Fluorinated Cyclodextrin Supramolecular Nanoassembly Enables Oxygen-Enriched and Targeted Photodynamic Therapy.

Photodynamic therapy has become a promising treatment modality against many diseases, but its dilemma-the intrinsic hypoxia of solid tumors and the high oxygen dependence for generation of cytotoxic species-has seriously hampered its practical translation. Herein a binary supramolecular nanocarrier, which is composed of fluorocarbon chain-appended β-cyclodextrin as an oxygen carrier and adamantane-grafted hyaluronic acid as a cell-targeting agent, can deliver different types of photosensitizers by multiple noncovalent interactions. Superior to the alkylated counterpart, the fluorinated amphiphilic β-cyclodextrin can spontaneously form a nanoparticulate assembly and exhibit high oxygen-enrichment performance.

In Situ NADH-Activated BODIPY-Based Macrocyclic Supramolecular Photosensitizer for Chemo-Photodynamic Synergistic Tumor Therapy.

Photodynamic therapy (PDT) based on supramolecular assembly has been receiving wide attention due to its great potential application in clinical treatment. Herein, we report a supramolecular photoelectron "reservoir" (SPR) constructed by tetracationic boron dipyrromethene (BODIPY)-based macrocycle (4Cl), doxorubicin (Dox), and tumor-targeted β-cyclodextrin-grafted hyaluronic acid (HACD). Upon irradiation, 4Cl can in situ catalyze nicotinamide adenine dinucleotide (NADH) to continuously generate electrons to inject into SPR, which further transfers electrons to oxygen, inducing highly efficient hydroxyl radical generation even under hypoxia.

The application of multilayered three-dimensional costal cartilage framework in auricular reconstruction with expanded postauricular skin flap.

Background: This study introduces a construction method for a multilayered three-dimensional costal cartilage auricular framework and retrospectively analyzed its clinical effectiveness in auricular reconstruction with an expanded postauricular skin flap.

Methods: We designed multiple techniques for constructing a multilayered three-dimensional costal cartilage auricular framework to enhance stability and aesthetic outcomes. Postoperative follow-up included a comprehensive morphological assessment of the reconstructed ears, as well as evaluations of postoperative complications and patient satisfaction.

Wind Turbine Blade Fault Detection Method Based on TROA-SVM.

Wind turbines are predominantly situated in remote, high-altitude regions, where they face a myriad of harsh environmental conditions. Factors such as high humidity, strong gusts, lightning strikes, and heavy snowfall significantly increase the vulnerability of turbine blades to fatigue damage. This susceptibility poses serious risks to the normal operation and longevity of the turbines, necessitating effective monitoring and maintenance strategies.

Polycationic γ-Cyclodextrin with Amino Side Chains for a Highly Efficient Anti-Heparin Coagulant.

Multicharged cyclodextrins have attracted significant attention because of their applications in biology and pharmaceuticals. This study reports an aminoethoxy-phenyl-pyridinium-modified γ-cyclodextrin (PyA-γ-CD) as a highly efficient coagulant for heparin through multivalent interactions. The UV titration experiment is performed to obtain apparent binding constants (K) between PyA-γ-CD and heparin as high as 9.

Supramolecular Organic Framework that Enables Multifunctional Doxorubicin Delivery, Photofrin Post-treatment Phototoxicity Inhibition, and Heparin Neutralization.

Although porous frameworks are structurally ideal for the development of biomaterials through drug adsorption, sequestration, and delivery, integration of multiple biofunctions into a biocompatible porous framework would greatly improve its potential for preclinical investigations by increasing both therapeutic value and research and development efficiency. Herein, we report the preparation of a highly biocompatible supramolecular organic framework from an imidazolium-derived tetrahedral monomer and cucurbit[8]uril. The supramolecular organic framework has been revealed to have regular intrinsic porosity and adsorb doxorubicin, photofrin, and heparins driven by hydrophobicity and/or ion-pairing electrostatic interactions.

Tunable Nano-Supramolecules Based on Cucurbiturils for Near-Infrared Phosphorescence Imaging.

Nano-supramolecules based on artificial macrocycles can not only regulate assembly morphology but also boost phosphorescence resonance energy transfer (PRET). Herein, a water-soluble phosphorescence supramolecule was constructed from the hyaluronic acid-modified bromophenylpyridinium (HAPY), cucurbit[]uril (CB[], = 7/8), and energy acceptor phenyl-bridged phenothiazine derivatives, displaying efficient PRET and achieving near-infrared (NIR) phosphorescence by macrocyclic CB[] and the assembly confinements. As compared with weak phosphorescent nanofibers of HAPY/CB[7], the spherical nanoparticles of HAPY/CB[8] not only gave strong green phosphorescence with extended lifetime to 1.

Identifying individual's distractor suppression using functional connectivity between anatomical large-scale brain regions.

Distractor suppression (DS) is crucial in goal-oriented behaviors, referring to the ability to suppress irrelevant information. Current evidence points to the prefrontal cortex as an origin region of DS, while subcortical, occipital, and temporal regions are also implicated. The present study aimed to examine the contribution of communications between these brain regions to visual DS.

MicroRNA‑203a‑3p improves bleomycin and pingyangmycin sensitivity by inactivating the PI3K/AKT pathway in hemangioma.

MicroRNAs (miRs) have been found to play a fundamental role in the pathology and progression of hemangioma. Of note, miR-203a-3p prevents hemangioma progression via inactivation of the PI3K/AKT pathway. Bleomycin and pingyangmycin are drugs used in sclerotherapy, but certain hemangioma patients experience drug resistance, leading to poor clinical outcomes.

Deep asymmetric extraction and aggregation for infrared small target detection.

Infrared small target detection is widely applied in military and civilian fields. Due to the small size of infrared targets, textural detail is missing. Common target detection methods extract semantic feature by narrowing down the feature map several times, which may lead to the small targets lost in deep layers and are not effective for infrared small target detection.

MicroRNA‑203a‑3p suppresses endothelial cell proliferation and invasion, and promotes apoptosis in hemangioma by inactivating the VEGF‑mediated PI3K/AKT pathway.

Our previous study demonstrated that microRNA-203a-3p (miR-203a-3p) was involved in the regulation of long non-coding RNA MEG8-mediated the progression of hemangioma, which is a benign tumor characterized by endothelial hyperplasia in the blood vessels and primarily occurring in infants and females. Therefore, the present study aimed to further investigate the effects of miR-203a-3p on endothelial cell proliferation, invasion and apoptosis, as well as its underlying mechanism in hemangioma. Human hemangioma endothelial cells (HemECs) were first transfected with either miR-203a-3p mimics or a miR-203a-3p inhibitor.

Knockdown of inhibits cell proliferation and invasion, but promotes cell apoptosis in hemangioma, via ‑induced mediation of the Notch signaling pathway.

As a member of the long non‑coding (lnc)RNA family, lncRNA maternally expressed 8, small nucleolar RNA host gene (), has been reported to serve an oncogenic role in several types of malignancies, including hepatocellular carcinoma, non‑small cell lung cancer and pancreatic cancer. The current study aimed to investigate the effect of the knockdown of on human hemangioma endothelial cell (HemEC) proliferation, apoptosis and invasion, in addition to determining the underlying molecular mechanism. The knockdown of was achieved by transfecting small interfering (si)RNA into HemECs, while the combined knockdown of knockdown and microRNA (miR)‑203 was established by co‑transfecting siRNA and a miR‑203 inhibitor into HemECs.

Insights into the Mechanism of -Hexane Reforming over a Single-Site Platinum Catalyst.

We demonstrate that the single-site catalyst Pt/CeO greatly enhances the selectivity of cyclization and aromatization in the -hexane reforming reaction. Specifically, the selectivity of single-site Pt/CeO toward both cyclization and aromatization is above 86% at 350 °C. The turnover frequency of Pt/CeO is 58.

Progress in the studies on the role of antisense long chain noncoding RNA in tumor development.

Antisense long chain noncoding RNA (lncRNA) is a new class of RNA molecules. In recent years, antisense lncRNA has been found to play an important role in many life activities including tumorigenesis and development. It has become a hot topic in biological research in recent years.

miR-874-3p inhibits cell migration through targeting RGS4 in osteosarcoma.

Background: The present study explored the role and mechanism of microRNA-874-3p (miR-874-3p) in the migration of the osteosarcoma cell line, U-2 OS.

Methods: The expression profile of osteosarcoma (OS) microRNA (GSE65071) datasets was downloaded from the Gene Expression Omnibus (GEO) database (https://www.ncbi.

Knockdown of LncRNA Inhibits Cell Migration, Invasion and Proliferation in Head and Neck Squamous Cell Carcinoma.

Previous studies have revealed that long non-coding RNAs (lncRNAs) are involved in head and neck squamous cell carcinoma (HNSCC) progression. However, the detailed roles of lncRNA remain to be elucidated. In this study, by analyzing online RNA-Seq data, we found that was upregulated in HNSCC tissues and that its expression level was associated with neoplasm histologic grade.

Antioxidant and Anti-inflammatory Capacity of Ferulic Acid Released from Wheat Bran by Solid-state Fermentation of Aspergillus niger.

Objective: A strain of Aspergillus niger (A. niger), capable of releasing bound phenolic acids from wheat bran, was isolated. This strain was identified by gene sequence identification.

Upregulated Expression of Long Non-Coding RNA, LINC00460, Suppresses Proliferation of Colorectal Cancer.

Through bioinformatics analysis, a novel lncRNA, LINC00460, was implicated in the development of multiple cancers. However, the precise expression pattern, clinical significance and biological function of LINC00460 in colorectal cancer (CRC) remain unknown. Network databases were used to investigate the correlation between LINC00460 and CRC.

Assessment of personal noise exposure of overhead-traveling crane drivers in steel-rolling mills.

Background: Noise is widespread occupational hazard in iron and steel industry. Overhead-traveling cranes are widely used in this industry, but few studies characterized the overhead-traveling crane drivers' noise exposure level so far. In this study, we assessed and characterized personal noise exposure levels of overhead-traveling crane drivers in two steel-rolling mills.

[Measurement of personal noise exposure in a cold rolling mill].

Objective: To measure and evaluate the personal noise exposure of cold rolling mill workers by using noise dosimeter.

Methods: According to job category and work type, all workers were divided into 11 groups. 3 to 5 day shift (8:00 to 16:00) workers from each group were selected as subjects for personal noise exposure measurement.