TMEM35B as a novel biomarker for diagnosing gliomas.

Aims: There is little information about transmembrane protein 35B (TMEM35B) expression in glioma, and its functions in glioma remains no clue.

Patients & Methods: Immunohistochemistry was used to measure TMEM35B expression levels and CCK8 and Transwell assays were analyzed the proliferative and migratory and invasive.

Results: TMEM35B protein was significantly higher in gliomas and correlated with a higher tumor TNM stages.

Mean platelet volume/platelet count ratio in combination with tumor markers in colorectal cancer: a retrospective clinical study.

Background: Mean platelet volume (MPV) is a marker of platelet activation, which is usually negatively correlated with platelet count (PC). The ratio of MPV to PC (MPV/PC) has an essential role in the diagnosis of multiple malignancies. However, only a few studies investigated the value of MPV/PC in colorectal cancer (CRC) and the combination of MPV/PC with tumor markers in CRC.

Expressions of EZH2 and NOTCH3 pathway in osteosarcoma and their roles in osteosarcoma stem cells.

Osteosarcoma (OS) is the most common malignant bone tumour; however, the underlying mechanisms are mainly unknown. Enhancer of zeste homologue 2 (EZH2) and NOTCH pathway are important molecular signals related to carcinogenesis and tumour progression, but they are not fully understand in OS. Enhancer of zeste homologue 2, Notch3, HES1, and Nanog were detected on OS samples and statistically analysed.

Pathologic complete response to preoperative immunotherapy in a lung adenocarcinoma patient with bone metastasis: A case report.

Anti-programmed cell death 1 (PD-1) and its ligand (PD-L1) has emerged as a novel immunotherapy for non-small cell lung cancer (NSCLC). However, the proportion of patients who may benefit from immunotherapy is limited and the factors sensitive or resistant to immunotherapy are not completely clear. Therefore, to identify reliable biomarkers as predictors of clinical response and resistance to anti-PD-1/PD-L1 therapies have become increasingly important.

Identification of Different Form Tim-3 Proteins by a Unique Set of Tim-3 Monoclonal Antibodies.

T-cell immunoglobulin and mucin domain-3 (Tim-3) has been suggested to be a critical immune checkpoint target for cancer immunotherapy. However, limited progress with Tim-3 immunotherapy has been achieved over the last decade due to the lack of specific Tim-3 monoclonal antibodies. In this study, we have successfully developed a unique set of Tim-3 antibodies that are able to detect different molecular weights (by Western blot mobility) of Tim-3 proteins ectopically expressed in the same CHO cells.

Case report: metastases from thyroid and nasopharyngeal carcinomas in the same lymph node following chemotherapy for mantle cell lymphoma.

We report a case of metastatic papillary thyroid carcinoma and undifferentiated nonkeratinizing nasopharyngeal carcinoma to the same cervical lymph node following chemotherapy for mantle cell lymphoma. Total thyroidectomy, right cervical nodal dissection, radioactive iodine-131 therapy and radiotherapy to the nasopharynx and the neck resulted in remission of both tumors. No recurrence was noted in follow-up for 48 months.

[Pulmonary epithelioid hemangioendothelioma: a clinicopathological analysis].

Objective: To report 3 cases of pulmonary epithelioid haemangioendothelioma (PEH) and therefore to improve the understanding of this tumor.

Methods: The clinical pathological features of 3 cases of PEH were described and related literatures were reviewed.

Results: The etiology of this rare disease remained unknown.

Extraction of prostatic lumina and automated recognition for prostatic calculus image using PCA-SVM.

Identification of prostatic calculi is an important basis for determining the tissue origin. Computation-assistant diagnosis of prostatic calculi may have promising potential but is currently still less studied. We studied the extraction of prostatic lumina and automated recognition for calculus images.

Primary malignant bone neoplasm: a case report of dedifferentiated chondrosarcoma in the rib and review of the literature.

Dedifferentiated chondrosarcoma (DDCS) is a rare but highly malignant primary bone neoplasm, which is resistant to radiotherapy and chemotherapy. There remains uncertainly as to the best treatment of this disease and how to improve its prognosis. In this paper we reported a case of DDCS and reviewed the related literatures in order to provide references to throw a light on the histogenesis, diagnosis and therapy of this disease.

[Pathological and ultramicrostructural changes of tissues in a patient with severe acute respiratory syndrome].

Objective: To study the morphological, ultramicrostructural and pathological changes of tissues from a patient with severe acute respiratory syndrome (SARS).

Methods: One autopsy case of diagnosed SARS was investigated. Lung puncture was performed immediately after the patient died, and the autopsy was done after 12 h.