Gender-different effect of Src family kinases antagonism on photophobia and trigeminal ganglion activity.

Background: Src family kinases (SFKs) contribute to migraine pathogenesis, yet its role in regulating photophobia behaviour, one of the most common forms of migraine, remains unknown. Here, we addressed whether SFKs antagonism alleviates photophobia behavior and explored the underlying mechanism involving hypothalamus and trigeminal ganglion activity, as measured by the alteration of neuropeptide levels and transcriptome respectively.

Methods: A rapid-onset and injury-free mouse model of photophobia was developed following intranasal injection of the TRPA1 activator, umbellulone.

The nitric oxide synthase gene negatively regulates biofilm formation in .

is a clinically important conditioned pathogen that can cause a troublesome chronic implant-related infection once a biofilm is formed. The nitric oxide synthase () gene, which is responsible for endogenous nitric oxide synthesis, has already been found in the genome of ; however, the specific mechanisms associated with the effects of on pathogenicity are still unknown. The purpose of the current study was to investigate whether the gene has an impact on biofilm formation in .

Chromosomal and Plasmid-Borne Tigecycline Resistance Genes (X3) and (X4) in Dairy Cows on a Chinese Farm.

We isolated 47 strains carrying (X3) and 4 ST767 strains carrying (X4) from 296 rectal swab samples from dairy cows on a Chinese farm. (X3) was located on chromosomes or diverse plasmids, and (X4) was located on IncFIBκ/FIA(HI1)/X1 nontransferable plasmid. The coexistence of (X3) and carbapenemase genes, including and , was detected in 9 spp.