) are crucial for modifying α-glucans, which are important energy storage molecules, but their mechanisms, especially regarding substrate binding and transfers (SBTs), are not fully understood from an industrial standpoint.
- The study introduces a new Rhodothermus profundi BE (RpBE) that exhibits double the enzymatic activity compared to the currently used Rhodothermus obamensis BE in industry, highlighting its potential for better applications.
- By leveraging experiments and large-scale computations, the research indicates that optimizing key positions in RpBE can enhance its activity and allow for customization of its products, with efficient substrate-transfer steps being a significant factor in its high performance.
Article Synopsis
- The RNA helicase DDX21, crucial for ribosome production, is found to be increased in colorectal cancer (CRC) but its role in tumor growth is not well understood.
- Research indicates that DDX21 is directly activated by β-catenin, a key player in CRC, and high levels of DDX21 are linked to worse outcomes for patients.
- Loss of DDX21 affects YAP's function, reducing CRC cell growth and movement, and ribosomal stress appears to enhance DDX21 expression through a specific stress response pathway, suggesting new treatment strategies that target ribosomal stress and YAP inhibition.
Background: Rusted root rot is one of the most common root diseases in Panax ginseng, and Cylindrocarpon destructans is one of the main pathogenic fungus. The objective of this study was to screen and explore the extracts of biocontrol bacteria isolated from ginseng rhizosphere soil against Cylindrocarpon destructans.
Results: Bacterial strains Bacillus amyloliquefaciens YY8 and Enterobacteriacea YY115 were isolated and found to exhibit in vitro antifungal activity against C.