Publications by authors named "Zhuo Tong"

Developing visible-light response photocatalysts with high activity and adsorption alongside sustainability is vitally important to environmental restoration. Here, we fabricated a novel metal organic framework (MOF) with cost-effective double-ligands (fumaric acid and 2-aminoterephthalic acid as ligand precursors, denoted as MA-MOF) via a facile solvothermal method. Specifically, crystalline [ZrO(OH)(fumarate)] (MOF-801) can be only formed with monocarboxylic acids as modulators.

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is a major foodborne parasite worldwide. After the encapsulated muscle larvae (ML) in meat are ingested, the ML are liberated in the stomach of the host and activated into intestinal infectious larvae (IIL), which develop into adult worm after molting four times. A novel glutamine synthetase (TsGS) was identified from IIL at 10 h post-infection, but its biological role in life cycle is not clear.

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Article Synopsis
  • The activation of Trichinella spiralis larvae from muscle larvae (ML) to intestinal infective larvae (IIL) is crucial for infection, with IIL’s excretory/secretory (ES) proteins playing a key role in interacting with the host.
  • The study aimed to identify natural active proteases in T. spiralis IIL ES proteins using techniques like Western blot and LC-MS/MS, discovering significant proteolytic activities that assist in tissue invasion.
  • A total of 30 proteins were identified, mainly serine proteinases, and the higher expression of certain protease genes at the IIL stage suggests their involvement in the parasite's invasion of the host's intestines and evasion of immune responses.
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Molting is a key step for body-size expansion and environmental adaptation of parasitic nematodes, and it is extremely important for Trichinella spiralis growth and development, but the molting mechanism is not fully understood. In this work, label-free LC-MS/MS was used to determine the proteome differences between T. spiralis muscle larvae (ML) at the encapsulated stage and intestinal infective larvae (IIL) at the molting stage.

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