Noise alters guinea pig's blood-labyrinth barrier ultrastructure and permeability along with a decrease of cochlear Claudin-5 and Occludin.

Background: Noise exposure (NE) is a severe modern health hazard that induces hearing impairment. However, the noise-induced ultrastructural changes of blood-labyrinth barrier (BLB) and the potential involvements of tight junction proteins (TJP) remain inconclusive. We investigated the effects of NE on not only the ultrastructure of cochlea and permeability of BLB but also the expression of TJP within the guinea pig cochlea.

[Molluscicidal effects of 3 molluscicides by spraying and poudrage methods in dry season].

Objective: To evaluate the effects of 3 molluscicides namely 5% niclosamide ethanolamine granules, 4% "Luowei" (Tea-seed distilled saponins, TDS) and 50% wettable powder of niclosamide ethanolamine salt (WPN) by spraying and poudrage methods in marshland and lake regions in dry season.

Methods: An environment with a high snail density was chosen as the experimental field, then the spraying and poudrage experiments were carried out in the field to assess the molluscicidal effects of 5% niclosamide ethanolamine granules, TDS and WPN delivered by spraying and poudrage methods with a concentration of 30, 6 and 2 g/m2, respectively, and the molluscicidal effects of the 3 drugs by the two methods were evaluated and compared in different time.

Results: After the delivery for 15 d, the adjusted snail death rates of the 5% niclosamide ethanolamine granules, TDS and WPN in the spraying experiment were 79.

[Molluscicidal effect of plastic film mulch covering method].

Objective: To evaluate the molluscicidal effect of the plastic film mulch covering method.

Methods: In the barren land with a lot of Oncomelania hupensis snails, 3 experimental groups were set up, in which respectively using 3 different methods: a simple plastic film mulch covering method, film assisted with ammonium bicarbonate, and film assisted with amine molluscicide. In the canals, two experimental groups were set up, in which respectively using 2 different methods: simple plastic film mulch covering method and film assisted with ammonium bicarbonate.

Expression and localization of atrial natriuretic peptide and its receptors in rat spiral ganglion neurons.

Spiral ganglion neurons (SGNs) are the primary auditory neurons in the inner ear, conveying auditory information between sensory hair cells and the central nervous system. Atrial natriuretic peptide (ANP), acting through specific receptors, is a regulatory peptide required for a variety of cardiac and neuronal functions. While the localization of ANP and its receptors (NPR-A and NPR-C) in the inner ear has been widely studied, there is only limited information regarding their localization in cochlear SGNs and their regulatory roles during primary auditory neurotransmission.

[Surveillance of schistosomiasis in Caohui Village, Yangxin County, 2005-2010].

The surveillance of schistosomiasis in a national schistosomiasis surveillance site, Caohui Village, Yangxin County, 2005 - 2010 showed that the infection rates of residents and livestock decreased from 4.56% and 28.33% to 1.