Publications by authors named "Zhuo-jun Zhang"

Subsequently to the publication of the above article, an interested reader drew to the authors' attention that a possible error had been identified in the selection of images in Figs. 1 and/or 7. After having consulted their original data, the authors realized that an erroneous image appeared on p.

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  • Clinical studies link high uric acid levels (hyperuricemia) to cardiovascular diseases, but the mechanisms are unclear; this study investigates how uric acid affects heart cells (cardiomyocytes).
  • H9c2 cardiomyocytes exposed to varying uric acid levels showed increased expression of genes related to heart enlargement (hypertrophy) and changes in cell surface area, with autophagy both being activated and mitigated by specific inhibitors.
  • The study concludes that uric acid causes heart cell enlargement through autophagy activation via the AMPK-ULK1 pathway, suggesting that lowering uric acid levels could help reduce heart hypertrophy in patients.
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The prevalence of coronary artery disease (CAD) is growing in the young population. We aimed to investigate the association between serum uric acid (SUA) levels and cardiovascular involvement in individuals under 45 years old diagnosed with early-onset CAD (EOCAD). Seven hundred eighty-six EOCAD patients were recruited and stratified into four groups by SUA levels.

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Soil ingestion is an important human exposure pathway for lead (Pb). A modified physiologically based extraction test was applied to 70 soil samples from five battery plants in East China. The mean values for soil pH, soil organic matter, Fe and Mn concentrations ranged from 5.

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Macrophages are a major component of the leukocyte infiltrate of tumors and play a pivotal role in the progression of hepatocellular carcinoma (HCC). However, the molecular mechanisms by which macrophages promote HCC invasion are poorly understood. The present study was undertaken to investigate the relationship between macrophages and epithelial-mesenchymal transition (EMT) of HCC.

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Objective: To investigate the variation of human breast milk adiponectin (APN) concentration during lactation, analyze the relationship of APN concentrations in human breast milk with APN in infant serum, determine the association between maternal milk APN and infant body proportionality in the first year of life, and the period of greatest human milk exposure.

Method: Subjects included 73 mother-infant pairs from Shanghai International Peace Maternity & Child Health Hospital. Maternal milk was collected at 2, 4, 13, 26 weeks and infant serum was collected at 26 weeks.

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  • The study aimed to examine the structure of lymph vessels in gastric cancer tissues and how it relates to cancer spread (metastasis).
  • Researchers analyzed tissues from 32 gastric cancer cases, noting morphological changes in lymph vessels and capillaries.
  • Findings indicated that lymph vessels in cancerous areas showed larger sizes and that swollen lymph vessels help cancer cells spread, particularly through well-formed lymph capillaries in nearby tissues.
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