[Indicators of lipid metabolism and their relation to disorders of microcirculation in diabetes mellitus].

The levels of cholesterol, triglycerides, lipoproteins (LP), lipid peroxidation products (LPP), and tissue antioxidants were determined in 49 patients with diabetes mellitus (DM), types I and II, at the stage of subcompensation. The study groups were composed of patients with stages II and III capillaroscopic changes with corresponding changes in the fundus of the eye in the form of common and proliferating stages of retinopathy. Patients with DM of both types revealed significant changes in lipid metabolism expressed in the accumulation of highly atherogenic LP, an increase in the content of cholesterol and LPP in VLDLP and LDLP against a background of a decrease in the activity of the antioxidant system.

[Methodology of a planned clinical dietetic experiment with a program for processing the results on the Elektronika BZ-34 microcomputer].

Methods of planned clinical experiments on dietotherapy, adapted for the study of food additives in the absence of an adequate placebo, were improved due to the modification of the mathematical analysis. The schedule of the experiment involves exclusion of nonuniformity, reduction of the number of necessary studies and high accuracy of the final results. For the statistical analysis of the data obtained in the experiment a program has been proposed for the microcomputer.

[Protective properties of microcrystalline cellulose in experimental diabetes mellitus in rats].

The experiments on 45 inbred male and female rats with alloxan diabetes have shown that microcrystalline cellulose at a dose of 3 g/day received per os beginning from day 15 to day 42 after alloxan administration stabilizes the animals' body mass, reduces the level of glycemia and glycosylated hemoglobin. A parallel reduction of triglyceride and total cholesterol levels and increase in plasma phospholipid content, compared to the control, are observed, as well as a considerable hypocoagulation shift in the blood aggregation system.

[Effect of hyperbaric oxygenation on free-radical processes and gastric acid production in patients with duodenal ulcer].

Ascorbate- and NADPH-dependent free radical oxidation, the state of the antioxidant system, hydrogen iron secretion rate (HISR) and acid production kinetic function (AFKF) were investigated in 38 patients with duodenal ulcer to study the effect of hyperbaric oxygenation on free radical processes and gastric acid production. Assessment of the results of the study indicated the activation of NADPH-dependent free radical lipid oxidation, HISR acceleration and AFKF enhancement during hyperbaric oxygenation in the treatment of duodenal ulcer which required adjuvant corrective therapy.

[Food fibers as modifiers of homeostasis in patients with diabetes mellitus].

The addition of 7 g of fodder grass food fibers to the ration of 61 patients with diabetes mellitus 3 times a day resulted in a decrease in fasting hyperglycemia, reduced hyperlipoproteinemic shifts and induced a fall in the hemocoagulation potential in 3 weeks.