From the archives of MD Anderson Cancer Center: Composite mantle cell lymphoma and lymphoplasmacytic lymphoma involving bone marrow at presentation.

Composite lymphoma, defined as two or more distinct well-defined entities involving the same anatomic site, is rare. Here we report a 79-year-old woman with composite mantle cell lymphoma (MCL) and lymphoplasmacytic lymphoma (LPL) involving bone marrow at the time of initial diagnosis. The patient presented with splenomegaly and lymphadenopathy and laboratory studies showed an elevated serum IgM level and IgM kappa paraprotein.

Acute myeloid leukemia with concurrent and mutations.

mutation, as a founding genetic event, cooperates with other gene mutations, such as and , to promote the development of acute myeloid leukemia. mutation, however, has been reported to be mutually exclusive with mutation in acute myeloid leukemia cases. In this study, we analyzed mutation panel testing data from a relatively large cohort of rare AML cases with both and mutations.

Plasma cell myeloma with RAS/BRAF mutations is frequently associated with a complex karyotype, advanced stage disease, and poorer prognosis.

Background: Mutations in the RAS-MAPK pathway, such as KRAS, NRAS, and BRAF, are known as high-risk factors associated with poor prognosis in patients with various cancers, but studies in myeloma have yielded mixed results.

Methods: We describe the clinicopathologic, cytogenetic, molecular features, and outcomes of 68 patients with RAS/BRAF-mutated myeloma, and compare with 79 patients without any mutations.

Results: We show that KRAS, NRAS, and BRAF were mutated in 16%, 11%, and 5% of cases, respectively.

Isolating the Oxygen Adsorption Defects on Sputtered Tin Oxide for Efficient Perovskite Solar Cells.

Tin oxide (SnO) is the most commonly used electron transport material for perovskite solar cells (PSCs). Various techniques have been applied to deposit tin dioxide, including spin-coating, chemical bath deposition, and magnetron sputtering. Among them, magnetron sputtering is one of the most mature industrial deposition techniques.

Concurrent Mutations in and in Myeloid Neoplasms.

It has been reported that gene mutations in and are mutually exclusive. However, this observation has never been rigorously assessed. We report the clinicopathologic and molecular genetic features of 21 cases of myeloid neoplasms with double mutations in and , including 9 (43%) with myelodysplastic syndrome, 5 (24%) with acute myeloid leukemia, 4 (19%) with myeloproliferative neoplasms, and 3 (14%) with myelodysplastic/myeloproliferative neoplasms.

The Impact of Mutation of Myelodysplasia-Related Genes in De Novo Acute Myeloid Leukemia Carrying Mutation.

Background: The impact of gene mutations typically associated with myelodysplastic syndrome (MDS) in acute myeloid leukemia (AML) with NPM1 mutation is unclear. Methods: Using a cohort of 107 patients with NPM1-mutated AML treated with risk-adapted therapy, we compared survival outcomes of patients without MDS-related gene mutations (group A) with those carrying concurrent FLT3-ITD (group B) or with MDS-related gene mutations (group C). Minimal measurable disease (MMD) status assessed by multiparameter flow cytometry (MFC), polymerase chain reaction (PCR), and/or next-generation sequencing (NGS) were reviewed.

ETNK1 mutation occurs in a wide spectrum of myeloid neoplasms and is not specific for atypical chronic myeloid leukemia.

Background: ETNK1 mutation has been suggested as a useful tool to support the diagnosis of atypical chronic myeloid leukemia. ETNK1 mutations, however, occur in other myeloid neoplasms.

Methods: The authors assessed the clinicopathologic and molecular genetic features of 80 ETNK1-mutated myeloid neoplasms.

Integrated clinical genotype-phenotype characteristics of early T-cell precursor acute lymphoblastic leukemia.

Background: Early T-cell precursor acute lymphoblastic leukemia (ETP-ALL) is a distinct subtype of T-ALL with a unique immunophenotype and high treatment failure rate. The molecular genetic abnormalities and their prognostic impact in ETP-ALL patients are poorly understood.

Methods: The authors performed systematic analyses of the clinicopathologic features with an emphasis on molecular genetic aspects of 32 patients with ETP-ALL.

Flexible and Conductive Polymer Threads for Efficient Fiber-Shaped Supercapacitors Vapor Copolymerization.

Flexible fiber electrodes are critical for high-performance fiber and wearable electronics. In this work, we presented a highly conductive all-polymer fiber electrode by vapor copolymerization of 2,5-dibromo-3,4-vinyldioxythiophene (DBEDOT) and 2,5-diiodo-3,4-vinyldioxythiophene (DIEDOT) monomers on commonly used polyester threads (PETs) at a temperature as low as 80 °C. The poly(3,4-ethylenedioxythiophene) (PEDOT)-coated PET threads maintain excellent flexibility and show conductivity of 7.

Doping Mechanism of Perovskite Films with PbCl Prepared by Magnetron Sputtering for Enhanced Efficiency of Solar Cells.

The last decade has witnessed a rapid growth of perovskite solar cells extended from mesoporous to planar architecture as well as from solution processing to solvent-free fabrication. The preparation of perovskite films by solvent-free method still presents significant challenges, such as the difficulty of film preparation by multiple evaporation sources in vapor deposition and the immaturity of the sputtered method. Here, we present a planar perovskite solar cell fabricated by solvent-free magnetron sputtering without the assistance of the mesoporous TiO layer, and lead chloride (PbCl) was mechanically milled into the target of methylammonium lead halides (MAPbI) to improve the quality of perovskite film by regulating the crystallization process with the Cl element.

Acute promyelocytic leukemia: Immunophenotype and differential diagnosis by flow cytometry.

Background: Prompt diagnosis of acute promyelocytic leukemia (APL) is critical for patient care. In this study, we aimed to characterize the immunophenotype of APL and explore immunophenotypic difference between APL and its mimics using flow cytometric analysis.

Methods: Eighty-five cases were collected, including 47 APL, 26 NPM1-mutated acute myeloid leukemia (AML) and 12 KMT2A-rearranged AML with an APL-like immunophenotype.

Landscape of NOTCH1 mutations and co-occurring biomarker alterations in chronic lymphocytic leukemia.

NOTCH1 is one of the most frequently mutated genes in chronic lymphocytic leukemia and has emerged as a marker of poor prognosis. In addition to coding NOTCH1 mutations involving exon 34, non-coding NOTCH1 mutations involving the 3' UTR have been described in a limited number of chronic lymphocytic leukemia (CLL) patients and were associated with adverse outcomes. In this study, 1574 CLL patients were assessed using targeted sequencing with a 29 gene panel and the results were correlated with prognostic characteristics.

Genome-wide identification of genes in and their expression under different nitrogen treatments.

Unlabelled: Fructokinase (FRK) is the main fructose phosphorylase and plays an important role in catalyzing the irreversible reaction of free fructose phosphorylation. In order to study the regulatory effect of different forms and concentrations of nitrogen on genes in , seven genes encoding the hypothetical FRK proteins were identified in genome by bioinformatics method. Phylogenetic analysis revealed that family genes can be divided into two subgroups: SI () and SII ().

Organic-Inorganic Perovskite Films and Efficient Planar Heterojunction Solar Cells by Magnetron Sputtering.

Organic-inorganic halide perovskites have been widely used in photovoltaic technologies. Despite tremendous progress in their efficiency and stability, perovskite solar cells (PSCs) are still facing the challenges of upscaling and stability for practical applications. As a mature film preparation technology, magnetron sputtering has been widely used to prepare metals, metallic oxides, and some semiconductor films, which has great application potential in the fabrication of PSCs.

Genome Identification and Expression Profiles in Response to Nitrogen Treatment Analysis of the Class I CCoAOMT Gene Family in Populus.

Lignin is essential for the characteristics and quality of timber. Nitrogen has significant effects on lignin contents in plants. Nitrogen has been found to affect wood quality in plantations and lignin content in plants.

Fate of mercury and methylmercury in full-scale sludge anaerobic digestion combined with thermal hydrolysis.

Methylmercury (MeHg) is one of the highly toxic and bio-accumulated forms of mercury. Its presence in wastewater treatment processes has been evidenced in recent studies. Considering its enrichment in sewage sludge and the ecological risk associated with its land application, this study investigated the fate of mercury and MeHg in full-scale anaerobic digestion combined with Cambi thermal hydrolysis based on one-year sampling.

Mechanochemical synthesis of pure phase mixed-cation/anion (FAPbI) (MAPbBr) hybrid perovskite materials: compositional engineering and photovoltaic performance.

Organic-inorganic hybrid perovskites have emerged as promising light harvesting materials for many optoelectronic devices. Here, we present a facile mechanochemical synthesis (MCS) route for the preparation of a series of pure phase mixed-cation/anion (FAPbI) (MAPbBr) (0 ≤ ≤ 1) hybrid perovskite materials for high-efficiency thin-film perovskite solar cells (PSCs). The use of (α-FAPbI)(MAPbBr) perovskite prepared by MCS for the thin-film PSCs achieves a maximum PCE of 15.

Tertiary lymphoid structures with overlapping histopathologic features of cutaneous marginal zone lymphoma during neoadjuvant cemiplimab therapy are associated with antitumor response.

The development of immune checkpoint inhibitor (ICI) therapy with anti-CTLA-4 and anti-PD-1/L1 monoclonal antibodies has led to a paradigm shift in cancer therapy. ICI neoadjuvant therapy followed by surgery has become the standard of care for several advanced-stage cancers. The pathology associated with ICI therapy is vast and includes neoadjuvant-associated tissue reactions and activation of tertiary lymphoid structures (TLSs) at the site of the tumor bed and off-target immune-related adverse events.

[Effect on Ammonia Inhibition Mitigation in the Anaerobic Digestion Process with Zero-Valent Iron].

Ammonia inhibition is an important factor impacting methane production efficiency during the anaerobic digestion of high-solid organic wastes. This study investigated the effect of micro-sized zero-valent iron (m-ZVI) on the anaerobic digestion of excess sewage sludge and thermal hydrolyzed sludge using batch mode experiments. The effect of m-ZVI on ammonia inhibition mitigation was also studied.

Analysis of the energy source at the early stage of poplar seed germination: verification of Perl's pathway.

Adenosine triphosphate (ATP) is produced at the early stage of seed germination and provides the energy for metabolism. The source of ATP in seeds may be Perl's pathway, but this has not yet been confirmed. In this study, using germinating seeds of poplar as the experimental materials, the transcript levels of genes related to Perl's pathway were determined by real-time PCR.

[Effect of Sulfate on the Migration and Transformation of Methylmercury in Advanced Anaerobic Digestion of Sludge].

To study the migration and transformation of methylmercury during advanced anaerobic digestion of sludge and the role of sulfate, this study investigated the migration and transformation of methylmercury during different stages of sludge anaerobic digestion (AD) with thermal hydrolysis pretreatment and under different dosages of sulfate addition. The results showed that mercury methylation occurred in the initial stage of AD (Day 1-3), the ratio of methylmercury to total mercury increased from 0.024% (range of 0.