Downregulation of transcription factor promoted nucleopolyhedrovirus replication in .

The Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway plays a crucial role in the viral immune processes of organisms, with STAT being a key transcription factor downstream in this pathway. The gene of has two splicing forms, named and . This study compared the effects of the two splicing forms on nucleopolyhedrovirus (BmNPV) infection through cell-level interference and further explored whether participates in the immune response to BmNPV infection via transgenic intervention at the individual level.

Transcription factor STAT enhanced antimicrobial activities in Bombyx mori.

STAT, a transcription factor in the JAK/STAT signaling pathway, regulates immune response to pathogens. In the silkworm (Bombyx mori), STAT exists as two split-forms, STAT-S and STAT-L. However, the role of STAT in silkworm immunity remains unclear.

Cytokine receptor DOME controls wing disc development in Bombyx mori.

In multicellular organisms, the JAK/STAT signaling pathway is involved in cell proliferation, differentiation, apoptosis, and immune regulation. Through activation of the Stat92E transcription factor, JAK/STAT signaling induced proper wing development in Drosophila. Domeless (DOME) was the first identified invertebrate JAK/STAT receptor.