Publications by authors named "Zhu-Hong Lu"
Ribonucleotide reductase catalyzes the rate limiting step of deoxyribonucleotide formation, a crucially important step in DNA synthesis and repair. The regulatory subunit M1 of ribonucleotide reductase (RRM1) is the necessary part of the RR function and controls substrate specificity and global on/off enzyme activity. Despite recent research progress, the role of RRM1 in lung cancer sensitivity to chemotherapeutics remains to be elucidated.
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- * The study used gene expression microarrays to analyze how 5-aza-2'-deoxycytidine affected gene expression and cell behavior in liver cancer cells, particularly focusing on gene upregulation and apoptosis.
- * Results indicated that while many genes crucial for tumor growth and regulation were activated, a significant number lacked the typical promoter features associated with methylation, suggesting complex mechanisms of gene regulation at play beyond just methylation inhibition.