Publications by authors named "Zhuoyan Luo"
Article Synopsis
- Oral lichen planus (OLP) is a chronic inflammatory condition of the mouth that may become cancerous, and new research highlights the potential link between microbial imbalances and OLP development.
- The study analyzed the oral microbiota and metabolic profiles of 95 OLP patients compared to 105 healthy individuals using advanced sequencing and metabolomics methods.
- Findings revealed significant differences in microbial diversity and identified specific bacteria and metabolites associated with OLP, suggesting a complex relationship between oral microbiome and metabolism in the disease's progression.
Objective: To understand the gender characteristics of oral lichen planus (OLP) by identifying the gender-specific salivary microbiome and its potential biomarkers.
Methods: A gender-based study was undertaken, commencing with the collection of saliva samples, followed by 16S rRNA gene sequencing, to explore the differences in the composition of saliva microbiome in OLP patients (40 males and 56 females) and healthy controls (40 males and 56 females), respectively.
Results: Both male and female OLP patients had significant differences in saliva microbiome composition from healthy controls, especially in female patients.
Article Synopsis
- Oral squamous cell carcinoma (OSCC) is a common head and neck cancer that is usually diagnosed late, leading to a poor outlook, and recent studies have suggested a link between OSCC and the presence of certain microorganisms in the tumors.
- A review of various studies found that bacteria associated with OSCC show different levels of abundance and diversity, and these bacteria can originate from sources such as oral plaque, saliva, and even the gut, influencing cancer-related processes in both positive and negative ways.
- The presence of these intralesional microbiota plays a crucial role in the progression of OSCC and related disorders, but challenges like inconsistent sampling methods and microbial identification highlight the need for further research to better understand their implications for treatment and
Objectives: Recurrent aphthous ulcer (RAU) is a prevalent oral mucosal disease, affecting around 20% of the global population. It can greatly impair the quality of life for affected individuals. However, the exact etiology of RAU remains unknown.
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