Effects of sperm DNA fragmentation on embryo morphokinetic parameters and laboratory outcomes in women of different ages during intracytoplasmic sperm treatment cycles.

Background: Whether SDF (sperm DNA fragmentation) influences embryo development and the clinical outcomes of assisted reproductive technology (ART) cycles remains controversial. Oocytes derived from women of different ages have varying abilities to repair SDF.

Objective: This study aimed to explore the correlation between SDF and the morphokinetic parameters of embryos during intracytoplasmic sperm injection (ICSI) treatment cycles with consideration of the different ages of female patients.

Terpenoids from the Roots of (L.) and Their Bioactivities.

An undescribed diterpene, stellerterpenoid A (), and two undescribed sesquiterpenoids, stellerterpenoids B and C (-), together with six known compounds, prostratin () stelleraguaianone B (), chamaejasnoid A (), auranticanol L (), wikstronone C (), and oleodaphnone (), were isolated from the roots of L. Their structures were elucidated by extensive spectroscopic data (1D, 2D NMR, IR, UV, and HR-ESI-MS). The absolute configuration of - was elucidated based on ECD calculation.

Is Lenke Rule About Selective Thoracic Fusion Applicable for Younger Adult Idiopathic Scoliosis Under 40 Years of Age: Comparison With Adolescent Patients.

Study Design: Retrospective study.

Objective: To evaluate the surgical outcomes of younger adult idiopathic scoliosis patients (YAdIS) with selective thoracic fusion by comparing them with adolescent idiopathic scoliosis (AIS).

Methods: Seventy-two idiopathic scoliosis patients (36 adults and 36 adolescents) treated by posterior-only all-pedicle screw technique were retrospective reviewed and matched by fusion levels.

Two new iridoid glycosides from .

Two new iridoid glycosides, named productasperulosidic acid butyl ester () and -6--3-hydroxy--methoxycinnamoyl scandoside methyl ester (), along with nine known ones (), were isolated from Willd. The structures of them were elucidated by extensive 1D, 2D NMR and HR-ESI-MS spectral data. Compounds showed no significant cytotoxic activity against HeLa cells.

[Ruifuping pectin protects against intestinal mucosal injury in the rat exertional heat stroke model].

Objective: To evaluate the intestinal function in rats with exertional heat stroke (EHS) and explore the protective role of Ruifuping pectin (RFP) against heat related intestinal mucosal injury.

Methods: One hundred and twenty healthy special pathogen free (SPF) male Sprague-Dawley (SD) rats were randomly divided into normothermic control group, EHS model group, hyperthermic plus drinking water group (HO+EHS group) and hyperthermic plus pectin group (RFP+EHS group) with 30 rats in each group. The rats in the HO+EHS group and RFP+EHS group were given water 20 mL/kg or RFP 20 mL/kg orally for 5 days during adaptive training period.

Melatonin provides protection against heat stroke-induced myocardial injury in male rats.

Objectives: This study aimed to investigate the cardioprotective effects of melatonin on heat stroke (HS) induced acute myocardial infarction in rats and to explore the underlying mechanisms.

Methods: Myocardial injury was induced by subjecting the anaesthetized rats to a high ambient temperature of 43°C for 70 min. Such a high ambient temperature caused hyperthermia, hypotension and myocardial injury in rats.

Quercetin protects against heat stroke-induced myocardial injury in male rats: Antioxidative and antiinflammatory mechanisms.

Heat stroke is characterized by hyperthermia, systemic inflammation, and multiple organ failure including arterial hypotension. This definition can be fulfilled by a rat model of heat stroke used in the present study. Anesthetized animals were exposed to heat exposure (43 °C for 70 min) and then returned to room temperature (26 °C) for recovery.