Publications by authors named "Zhuling Chu"
Background: Radiotherapy (RT) for breast cancer (BC) may raise the risk of second primary cancers (SPCs), a relationship inadequately studied.
Methods: We analyzed 248268 female BC patients from 9 SEER registries, 1988-2018, identifying SPCs >5 years after initial treatment, comparing SPC risks between RT and non-RT cohorts using Fine-Gray and Poisson regressions.
Results: Of all participants, 55.
Article Synopsis
- Tumor-infiltrating immune cells (TIICs) are crucial in the tumor microenvironment, with various types like CD8+ T cells and NK cells promoting anti-tumor effects, while Tregs and MDSCs foster tumor growth.
- The balance between pro- and anti-tumor TIIC responses is linked to patient prognosis, prompting the development of therapies such as immune checkpoint blockade, adoptive cell therapies, CAR T cells, and monoclonal antibodies to enhance anti-tumor immunity.
- Recent methods like single-cell RNA sequencing have revealed that TIICs exhibit diverse characteristics across different tumors, leading to varied therapeutic effectiveness, emphasizing the need for tailored immunotherapy approaches.
Lability and bioaccessibility of anthropogenic toxic heavy metals in arid calcareous soils are critical to understand their ecological and health risks. This study examined toxic heavy metal speciation in the calcareous soil contaminated by nonferrous metal smelting. Results demonstrated that approximately 70 years' nonferrous metal smelting and mining in Baiyin led to significant contamination of nearby soil down to about 200 cm depth by cadmium (Cd), copper (Cu), lead (Pb), and zinc (Zn), with more serious contamination in the downwind areas of smelting or mining.
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