Treatment response of venlafaxine induced alterations of gut microbiota and metabolites in a mouse model of depression.

Antidepressants remain the first-line treatment for depression. However, the factors influencing medication response are still unclear. Accumulating evidence implicates an association between alterations in gut microbiota and antidepressant response.

Integrated analysis of transcriptional changes in major depressive disorder: Insights from blood and anterior cingulate cortex.

Background: Major depressive disorder (MDD) was involved in widely transcriptional changes in central and peripheral tissues. While, previous studies focused on single tissues, making it difficult to represent systemic molecular changes throughout the body. Thus, there is an urgent need to explore the central and peripheral biomarkers with intrinsic correlation.

Alterations of the gut microbiota in patients with schizophrenia.

Introduction: Schizophrenia is a complex psychiatric disorder, of which molecular pathogenesis remains largely unknown. Accumulating evidence suggest that gut microbiota may affect brain function via the complex gut-brain axis, which may be a potential contributor to schizophrenia. However, the alteration of gut microbiota showed high heterogeneity across different studies.

Combined Experimental and Density Functional Theory Study on the Mechanism of the Selective Catalytic Reduction of NO with NH over Metal-Free Carbon-Based Catalysts.

Metal-free carbon-based catalysts are attracting much attention in the low-temperature selective catalytic reduction of NO with NH (NH-SCR). However, the mechanism of the NH-SCR reaction on carbon-based catalysts is still controversial, which severely limits the development of carbon-based SCR catalysts. Herein, we successfully reconstructed carbon-based catalysts through oxidation treatment with nitric acid, thereby enhancing their low-temperature activity in NH-SCR.

Uncovering the Dinuclear Mechanism of NO-Involved NH-SCR over Supported VO/TiO Catalysts.

Commercial vanadium oxide catalysts exhibit high efficiency for the selective catalytic reduction (SCR) of NO with NH, especially in the presence of NO (i.e., occurrence of fast NH-SCR).

Integrated pathway and network analyses of metabolomic alterations in peripheral blood of patients with depression.

Depression is a serious mental illness, but the molecular mechanisms of depression remain unclear. Previous research has reported metabolomic changes in the blood of patients with depression, while integrated analysis based on these altered metabolites was still lacking. The objective of this study was to integrate metabolomic changes to reveal the underlying molecular alternations of depression.

Unveiling the Origin of Selectivity in the Selective Catalytic Reduction of NO with NH over Oxide Catalysts.

The trade-off between activity and selectivity is a century-old puzzle in catalysis. In the selective catalytic reduction of NO with NH (NH-SCR), various typical oxide catalysts exhibit distinct characteristics of activity and selectivity: Mn-based catalysts show outstanding low-temperature activity and poor N selectivity, mainly caused by NO formation, while Fe- and V-based catalysts possess inverse characteristics. The underlying mechanism, however, has remained elusive.