Mitochondrial expression and activity of P-glycoprotein under oxidative stress in outer blood-retinal barrier.

Aim: To investigate the role of oxidative stress in regulating the functional expression of P-glycoprotein (P-gp) in mitochondria of D407 cells.

Methods: D407 cells were exposed to different ranges of concentrations of HO. The mitochondrial location of P-gp in the cells subjected to oxidative stress was detected by confocal analysis.