Publications by authors named "Zhuoyan Gong"
Objective: To investigate the efficacy of Jinsiwei (a patented Chinese herbal compound) on learning and memory impairment, the number of synapses and synaptic plasticity-related structural and functional protein expression in mice with sporadic Alzheimer's disease (SAD) induced by streptozotocin.
Methods: Seventy-five C57/BL6J male mice were intracerebroventricularly injected with streptozotocin to establish the animal model of SAD. Mice were randomly divided into the model group (MG), donepezil group (DG), and the Jinsiwei high, medium, and low-dose groups (JH, JM, JL).
Article Synopsis
- Shen-Zhi-Ling oral liquid (SZL) is an herbal treatment aimed at supporting heart and spleen health, specifically targeting early-stage dementia and Alzheimer's disease (AD) through neuroprotective mechanisms related to brain glucose metabolism.
- The study utilized various methods, including LC-MS/MS, behavioral tests on transgenic mice, transmission electron microscopy, and micro-PET imaging, to evaluate SZL's effects on cognitive functions, brain structure, and glucose uptake.
- Results indicated that SZL significantly improved cognitive deficits and reduced pathological damage associated with AD, enhancing glucose transport and signaling pathways (InR/PI3K/Akt) that are crucial for brain health.
Ethnopharmacological Relevance: Shenzhiling oral liquid (SZL), a traditional Chinese medicine (TCM) compound, is firstly approved by the Chinese Food and Drug Administration (CFDA) for the treatment of mild to moderate Alzheimer's disease (AD). SZL is composed of ten Chinese herbs, and the precise therapy mechanism of its action to AD is far from fully understood.
Aim Of The Study: The purpose of this study was to observe whether SZL is an effective therapy for amyloid-beta (Aβ)-induced myelin sheath and oligodendrocytes impairments.