A photo-responsive self-healing hydrogel loaded with immunoadjuvants and MoS nanosheets for combating post-resection breast cancer recurrence.

Tumor recurrence after surgical resection remains a significant challenge in breast cancer treatment. Immune checkpoint blockade therapy, as a promising alternative therapy, faces limitations in combating tumor recurrence due to the low immune response rate. In this study, we developed an implantable photo-responsive self-healing hydrogel loaded with MoS nanosheets and the immunoadjuvant R837 (PVA-MoS-R837, PMR hydrogel) for generation of tumor-associated antigens at the post-surgical site of the primary tumor, enabling sustained and effective activation of the immune response.