Chronic HBV infection patients who do not conform to any of the usual immune states are regarded as 'grey zone' patients. We aimed to investigate the proportion of chronic HBV infection patients in the grey zone, and evaluate the clinical characteristics and liver pathological changes in grey zone patients. Clinical data of 1391 treatment-naive chronic HBV infection patients with liver biopsy were collected.
View Article and Find Full Text PDFBackground: Hepatocyte death, either apoptosis or necrosis, is closely associated with hepatic inflammation and fibrosis.
Aims: To investigate the potential values of hepatocytes death biomarker, M30 (apoptosis) and M65 (total death) in predicting histological lesions in chronic hepatitis B virus (HBV) infection.
Methods: Total 201 treatment-naïve patients were prospectively recruited.