Interactions and asymptotic analysis of N-soliton solutions for the n-component generalized higher-order Sasa-Satsuma equations.

In this paper, we systematically study the N-solitons and asymptotic analysis of the integrable n-component third-fifth-order Sasa-Satsuma equations. We conduct the spectral analysis on the (n+2)-order matrix Lax pair to formulate a Riemann-Hilbert (RH) problem, which is used to generate the N-soliton solutions via the determinants. Moreover, we visually represent the interaction dynamics of multi-soliton solutions and analyze their asymptotic behaviors.

gene frameshift mutations in Alzheimer's disease.

Background: The pathogenic missense mutations of the gelsolin () gene lead to familial amyloidosis of the Finnish type (FAF); however, our previous study identified frameshift mutations existed in patients with Alzheimer's disease (AD). The genotype-phenotype heterogeneity and the role of frameshift mutations in patients with AD are unclear.

Method: In total, 1192 patients with AD and 1403 controls were screened through whole genome sequencing, and 884 patients with AD were enrolled for validation.

Associations of risk genes with onset age and plasma biomarkers of Alzheimer's disease: a large case-control study in mainland China.

Most genetic studies concerning risk genes in Alzheimer's disease (AD) are from Caucasian populations, whereas the data remain limited in the Chinese population. In this study, we systematically explored the relationship between AD and risk genes in mainland China. We sequenced 33 risk genes previously reported to be associated with AD in a total of 3604 individuals in the mainland Chinese population.

Lack of association between LGMN and Alzheimer's disease in the Southern Han Chinese population.

Recently, functional studies have demonstrated that legumain (LGMN) cleaves both amyloid β-protein precursor and tau, promoting senile plaques and formation of neurofibrillary tangles, which may play a crucial role in the pathogenesis of Alzheimer's disease (AD). However, the genetic role of LGMN in AD has not been clearly elucidated. Here, we used Sanger sequencing to investigate the single independent (single-variant association test) and cumulative (gene-based association test) effects of variants in the LGMN gene as potential susceptibility factors for AD, in a cohort comprising 676 AD cases and 365 elderly controls from the Han population of South China.