Publications by authors named "Zhuodong Cui"
Introduction: Porcine reproductive and respiratory syndrome virus (PRRSV) causes reproductive and respiratory diseases in sow herds and piglets. The emergence of ORF5 RFLP 1-7-4-like (NADC34-like) PRRSV strain in China has brought a new round of challenges to PRRSV prevention.
Methods: In addition, recombinant adenovirus vaccine candidates against the newly emerged NADC34-like strain were constructed in the study; the immunogenicity of the vaccine was investigated in piglets.
The Torque teno canis virus (TTCaV) is a small virus with circular single-stranded DNA that has been reported to cause infections in dogs. The present study aimed to identify the presence of TTCaV in blood samples obtained from domestic dogs, and examine its diversity and evolution of the genomes. Five strains of TTCaV were detected, and the overall prevalence was found to be 7% (28/400).
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- The study aimed to investigate how mutations in specific amino acid residues of the NS1 protein affect the pathogenicity of influenza viruses, particularly by examining the protein's virulence-related sites.
- Researchers cloned segments of the NS1 gene from the HIN1 subtype, created mutations at specific amino acids (aa42, aa81, aa149), and tested these mutated strains in chick embryos and mice.
- Results indicated that a mutation at aa42 did not alter pathogenicity, while mutations at aa81 and aa149 reduced the virus's pathogenicity, providing insights for future studies on NS1's role in influenza's disease mechanisms.