Publications by authors named "Zhuan Peng"
Diabetic Kidney Disease (DKD), a major precursor to end-stage renal disease, involves mitochondrial dysfunction in proximal renal tubular cells (PTCs), contributing to its pathogenesis. Estrogen-related receptor α (ERRα) is essential for mitochondrial integrity in PTCs, yet its regulation in DKD is poorly understood. This study investigates ERRα expression and its regulatory mechanisms in DKD, assessing its therapeutic potential.
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- Hyperuricemic nephropathy (HN) is a disorder marked by problems in uric acid metabolism, leading to elevated uric acid levels and kidney damage, characterized by fibrosis.
- The drug dapagliflozin shows promise in lowering uric acid levels in chronic kidney disease (CKD) patients, but its specific benefits for hyperuricemic nephropathy are still being explored.
- The study reveals that dapagliflozin helps reduce kidney damage by activating a key receptor (ERRα) involved in uric acid processing and indicates its potential to treat fibrosis in both HN and other forms of CKD.
Background: Diabetic kidney disease (DKD) is a leading cause of end-stage renal disease (ESRD). The progression of DKD is often marked by heightened renal fibrosis due to hindered fatty acid oxidation within renal tubules. Baicalin (BA), a naturally derived compound, has exhibited the potential to mitigate the advancement of DKD.
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