Preventive effects of rutin on the development of experimental diabetic nephropathy in rats.

Aims: Diabetic nephropathy (DN) is an important microvascular complication and one of the main causes of end-stage renal disease. In this study, the preventive effect and mechanism of rutin on the development of DN in streptozotocin (STZ)-induced diabetic rats were investigated.

Main Methods: After an early DN model was induced by STZ, rats were orally administered rutin at 3 doses for 10 weeks.