Synthesis and Physical Properties of a Phenanthrene-Based [6,6] Hollow Bilayer Cylindrical Nanoring.

Herein, we report the synthesis and properties of a [6,6] hollow bilayer cylindrical nanoring () from a planar macrocycle via a Diels-Alder and Yamamoto coupling reaction. The fluorescence quantum yield of was determined to be = 52%, which is four times higher than its precursor. In addition, its hollow nanoring configuration was also simulated by theoretical studies, and the tension energy was estimated to be 47.

Distinct bacterial community of a solid-state fermented Chinese traditional food huase sufu revealed by high-throughput sequencing.

Unlabelled: Sufu is a common solid-state traditional fermented food made from soybean. Huase sufu is a typical type found in several provinces of China, especially in Hubei. However, little is known about the bacterial community.

miR-539 activates the SAPK/JNK signaling pathway to promote ferropotosis in colorectal cancer by directly targeting TIPE.

Colorectal cancer (CRC) is a common tumor that harms human health with a high recurrence rate. It has been reported that the expression of microRNA-539 (miR-539) is low in several types of cancer, including CRC. Tumor necrosis factor (TNF)-α-induced protein 8 (TNFAIP8/TIPE) is highly expressed in CRC and promotes the proliferation, migration and angiogenesis of CRC.

The proliferation rule of Microcystis aeruginosa under different initial pH conditions and its influence on the pH value of the environment.

This study investigated the characteristics of the proliferation process of Microcystis aeruginosa and its changes to environmental pH values under different initial pH values and different initial inoculation densities. The results showed that although the initial pH value or the initial inoculation density was different, the pH values of the culture systems fluctuated up and down throughout the proliferation of M. aeruginosa, both on a daily and hourly time scale, and then tended to stabilize around the same value of 10.

Long-time measurements of line-integrated plasma electron density using a two-color homodyne optical fiber interferometer.

A two-color homodyne Mach-Zehnder (M-Z) optical fiber interferometer with wavelengths of 1.55 and 1.31 µm was developed for long-time measurement of line-integrated plasma electron density.

[Microbial Community Structure of Soil Methanogens and Methanotrophs During Degradation and Restoration of Reed Wetlands in the Songnen Plain].

Wetlands are an important global source and sink of methane. However, human activities and climatic conditions are causing serious degradation of wetlands in China. In response to this, the relevant departments have progressively carried out wetland restoration projects over the past few years.

Dual effect of the coordination field and sulphuric acid on the properties of a single-atom catalyst in the electrosynthesis of HO.

Electrocatalytic synthesis of hydrogen peroxide (HO) the two-electron oxygen reduction reaction (2e ORR) is the ideal solution for on-site HO production. Herein, we propose a new strategy for creating new 2e ORR catalysts by introducing electron-deficient B atoms and electron-rich N atoms to regulate the coordination field of metal ions on a graphene substrate. Through the first-principles density functional theory (DFT) calculations, NiNB-h was screened out as it had a low overpotential (0.

Metabolic Profiling of Carbonyl Compounds for Unveiling Protective Mechanisms of against Diabetic Nephropathy by UPLC-Q-Orbitrap HRMS/MS Analysis.

Carbonyl compounds play a critical role in the pathogenesis of diabetic nephropathy (DN). (PL), also known as "Kudzu", is a widely consumed functional food or nutraceutical and has shown promise in the prevention of diabetes and complications such as DN. To explore the beneficial effects and the underlying mechanisms of PL against DN, a new strategy for in-depth metabolic profiling of carbonyl compounds in DN mice plasma by chemical derivatization combined with UPLC-Q-Orbitrap high-resolution mass spectrometry (HRMS)/MS analysis was developed for the first time.

Synthesis and properties of a nanographene-embedded conjugated macrocyclic nanoring the Scholl reaction.

Direct π-extension by the Scholl reaction for solution-based growth of armchair edges in curved macrocyclic hydrocarbon nanostructures is a great challenge. To date, several attempts at direct π-extension of small highly strained macrocycles have failed. Herein, we report a fixed two-bond approach for direct functionalization of small strained macrocyclic nanorings.

Toxicological Effects of Artificial Fine Particulate Matter in Rats through Induction of Oxidative Stress and Inflammation.

Airborne fine particulate matter with an aerodynamic diameter equal to or smaller than 2.5 μm (abbreviated as PM) increases the risk of nasal lesions, but the underlying molecular mechanism has not been fully elucidated. In the atmosphere, the composition of PM collected varies in physical and chemical properties, which affects its damage to human health.

Cost-effectiveness of risk-stratified endoscopic screening for esophageal cancer in high-risk areas of China: a modeling study.

Background And Aims: Risk-stratified endoscopic screening (RSES) has been suggested to improve screening efficiency. We aimed to assess the cost-effectiveness of RSES and identify the optimal risk-score thresholds for once in a lifetime esophageal cancer (EC) screening in high-risk areas of China.

Methods: From a healthcare system perspective, a Markov model was constructed to compare the cost-effectiveness of 13 RSES strategies (under different score thresholds for EC risk), universal endoscopic screening strategy, and no screening.

The lag effect of exposure to PM on esophageal cancer in urban-rural areas across China.

Exposure to PM pollution is a significant health concern and increases risks for cancers in China. However, the studies regarding the effect of PM and esophageal cancer incidence (ECI) among urban-rural areas are limited. In this study, we examined the sex- and area-specific association between exposure to PM and ECI, as well as explored the corresponding lag effects on ECI using a geographical weighted Poisson regression.

Estimated Cost-effectiveness of Endoscopic Screening for Upper Gastrointestinal Tract Cancer in High-Risk Areas in China.

Importance: Upper gastrointestinal tract cancer, including esophageal and gastric cancers, in China accounts for 50% of the global burden. Endoscopic screening may be associated with a decreased incidence of and mortality from upper gastrointestinal tract cancer.

Objective: To evaluate the cost-effectiveness of endoscopic screening for esophageal and gastric cancers among people aged 40 to 69 years in areas of China where the risk of these cancers is high.

Repeat laboratory testing of SARS-CoV-2 is necessary to diagnose COVID-19.

The pandemic of corona virus disease 2019 (COVID-19) caused by SARS-CoV-2 is ravaging the world. Diagnosis and isolation of persons who are infected with SARS-CoV-2 is very important medical emergency to contain the epidemic of COVID-19. To date, the diagnosis of COVID-19 is mainly depending on positive quantitative reverse transcriptase polymerase chain reaction (qRT-PCR) results for SARS-CoV-2.

USP12 downregulation orchestrates a protumourigenic microenvironment and enhances lung tumour resistance to PD-1 blockade.

Oncogenic activation of KRAS and its surrogates is essential for tumour cell proliferation and survival, as well as for the development of protumourigenic microenvironments. Here, we show that the deubiquitinase USP12 is commonly downregulated in the Kras-driven mouse lung tumour and human non-small cell lung cancer owing to the activation of AKT-mTOR signalling. Downregulation of USP12 promotes lung tumour growth and fosters an immunosuppressive microenvironment with increased macrophage recruitment, hypervascularization, and reduced T cell activation.

Collaboratively boosting charge transfer and CO chemisorption of SnO to selectively reduce CO to HCOOH.

In this study, we have facilely developed a SnO-based electrocatalyst (SnO-V@N-C), which can combine together the favorable structure features of oxygen vacancies, porosity, and full-coating with N-doped carbon layers (N-C). Our experimental and theoretical calculation results indicated that with the facile engineering of oxygen vacancies and the full-coating of the N-doped carbon layer, the adsorption/activation of CO and charge transfer can be promoted in the CO reduction process, making SnO-V@N-C the electrocatalyst with improved activity and selectivity (FE = 84%) toward the reduction of CO to HCOOH.

Enantioselective Recognition and Separation of Symmetric Substances via Chiral Metal-Organic Frameworks.

A promising route toward the enantioselective recognition and separation of racemic molecules is the design of chiral metal-organic frameworks (CMOFs) with high enantioselectivity and stability. Herein, we report porous CMOFs Δ- and Λ-RuEu-MOFs constructed from the -symmetry helical chiral Ru(phen)-derived tricarboxylate ligand and Eu units, which can be utilized as adsorbents for the enantioselective recognition and separation of 1,1'-bi-2-naphthol (BINOL) derivatives. Investigation of the circular dichroism enantiodifferentiation between the host and guest suggested that Δ- and Λ-RuEu-MOFs can be employed as chiral sensors to discriminate axial enantiomers due to their diastereomeric host-guest relationship.

Pancreatoduodenectomy within 2 weeks after endoscopic retrograde cholangio-pancreatography increases the risk of organ/space surgical site infections: a 5-year retrospective cohort study in a high-volume centre.

Background: Organ/space surgical site infections (OSSI) after pancreaticoduodenectomy (PD) are not rare events. The role of diagnosis and treatment for pancreatic and biliary diseases with an endoscopic retrograde cholangio-pancreatography (ERCP) procedure is currently controversial. However, the ERCP procedure might play a role in surgical outcomes after PD.

Efficiency and mechanism of reducing ammonia volatilization in alkaline farmland soil using Bacillus amyloliquefaciens biofertilizer.

Ammonia volatilization from the farmland caused by the application of synthetic nitrogen fertilizer is the most important source of anthropogenic ammonia emissions. Biofertilizer application has been considered as an alternative option for agriculture sustainability and soil improvement. In this study, field trials were carried out to investigate the efficiency of Bacillus amyloliquefaciens (BA) biofertilizer on alleviating ammonia volatilization in alkaline farmland soil and increasing crop yield and nitrogen utilization.

Epigenetic heterogeneity promotes acquired resistance to BET bromodomain inhibition in ovarian cancer.

BET bromodomain inhibitors (BETi) are promising therapeutic regimens for epithelial ovarian cancer (EOC). However, early-stage clinical trials indicate that drug tolerance may limit their anti-tumor efficacy. Here, we show that JQ1-refractory EOC cells acquire reversible resistance to BET inhibition and remain dependent on BRD4 function.

The cross-polarization scattering system for the magnetic fluctuation measurement in the Experimental Advanced Superconducting Tokamak.

The cross-polarization scattering (CPS) system for magnetic fluctuation measurements in the Experimental Advanced Superconducting Tokamak (EAST) has been designed and installed. Different from the Doppler reflectometer (DR) system, the CPS system detects the perpendicular polarization of the electromagnetic wave induced by magnetic fluctuations B̃. The CPS system in the EAST has been developed from the existing Doppler reflectometer system, and they are integrated together for simultaneous measurement of magnetic and density fluctuations.

Mendelian randomization analysis identified genes potentially pleiotropically associated with periodontitis.

Objective: To prioritize genes that were pleiotropically or potentially causally associated with periodontitis.

Methods: We applied the summary data-based Mendelian randomization (SMR) method integrating genome-wide association study (GWAS) for periodontitis and expression quantitative trait loci (eQTL) data to identify genes that were pleiotropically associated with periodontitis. We performed separate SMR analysis using CAGE eQTL data and GTEx eQTL data.

Seasonality of dimethylated sulfur compounds cycling in north China marginal seas.

Dimethylated sulfur compounds play an important role in global sulfur cycle. We investigated the seasonality of dimethylsulfoniopropionate (DMSP), dimethylsulfoxide (DMSO), dimethylsulfide (DMS) and associated processes in two north China marginal seas during 2014 and 2016. High concentrations of DMS, DMSP and DMSO occurred in summer/spring, while the lowest were observed in winter.

Virus-encoded microRNA-M7 restricts early cytolytic replication and pathogenesis of Marek's disease virus.

MicroRNAs (miRNAs) are a class of ∼22 nucleotides non-coding RNAs that are encoded by a wide range of hosts. Viruses, especially herpesviruses, encode a variety of miRNAs that involved in disease progression. Recently, a cluster of virus-encoded miRNAs, miR-M8-M10, have been shown to restrict early cytolytic replication and pathogenesis of Marek's disease virus (MDV), an oncogenic avian alphaherpesvirus that causes lymphoproliferative disease in chickens.