Publications by authors named "Zhuhu Lin"
Krüppel-like factor 4 (KLF4) is an evolutionarily conserved zinc finger-containing transcription factor that regulates diverse cellular processes such as cell proliferation, apoptosis, and differentiation. Our previous study showed that KLF4 expression is upregulated in skeletal muscle ontogeny during embryonic development in pigs, suggesting its importance for skeletal muscle development and muscle function. We revealed here that KLF4 plays a critical role in skeletal muscle development and regeneration.
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- Skeletal muscle development is crucial for both medical applications and agricultural improvements, starting from somites where muscle precursor cells are formed.
- The study analyzed gene expression and chromatin accessibility in pig embryos to map out the development of skeletal muscle, identifying specific cells and their differentiation pathways.
- Key findings highlight new genes associated with muscle growth and potential regulators like EGR1 and RHOB, which may have implications for understanding muscle diseases in humans.