Publications by authors named "Zhulun Zhuang"
Article Synopsis
- Copper is crucial for human health, and abnormalities in serum copper levels may influence health outcomes, especially concerning cardiovascular disease (CVD) risk factors in youth.
- A study analyzed data from 1,427 children and adolescents in the NHANES survey (2011-2014), finding significant associations between serum copper levels and several CVD risk factors such as cholesterol, glycohemoglobin, and fasting insulin.
- The research indicated that higher serum copper levels correlate with increased total cholesterol levels, marking the first epidemiological evidence for such an association in young populations, though the specific mechanisms behind these effects require further research.
Article Synopsis
- MTHFR (methylenetetrahydrofolate reductase) is linked to hyperhomocysteinemia, which may increase the risk for congenital heart defects (CHD), but its specific association has been unclear.
- An updated meta-analysis combining data from 16 studies found a significant link between the MTHFR A1298C polymorphism and CHD, particularly in patients without Down Syndrome.
- The study concludes that the MTHFR 1298C allele may be a risk factor for CHD, highlighting the need for more research on related factors like homocysteine levels and folic acid supplementation.
Article Synopsis
- Human caliciviruses, especially norovirus genotype GII.4, are significant causes of viral diarrhea in children, as highlighted by a study in China.
- Among 295 children with acute diarrhea, 10.85% tested positive for HuCV, with most being HBGA secretors or partial secretors, while only a small percentage of asymptomatic children tested positive.
- The findings suggest that blood type O may be linked to a higher risk of GII.3 infection, but due to the small sample size, additional research is needed for confirmation.
The objective of present paper is to study the immunogenicity of combinations of multiple vector vaccines expressing HIV-1 structural genes from different subtypes. Mice were vaccinated with DNA (B'/C) and rMVA (B'/C) vaccines expressing B'/C recombinant subtype gag-pol and env genes, DNA (B') and rAd5 (B') vaccines expressing subtype B' gag gene with different combination schemes. HIV-1 Gag-specific cellular immune responses and P24- specific IgG levels were analyzed by IFN-γ enzyme-linked immunospot assay (ELISPOT) and enzyme-linked immunosorbent assay (ELISA) respectively.
View Article and Find Full Text PDF[Immunogenicity of plasmid DNA and adenoviral vectors encoding HIV-1 subtype B env gene].
Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi
December 2010
Objective: To construct DNA and recombinant adenovirus vector vaccines containing an env gene from the prevalent subtype B strain in China and try to use them for therapeutic and prophylactic vaccines.
Methods: The candidate plasmid DNA vaccine pVR-gp160 and recombinant adenovirus vaccine rAdV-gp160 were constructed separately. BALB/c mice were immunized with these two vaccines in different administration schemes.
Objective: To compare the effectiveness of anesthesia between Isoflurane-based intravenous and inhalant combined approach and low-dose-ketamine-based total intravenous approach for valvuloplasty in minipigs.
Methods: Twenty four minipigs were given 3-5 mg/kg ketamine intramuscularly and 15-20 mg/kg pentobarbital intravenously for anesthetic induction and intubation. They were then randomly divided into two groups, each with 12 minipigs.