[Apelin attenuates hypoxia induced pulmonary hypertension of mice through regulation of lipid metabolism].

Objective: To observe the role of apelin in the prevention of pulmonary hypertension induced by hypoxia in mice.

Methods: Adult male apoE gene knockout (apoE-KO) mice were exposed to isobaric hypoxic chamber (9%~11% O, regular chow feed, 23 h/d)for 3 weeks to establish hypoxia-induced pulmonary hypertension. Thirty apoE-KO mice were randomly divided into normoxia group, hypoxia group and hypoxic with apelin (10 nmol/(kg·d), ip) group.