Publications by authors named "Zhuoqing Zhuang"
Article Synopsis
- Regulatory T (Treg) cells play a crucial role in preventing autoimmune diseases and tissue rejection by regulating immune tolerance.
- Low-dose Interleukin-2 (IL-2) therapy can enhance Treg cell numbers and functionality, potentially correcting imbalances in the immune response associated with various autoimmune conditions.
- The review discusses the biology of IL-2, its therapeutic mechanisms in several autoimmune diseases (like SLE and Type 1 Diabetes), and future strategies to improve low-dose IL-2 treatment efficacy.
Background: After encountering COVID-19 patients who test positive again after discharge, our study analyzed the pathogenesis to further assess the risk and possibility of virus reactivation.
Methods: A separate microarray was acquired from the Gene Expression Omnibus (GEO), and its samples were divided into two groups: a "convalescent-RTP" group consisting of convalescent and "retesting positive" (RTP) patients (group CR) and a "healthy-RTP" group consisting of healthy control and RTP patients (group HR). The enrichment analysis was performed with R software, obtaining the Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG).