FOXO4-SP6 axis controls surface epithelium commitment by mediating epigenomic remodeling.

Proper development of surface epithelium (SE) is a requisite for the normal development and function of ectodermal appendages; however, the molecular mechanisms underlying SE commitment remain largely unexplored. Here, we developed a KRT8 reporter system and utilized it to identify FOXO4 and SP6 as novel, essential regulators governing SE commitment. We found that the FOXO4-SP6 axis governs SE fate and its abrogation markedly impedes SE fate determination.

Ionic Liquid Reinforcing Ether Coordination of Localized High Concentration Electrolyte Enables High-Voltage Lithium Metal Batteries.

The decomposition of 1,2-dimethoxyethane (DME) in localized high-concentration electrolytes (LHCEs) under high voltage produces fragile and unstable organic fragments at the cathode/electrolyte interphase, which greatly damages the cycling performance of high-energy-density lithium metal batteries. Herein, a robust strategy is proposed by adding ionic liquid of 1-Methyl-1-propyl pyrrolidinium bis(trifluoromethanesulfonyl)imide (PyrTFSI) as co-solvent into the bulk electrolyte to significantly improve the stability of solvated DME through reinforcing the ion-dipole interaction between TFSI and DME. The PyrTFSI can balance the interaction among the electrolyte components to reduce the dynamic de-coordinated DME molecules and promote the formation of anion-derived cathode electrolyte interphase with excellent electrochemical stability and high Li transport dynamics.

Dynamic Processes of Parent-Adolescent Conflict and Warmth in Chinese Families: Differences between Mothers and Fathers.

Parent-adolescent relationships are shaped by daily interactions that include both warmth and conflict, yet most research has focused on aggregate or long-term patterns rather than their day-to-day fluctuations. Guided by family systems theory, this study examined how mothers and fathers distinctly contribute to daily parent-adolescent warmth and conflict, as well as how these interactions vary across families. The sample consisted of 307 Chinese adolescents (M = 13.

Spillover of Daily Parenting Experiences Into Interparental Relationships in Chinese Families of Children With Autism: Mediated by Daily Affect and Moderated by Trait Mindfulness.

Parenting a child with autism spectrum disorder (ASD) can be stressful for parents, posing unique challenges not only in their relationships with the child but also in their relationships with each other. The present study examined the daily spillover of parenting experiences (i.e.

Short- and long-term outcomes of neoadjuvant chemotherapy compared with neoadjuvant chemoradiotherapy for locally advanced rectal cancer: an updated meta-analysis.

Background And Purpose: Neoadjuvant chemoradiotherapy (NACRT) is the standard treatment regimen for locally advanced rectal cancer (LARC) but has unavoidable radiation toxicity. With the advent of more optimized chemotherapy regimens, neoadjuvant chemotherapy (NAC) is sometimes offered as an alternative to NACRT. The purpose of this meta-analysis was to compare the short- and long-term outcomes of NAC and NACRT for LARC patients.

Dyadic examination of rumination and depressive symptoms in Chinese heterogeneous young couples: the differential role of gender.

Introduction: The relationship between rumination and depressive symptoms has been extensively studied over the past two decades. However, few studies have explored how rumination contributes to depressive symptoms within the context of heterogeneous romantic relationships, particularly regarding potential gender differences in these effects. The present study aims to investigate whether rumination is related to four key factors of depressive symptoms (i.

Deciphering the dynamic single-cell transcriptional landscape in the ocular surface ectoderm differentiation system.

The ocular surface ectoderm (OSE) is essential for the development of the ocular surface, yet the molecular mechanisms driving its differentiation are not fully understood. In this study, we used single-cell transcriptomic analysis to explore the dynamic cellular trajectories and regulatory networks during the differentiation of embryonic stem cells (ESCs) into the OSE lineage. We identified nine distinct cell subpopulations undergoing differentiation along three main developmental branches: neural crest, neuroectodermal, and surface ectodermal lineages.

Expression, prognosis, immunological infiltration, and DNA methylation of members of the SFRP gene family in colorectal cancer: a comparative bioinformatic and experimental analysis.

This study aimed to investigate the expression, prognostic significance, methylation, and immune invasion levels of secreted frizzled-related proteins (SFRP1-5) in colorectal cancer (CRC). Additionally, the relationship between SFRP1/2 methylation and immune infiltration in CRC was explored. The expression of SFRP1-5 was analyzed using several databases, including GEO, TCGA, TIMER, STRING, and GEPIA.

Retinoic acid drives surface epithelium fate determination through the TCF7-MSX2 axis.

Understanding how embryonic progenitors decode extrinsic signals and transform into lineage-specific regulatory networks to drive cell fate specification is a fundamental, yet challenging question. Here, we develop a new model of surface epithelium (SE) differentiation induced by human embryonic stem cells (hESCs) using retinoic acid (RA), and identify BMP4 as an essential downstream signal in this process. We show that the retinoid X receptors, RXRA and RXRB, orchestrate SE commitment by shaping lineage-specific epigenetic and transcriptomic landscapes.

Phase II study of perioperative camrelizumab and XELOX for locally advanced gastric or gastroesophageal junction adenocarcinoma.

Immune checkpoint inhibitors combined with chemotherapy have shown promising efficacy in treating gastric or gastroesophageal junction (G/GEJ) adenocarcinoma in the neoadjuvant setting. This phase II trial (NCT05715632) aimed to investigate the efficacy and safety of perioperative camrelizumab plus XELOX in patients with locally advanced G/GEJ adenocarcinoma. Treatment-naive patients with cT3-4aN1-3 M0 resectable locally advanced G/GEJ adenocarcinoma were recruited to receive camrelizumab (200 mg, intravenously) on Day 1 combined with XELOX (oxaliplatin at 130 mg/m on Day 1 and capecitabine at 1000 mg/m on Days 1-14) every 3 weeks for four cycles, followed by surgery and adjuvant camrelizumab combined with XELOX every 3 weeks for four cycles.

The Impact of Emotion Network Density on Psychological Distress in Chinese Parents of Children with Autism: A Daily Diary Study.

Parents of children with autism often experience a wide range of emotions in their daily lives. However, previous research has primarily focused on average levels of emotional challenges, neglecting the significance of daily emotion dynamics that may underlie parental psychological functioning. This study adopted a dynamic network approach to examine the strength of temporal connections within and between various emotions-referred to as emotion network density-and further explore its impacts on parental psychological distress.

Gr-1 blockade remodels the immunosuppressive microenvironment induced by incomplete microwave ablation of hepatocellular carcinoma.

Background: Ablation is one of the main methods for local treatment of hepatocellular carcinoma (HCC). Different from radiofrequency ablation (RFA), microwave ablation (MWA) is not limited by tissue conductivity, and can use multiple electrodes at the same time to improve ablation efficiency. In addition, MWA can form a larger ablation area, which makes it possible to completely ablate large HCC.

Older is order: entropy reduction in cortical spontaneous activity marks healthy aging.

Background: Entropy trajectories remain unclear for the aging process of human brain system due to the lacking of longitudinal neuroimaging resource.

Results: We used open data from an accelerated longitudinal cohort (PREVENT-AD) that included 24 healthy aging participants followed by 4 years with 5 visits per participant to establish cortical entropy aging curves and distinguish with the effects of age and cohort. This reveals that global cortical entropy decreased with aging, while a significant cohort effect was detectable that people who were born earlier showed higher cortical entropy.

Psychometric properties of the situational procrastination scale of medical undergraduates: factor structure, reliability, and validity.

Introduction: Procrastination is very common among college students, but there is a lack of consistency in the relationship between procrastination and academic achievement, which might be partly caused by the limitations of previous procrastination scales. The current study constructed the Situational Procrastination Scale (SPS) with two subscales, the Academic Situational Procrastination Scale (ASPS) and the Daily Life Situational Procrastination Scale (DSPS), by adapting previous procrastination scales.

Method: The valid sample for data analysis included 2,094 medical undergraduates.

Implications of respiratory sinus arrhythmia (RSA) inertia for child psychopathology: Direct effect and interaction with between-task RSA reactivity.

Respiratory sinus arrhythmia (RSA) inertia is the temporary dependency of RSA levels between consecutive epochs, which captures the epoch-to-epoch stickiness of RSA reactivity. Previous studies examining the developmental function of between-task RSA reactivity have yielded mixed findings and have often overlooked RSA reactivity within the task. The present study examined whether RSA inertia during a stress task was associated with subsequent changes in child psychopathology symptoms.

The subcortical maternal complex modulates the cell cycle during early mammalian embryogenesis via 14-3-3.

The subcortical maternal complex (SCMC) is essential for safeguarding female fertility in mammals. Assembled in oocytes, the SCMC maintains the cleavage of early embryos, but the underlying mechanism remains unclear. Here, we report that 14-3-3, a multifunctional protein, is a component of the SCMC.

Parent emotional support alters the association between parent-child interbrain synchrony and interaction quality.

Using functional near-infrared spectroscopy (fNIRS) hyperscanning methodology, this study investigated whether parent emotional support moderated the relation between parent-child interbrain synchrony and interaction quality (via behavioral observation and child-report), controlling for individual emotional distress. Eighty-eight parent-child dyads (96.6% Han ethnicity), including a school-age child between the ages of 6 and 11 (M = 8.

Linking Parent-Adolescent Congruence in Perceived Parental Emotional Support to Adolescent Developmental Outcomes: The More, the Better?

Parents and their children can have congruent or incongruent perceptions of parenting, which has been shown to have downstream effects on certain adolescent outcomes. However, little is known about whether such effect holds for various domains of developmental outcomes or across adolescent boys and girls. Investigating 2268 parent-girl (M = 15.

Gender Difference in the Onset of Adolescent Depressive Symptoms: A Cross-Lagged Panel Network Analysis.

Depressive symptoms are prevalent in adolescents, especially girls, underscoring the need for early detection and targeted interventions. Identifying initial symptoms and their temporal associations is vital for such interventions. This study used cross-lagged panel network (CLPN) analysis to examine the central depressive symptoms and their interconnections within a national cohort derived from the China Family Panel Study (CFPS).

Parental autonomy support and psychological control and children's biobehavioral functioning: Historical cohort differences in urban China.

This study examined parental autonomy support and psychological control and their relations with child biobehavioral functioning. Participants included 238 Chinese parent-child dyads (M  = 8.38 years, 42.

The survival prediction of advanced colorectal cancer received neoadjuvant therapy-a study of SEER database.

Purpose: The aim of study was to screen factors associated with the overall survival of colorectal cancer patients with lymph nodes metastasis who received neoadjuvant therapy and construct a nomogram model.

Methods: All enrolled subjects of the SEER database were randomly assigned to the training and testing group in a ratio of 3:2. The patients of Tangdu Hospital were seemed as validation group.