[Learning curves in acquisition of experience for new technologies].

Objective: Analysis of national and foreign trials investigating accumulation of experience in innovative technologies using the learning curves.

Material And Methods. S: Earching for Russian-language manuscripts was carried out within the references of the articles and in the ELIBRARY database.

Atomic Structural Models of Fibrin Oligomers.

The space-filling fibrin network is a major part of clots and thrombi formed in blood. Fibrin polymerization starts when fibrinogen, a plasma protein, is proteolytically converted to fibrin, which self-assembles to form double-stranded protofibrils. When reaching a critical length, these intermediate species aggregate laterally to transform into fibers arranged into branched fibrin network.

Structural Basis of Interfacial Flexibility in Fibrin Oligomers.

Fibrin is a filamentous network made in blood to stem bleeding; it forms when fibrinogen is converted into fibrin monomers that self-associate into oligomers and then to polymers. To gather structural insights into fibrin formation and properties, we combined high-resolution atomic force microscopy of fibrin(ogen) oligomers and molecular modeling of crystal structures of fibrin(ogen) and its fragments. We provided a structural basis for the intermolecular flexibility of single-stranded fibrin(ogen) oligomers and identified a hinge region at the D:D inter-monomer junction.

Cell effects of xenon in vitro under hypothermal conditions.

The effects of Xe on cell viability and redox balance in the culture of Wistar rat thymocytes were studied in vitro during 24-h storage under hypothermic conditions. The results indicate that after bubbling of cell suspensions (5 x 10(6) cell/ml, 4 ml medium), the weight of Xe in flasks was 15-43 mg, whereas in cell-free medium no weight increment due to gas accumulation in the system was detected. The content of Xe in cell suspension slightly decreased over 24-h culturing at ambient temperature (by 10% of initial level).

[The orthostatic resistance of the cerebral and peripheral circulations in patients with contusive brain lesions].

Orthostatic tests with printing recording of EEG, REG, RVG were used to examine the functional status of the truncal level of circulatory regulation in patients with brain confusions. Within the first 24 hours after brain injury there was a significant reduction in the pulse blood filling of cerebral vessels in the vascularization areas of carotid and vertebral arteries along with higher vascular tone; pulse blood filling of peripheral vessels in the lower extremities remained normal with a marked decrease in their vascular tone. Orthostatic tests showed the asymmetric enhancement of a dilating arterial response in the virtual absence of a constrictive response of lower extremity vessels.

[Intraosseous electrostimulation in the treatment of arthrosis deformans].

The authors propose the new therapeutical technique of intraosseous electrostimulation for arthrosis deformans. The technique consists in that electric current is applied just to the area of joint lesion. It is highly effective, halves the period of therapy, reduces the frequency of relapses.

[Experience in using glutamic acid electrophoresis in the early treatment of craniocerebral injuries].

Endonasal electrophoresis with alpha-glutamic acid was used in 76 patients with severe craniocerebral injury. The result was good in 24 (38%) and satisfactory in 40 (55%) patients. Thus, a positive result of treatment was obtained in 88% of cases, which was confirmed by electrophysiological and neuropsychological studies.

[Treatment of patients with injuries of the ligaments of the knee joint].

178 patients with various ligamental injuries were treated according to the technique elaborated at the Institute. To restore ligaments preserved tendon homografts from the long fibular tendon with a remained terminal bone fragment were employed. The techniques of Gay-Growth-Smith and Sitenko underlie the methods of tendinoplasty applied.