Nickel-catalyzed regiodivergent sulfonylarylation of 1,3-enynes to access allenes and dienes.

The radical-mediated difunctionalization of 1,3-enynes facilitates rapid access to structurally diverse allenes and dienes. Whereas, owing to the existence of multiple active sites in conjugated 1,3-enynes, regulating selectivity in difunctionalized addition a single transition-metal-catalyzed radical tandem process remains elusive. Herein, we disclose an intriguing protocol of substrate-controlled nickel-catalyzed regiodivergent sulfonylarylation of 1,3-enynes with the assistance of sulfonyl chlorides and arylboronic acids.

Formal C-H/C-I Metathesis: Site-Selective C-H Iodination of Anilines Using Aryl Iodides.

Functional group metathesis has the potential to render mild reaction conditions for C-H functionalization. Protocols for the - and -C-H iodination of aniline derivatives via formal C(sp)-H/C(sp)-I metathesis using 2-nitrophenyl iodides as mild iodinating reagents are reported herein. These protocols led to the production of a range of valuable iodinated aniline derivatives.