Publications by authors named "Zhuo Zhang"

Background: Comparing the impact of different educational modes on medical students' performance under the scoring criteria for multiple-choice questions, would provide a basis for selecting more appropriate and effective teaching modes for talent development.

Methods: We searched databases such as CNKI, Wanfang, PubMed, and Web of Science to collect publications on the comparison of medical students' performance under the scoring criteria for multiple-choice questions and different teaching modes, with a focus on studies conducted between 2015 and 2024. Chinese search terms included multiple-choice questions, multiple-choice exam, medical students, flipped classroom, simulation teaching, team-based learning, and blended teaching.

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Rapid and accurate prediction of rice Cd (rCd) and rice As (rAs) bioaccumulation are important for assessing the safe utilization of rice. Currently, there is lack of comprehensive and systematic exploration of the factors of rCd and rAs. Herein, ensemble learning (EL) was first used to analysis the 23 factors in 8 categories (heavy metal pollution characteristics, soil properties, geographical characteristics, meteorological factors, socio-economic factors, environmental factors, rice type, and nutrient element) in typical regions of China based on the results of 193 research papers from 2000 to 2024 in Web of Science database.

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SIRT2 (sirtuin2) is a NAD-dependent deacetylase implicated in fibrosis and inflammation of the liver, kidney, and heart. In this study, we designed and synthesized a series of 3-naphthylthiophene derivatives and evaluated their inhibitory activity against the SIRT2 enzyme. Among them, Z18 demonstrated outstanding SIRT2 inhibitory activity and selectivity.

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Chiral hybrid metal halides have received considerable attention in circularly polarized luminescence and spintronics due to their structural diversity, ease of synthesis, and chemical versatility. However, only a limited number of chiral metal halides have been utilized in piezoelectric energy harvesters and motion sensors. Furthermore, the exploration of 0D chiral piezoelectric materials is still in their early stage, offering substantial potential for further development.

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Article Synopsis
  • * One hundred participants were divided into two groups to compare the effects of blended MBSR with standard care, showing significant improvements in the MBSR group over a 12-week period.
  • * The findings suggest that reductions in perceived stress and anxiety are key factors that improve diabetes self-efficacy, which in turn enhances diabetes self-management, while depressive symptoms did not play a mediating role.
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This study investigated the effects of adding 4-20 % Tartary buckwheat protein (TBP, with a purity of 93.35 %) on the structural, thermal, and digestive properties of Tartary buckwheat starch (TBS) by high moisture (60 %) extrusion. The added TBP embedded and enwrapped the starch matrix, which formed protein-starch complexes.

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Due to its sea urchin-like structure, Schwertmannite is commonly applied for heavy metals (HMs) pollutant adsorption. The adsorption influence parameters of Schwertmannite are numerous, the traditional experimental enumeration is powerless. In recent years, machine learning (ML) has been gradually employed for adsorbent materials, but there is no comprehensive research on the Schwertmannite adsorbent.

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Climate can shape plant genetic diversity and genetic structure, and genetic diversity and genetic structure can reflect the adaptation of plants to climate change. We used rbcl and trnL-trnF sequences to analyze the genetic diversity and genetic structure of under the influence of different environmental factors in Inner Mongolia grassland. The results showed that the genetic diversity of this species was low.

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Article Synopsis
  • Ixeris chinensis is a plant known for its edible and medicinal properties, especially featuring anti-inflammatory effects, but specific details about its bioactive compounds have been limited.
  • A detailed phytochemical analysis led to the identification of 31 sesquiterpene lactones (SLs), with 7 being new discoveries and 16 being reported for the first time; primarily, Ixerisoside A was found to be the most abundant.
  • Several SLs demonstrated the ability to inhibit nitric oxide production and suppress inflammatory markers in lab tests, indicating their potential for use in treating inflammatory diseases and as functional foods in the nutraceutical sector.
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Energy harvesting plays an important role in advancing personalized wearables by enabling continuous monitoring, enhancing wearable functionality and facilitating sustainable solutions. We aimed to develop a flexible piezoelectric energy harvesting system based on inorganic piezoelectric materials that convert mechanical energy into electricity to power a wide range of mobile and portable electronic devices. There is significant interest in flexible piezoelectric energy harvesting systems that use inorganic piezoelectric materials due to their exceptional physical features and prospective applications.

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Macrophages are crucial in the heart's development, function, and injury. As part of the innate immune system, they act as the first line of defense during cardiac injury and repair. After events such as myocardial infarction or myocarditis, numerous macrophages are recruited to the affected areas of the heart to clear dead cells and facilitate tissue repair.

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Melanoma treatment remains a challenge due to the inadequacy of existing clinical approaches and the difficulty of tissue regeneration. Recently, microneedles have been widely studied in tumor therapy and skin repair. Hence, a hyaluronic acid (HA)-based dual-functional hydrogel microneedle (MN) system was constructed to sequentially achieve tumor ablation and skin regeneration.

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Cancer is a leading cause of global morbidity and mortality. Tumor cells grow in a complex microenvironment, comprising immune cells, stromal cells, and vascular cells, collaborating to support tumor growth and facilitate metastasis. Transforming growth factor-beta (TGF-β) is a multipotent factor that can not only affect fibrosis promotion but also assume distinct roles in the early and late stages of the tumor.

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Bioinspired piezoelectric amino acids and peptides are attracting attention due to their designable sequences, versatile structures, low cost, and biodegradability. However, it remains a challenge to design amino acids and peptides with high piezoelectricity. Herein, a high piezoelectric amino acid by simple fluorination in its side chain is presented.

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Heavy metals (HMs) represent a persistent and significant threat to aquatic ecosystems. Hydroxyapatite (HAp) has emerged as a utilized material in the remediation of environmental HMs, owing to its exceptionally high porosity, expansive surface area, and the presence of three-dimensional ordered channels. An in-depth study of the synthesis strategy of HAp and its adsorption properties can help reduce the cost of remediating HMs in aquatic environments and alleviate the water shortage.

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Article Synopsis
  • - Cocaine abuse disrupts the blood-brain barrier (BBB) by decreasing the expression of glucose transporter 1 (GLUT1) in brain cells, which leads to cognitive issues and increased BBB leakage.
  • - The study reveals that cocaine elevates the level of miR-320a, which then reduces GLUT1 expression through the activation of the beta 2-adrenergic receptor (ADRB2).
  • - Melatonin can help counteract cocaine-induced BBB disruption and cognitive impairment by boosting GLUT1 expression through a specific signaling pathway, suggesting it could be a potential treatment for cocaine-related problems.
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Glucose metabolism has been well understood for many years, but some intriguing questions remain regarding the subcellular distribution, transport, and functions of glycolytic metabolites. To address these issues, a living cell metabolic monitoring technology with high spatiotemporal resolution is needed. Genetically encoded fluorescent sensors can achieve specific, sensitive, and spatiotemporally resolved metabolic monitoring in living cells and in vivo, and dozens of glucose metabolite sensors have been developed recently.

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A Ru(II)-catalyzed migratory insertion of carbene into C-H bonds of 4-aryl-pyrrolo[2,3-]pyrimidines has been developed. This transformation endows the facile fabrication of C-C bonds with high atom economy, good regioselectivity, and wide functional group tolerance, exploiting the directing properties of pyrimidinic nitrogen. In addition, the planar polycyclic pyrrolo-pyrimido-isoindole framework has been accomplished from a cascade reaction of bromination, cyclization, and decarboxylation of synthesized products.

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Acute lung injury (ALI) is a common critical respiratory disease in clinical practice, especially in the ICU, with a high mortality rate. The pathogenesis of ALI is relatively complex, mainly involving inflammatory response imbalance, oxidative stress, cell apoptosis, and other aspects. However, currently, the treatment measures taken based on the above mechanisms have not had significant effects.

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Article Synopsis
  • Etomidate is a synthetic anesthetic that enhances GABA's effects, making it effective for inducing sleep with advantages like stability in blood pressure and minimal lung impact.
  • Despite its benefits, limitations such as low solubility, adrenal inhibition, and muscle spasms restrict its use, prompting research into improved delivery methods.
  • This review emphasizes the need for better etomidate formulations and administration strategies to overcome these issues and broaden its application in clinical settings.
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