Antibiotic resistance poses a global environmental challenge that jeopardizes human health and ecosystem stability. Antibiotic resistant bacteria (ARB) significantly promote the spreading and diffusion of antibiotic resistance. This study investigated the efficiency and mechanism of inactivating tetracycline-resistant Escherichia coli (TR E.
View Article and Find Full Text PDFOver the past few decades, acetaminophen (ACT), a typical nonsteroidal anti-inflammatory drug (NSAID), has gained global usage, positioning itself as one of the most extensively consumed medications. However, the incomplete metabolism of ACT leads to a substantial discharge into the environment, classifying it as an environmental contaminant with detrimental effects on non-target organisms. Various wastewater treatment technologies have been developed for ACT removal to mitigate its potential environmental risk.
View Article and Find Full Text PDFBiochim Biophys Acta Gene Regul Mech
September 2023
Tudor domain-containing protein 3 (TDRD3) is involved in regulating transcription and translation, promoting breast cancer progression, and modulating neurodevelopment and mental health, making it a promising therapeutic target for associated diseases. The Tudor domain of TDRD3 is essential for its biological functions, and targeting this domain with potent and selective chemical probes may modulate its engagement with chromatin and related functions. Here we reported a study of TDRD3 antagonist following on our earlier work on the development of the SMN antagonist, Compound 1, and demonstrated that TDRD3 can bind effectively to Compound 2, a triple-ring analog of Compound 1.
View Article and Find Full Text PDFThe sluggish kinetics of oxygen evolution reaction (OER) is the bottleneck of alkaline water electrolysis. The urea oxidation reaction (UOR) with much faster kinetics was to replace OER. To further promote UOR, a heterojunction structure assembled of CoS and MoO was established, and then its superior catalytic activity was predicted by DFT calculation.
View Article and Find Full Text PDFThe iridoid glycosides were extracted and separated from seeds, and the potential protective effect of seed extract on concanavalin A-induced immune liver injury in mice was studied. seeds were extracted by 95% ethanol reflux. Then, the iridoid glycosides were enriched by extraction refined through petroleum ether (60°C-90°C), ethyl acetate, and water-saturated n-butanol in sequence, so as to purify the n-butanol part ( seed's n-butanol extraction, OFSN) by macroporous resin.
View Article and Find Full Text PDFPolyhydroxyalkanoate (PHA) producer selection is a key step in mixed culture (MC) production. This study focused on incompatibility between PHA storage and floc settling of MCs in the selection process. In a selector using fermented waste activated sludge as substrate under varying organic loading, average maximum PHA content obtained in batch assays increased by ∼ 22 wt% and biomass concentration increased by ∼ 34% with the increasing of organic loading.
View Article and Find Full Text PDFACS Appl Mater Interfaces
January 2019