A Structurally Simple Polymer Donor Enables High-Efficiency Organic Solar Cells with Minimal Energy Losses.

Energy loss (Eloss) between optical energy gap (Eg) and open-circuit voltage (eVoc) sets efficiency upper limits for organic solar cells (OSCs). Nevertheless, further breaking the limit of Eloss in OSCs is challenging, especially via structurally simple materials in binary OSCs. Herein, a structurally simple non-halogenated polymer donor, namely PBDCT, is developed for realizing high-efficiency OSCs with record-breaking Eloss.

Adrenomedullin Inhibits the Efficacy of Combined Immunotherapy and Targeted Therapy in Biliary Tract Cancer by Disrupting Endothelial Cell Functions.

The global incidence of biliary tract cancer (BTC) is on the rise, presenting a substantial healthcare challenge. The integration of immune checkpoint inhibitors (ICIs) with molecularly targeted therapies is emerging as a strategy to enhance immune responses. However, the efficacy and underlying mechanisms of these treatments in BTC are still largely unexplored.

Biomimetic Localized Gel Electrolyte for Practical Zinc Anode.

Incompatible electrode/electrolyte interface often leads to dendrite growth, parasitic reactions and corrosion, posing significant challenges to the application of Zn anodes. Herein, we introduce a biomimetic antifreeze protein localized gel electrolyte (ALGE) with multifunctional capabilities to address these issues by combining electrolyte modification with interface optimization. ALGE modifies the Zn2+ solvation structure and the hydrogen-bond network adjacent to zinc anode, effectively suppressing hydrogen evolution.

A review in analytical progress for house dust mite allergens.

House dust mite (HDM) allergens are one of the most important causes of allergenic diseases in the indoor environment. The World Health Organization (WHO) has defined risk thresholds for Group I HDM allergens as a concentration of 2 and 10 μg/mL in dust for producing asthma risk and polar asthma attacks, respectively. Continuing exposure to high concentrations of HDM allergens greatly increases the risk of developing allergic diseases.

StZIP2 promotes root growth by improving the transport efficiency of zinc in potato(Solanum tuberosum L.).

Zinc is an essential trace element for plant growth and development. Zinc transporters play an important role in regulating zinc homeostasis in plants. In this study, the potato cultivar 'Atlantic' was used as experimental material to analyze the expression characteristics of the StZIP2 gene in different potato tissues under zinc deficiency stress.

Online monitoring and stable isotope tracing of cancer associated volatiles in murine model captures tumor associated markers in vivo.

Background: The imperative need for early cancer detection, which is crucial for improved survival rates in many severe cancers such as lung cancer, remains challenging due to the lack of reliable early-diagnosis technologies and robust biomarkers. To address this gap, innovative screening platforms are essential to unveil the chemical signatures of lung cancer and its treatments. It is established that the oxidative tumor environment induces alterations in host metabolic processes and influences endogenous volatile synthesis.

Mass spectrometric monitoring of redox transformation and arylation of tryptophan.

Tryptophan (Trp) is an essential amino acid obtained from human diet. It is involved not only in de novo biosynthesis of proteins but also in complex metabolic pathways. Redox transformation of tryptophan is under-explored in comparison with kynurenine, serotonin and indole pyruvate pathways.

Ratio fluorescence and smartphone-assisted colorimetry dual-mode detection of creatinine based on F, B, N-doped of red fluorescent carbon dots.

Background: Creatinine is a small molecule disease biomarker that reflects kidney function, accurate and effective detection of creatinine will play an important role in the prevention and treatment of diseases. Currently, commonly used creatinine detection methods are limited by expensive instruments, complex sample preparation, many interference factors from biological samples, and environmental factors that can affect the accuracy of the measurement. Therefore, developing a fast, simple, inexpensive, sensitive analysis method that can eliminate background interference and provide multi-detection modes has strong attraction and value.

A new removable connecting device for MARPE expander with non-common path of insertion.

Objectives: Maxillary transverse deficiency is a common malocclusion frequently observed in orthodontic clinics. Miniscrew-assisted rapid palatal expansion (MARPE) not only produces greater skeletal expansion but also offers advantages such as simple miniscrew implantation without flap elevation, enhanced patient comfort, and an expanded age range and indications for palatal expansion. However, the fixed connection between the expander and the miniscrews makes the expander difficult to remove, significantly hindering its clinical application.

Complement C5/C5a in the diagnosis and treatment of Graves ophthalmopathy: A Mendelian randomized study.

Objectives: Graves' ophthalmopathy is a complex organ-specific autoimmune disease with an unclear pathogenesis. Complement component 5/5a (C5/C5a), a key element of the component system, may play a significant role in the disease's pathological process. This study aims to investigate the causal relationship between C5/C5a and Graves' ophthalmopathy using Mendelian randomization (MR) to provide new theoretical insights for its diagnosis and treatment.

Agreement analysis of subjective and objective sleep quality in adolescents with mood disorders.

Objectives: Accurate assessment of sleep quality is crucial for understanding sleep problems and their impact on health. This study analyzed the agreement between subjective sleep assessments and objective sleep monitoring in adolescents with mood disorders, aiming to provide a reliable methodological foundation for related research.

Methods: Adolescents with mood disorders were recruited from psychiatric outpatient clinics of three domestic hospitals.

5HT1R agonist alleviates presurgical prolonged sleep deprivationinduced postsurgical pain in adolescent mice.

Objectives: Sleep deprivation (SD) is a risk factor for the development of chronic pain in adolescents, significantly affecting pain management and prognosis; however, the mechanisms by which SD influences postoperative pain outcomes remain unclear. This study aims to investigate the molecular mechanism through which the spinal 5-hydroxytryptamine 1 receptor (5-HT1R) regulates the excitation/inhibition (E/I) balance in the dorsal horn to modulate postoperative chronic pain induced by SD in adolescent mice.

Methods: A pain model combining 4.

Wearable device-measured physical activity and incident cardiovascular disease in cancer survivors.

Objective: To explore the association of wearable device-measured moderate-to-vigorous intensity physical activity (MVPA) with cardiovascular disease (CVD) risk in long-term cancer survivors.

Methods: This retrospective analysis involved a prospective cohort of 6109 cancer survivors without CVD from the UK Biobank accelerometry subsample. The MVPA volume is categorised into four groups based on guideline recommendations (0-75 min/week, 75-150 min/week, 150-300 min/week, ≥300 min/week).

p38γ modulates ferroptosis in brain injury caused by ethanol and cerebral ischemia/reperfusion by regulating the p53/SLC7A11 signaling pathway.

Ischemic stroke, a neurological condition with a complicated etiology that is accompanied by severe inflammation and oxidative stress, and ethanol (EtOH) may aggravate ischemia/reperfusion (I/R)-induced brain damage. However, the effect of prolonged alcohol intake on acute brain injury remains ambiguous. As part of the mitogen-activated protein kinase (MAPK) family, p38γ is involved in ferroptosis and inflammation in various diseases.

Identification and functional regulation of two alternative splicing isoforms of the Uhrf2 gene in Miichthys miiuy.

Alternative splicing can produce a variety of splicing isoforms to increase protein diversity, participate in the regulation of gene expression and the occurrence and development of diseases, and thus play an important role in innate immunity. Ubiquitin like with PHD and ring finger domains 2 (Uhrf2) protein is associated with cell proliferation, inflammation, tumors and cancer, and is currently the focus of medical immunology research, but there is little research on alternative splicing of the Uhrf2 gene. In this study, we identified two different splice isoforms of Uhrf2 in Miichthys miiuy through Sanger sequencing, dual-luciferase reporter gene assay, qRT-PCR, subcellular localization experiments, and named them Uhrf2-α and Uhrf2-β.

Alkaline-thermal synergistic activation of persulfate for sawdust hour-level humification to prepare fulvic-like-acid fertilizer.

Sawdust is a by-product of wood processing and it was rapidly humified with KSO under alkaline-thermal synergistic activation to produce a fulvic-like-acid (FLA) organic fertilizer (SFOF) in this study. The optimum conditions were KSO: KOH mass ratio of 1:2 and 150℃, meanwhile FLA yield could reach 180.3 mg/g in 2 h.

Perspectives on adhesion and irreversible fouling to delineate mitigation effects of autoinducer-2 mediated quorum quenching on biofouling.

This study systematically investigated the effect of interfering with autoinducer-2 (AI-2) signaling system on controlling initial fouling attachment and irreversible components. Exposure of bacteria to the inhibitor significantly reduced the expression of the luxS gene, which resulted in a 37.3% reduction of AI-2 signaling molecule synthesis.

Protective effects of anthocyanins on the nervous system injury caused by fluoride-induced endoplasmic reticulum stress in rats.

Long-term fluoride exposure can produce neurotoxicity. Anthocyanins, as antioxidants, have a certain protective effect in nerve damage. This study aimed to investigate the protective role of anthocyanins in fluoride-induced neurological damage due to endoplasmic reticulum stress (ERS).

A Mannosylated peptidyl lipid CManDA doped into cytidinyl/cationic lipids efficiently delivers siG12Ss to lung cancer in vivo.

Gene therapy has attracted widespread attention in recent years, and one of the important delivery systems is the LNP. However, many LNPs have potential toxicity and accumulate in the liver. Here, we designed and synthesized a Gemini-type mannosylated peptidyl lipid called CManDA(M), which, in combination with the cytidinyl lipid DNCA(D) and the peptidyl lipid CLD(C) (D/50C/50 M), could transfect siRNA (siG12S) into A549 cells to target and silence the KRAS gene.

Elucidating the co-metabolism mechanism of 4-chlorophenol and 4-chloroaniline degradation by Rhodococcus through genomics and transcriptomics.

Co-metabolism is an effective strategy for the removal of refractory pollutants during biodegradation. This study reports that Rhodococcus DCB-5 can utilize 4-chlorophenol as a growth substrate to initiate the co-metabolic degradation of 4-chloroaniline. Comprehensive analyses of the genome, transcriptome, enzymes, and intermediate products identified key genes and a putative co-metabolic degradation pathway involved in the degradation process by Rhodococcus.

PTPσ-mediated PI3P regulation modulates neurodegeneration in C9ORF72-ALS/FTD.

The most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) is the repeat expansion in C9ORF72. Dipeptide repeat (DPR) proteins translated from both sense and antisense repeats, especially arginine-rich DPRs (R-DPRs), contribute to neurodegeneration. Through CRISPR interference (CRISPRi) screening in human-derived neurons, we identified receptor-type tyrosine-protein phosphatase S (PTPσ) as a strong modifier of poly-GR-mediated toxicity.

Oxidative stress markers predict treatment outcomes in patients with generalized anxiety disorder treated with selective serotonin reuptake inhibitors.

Introduction: The etiology of generalized anxiety disorder (GAD) has not been fully understood, and oxidative stress may potentially contribute to its pathogenesis. However, there is no published evidence concerning the possible influence of oxidative stress on antidepressant treatment outcomes. This study investigated the ability of oxidative stress markers to predict treatment outcomes in GAD patients treated with selective serotonin reuptake inhibitors (SSRIs).

Psychological resilience to trauma and longitudinal sleep outcomes among current and former nurses.

Objective: A life-disrupting stressor (e.g. pandemic) may cause or exacerbate poor sleep health; resilience may offset impacts.

The impact of emotional freedom techniques on anxiety, depression, and anticipatory grief in people with cancer: A meta-analysis and systematic review.

Objective: Emotional Freedom Techniques (EFT) is a self-healing method that combines Eastern meridian acupuncture and Western psychology. This meta-analysis evaluates the efficacy of EFT in reducing anxiety, depression, and anticipatory grief symptoms in people with cancer.

Methods: A comprehensive search was conducted across nine databases, including Cochrane Library, Embase, PubMed, Web of Science, Google Scholar, CBM, WeiPu, CNKI, and WanFang, up to May 2024.