Cepharanthine, a regulator of keap1-Nrf2, inhibits gastric cancer growth through oxidative stress and energy metabolism pathway.

Cepharanthine (CEP), a bioactive compound derived from Stephania Cephalantha Hayata, is cytotoxic to various malignancies. However, the underlying mechanism of gastric cancer is unknown. CEP inhibited the cellular activity of gastric cancer AGS, HGC27 and MFC cell lines in this study.

Metabolomics analysis of the antidepressant prescription Danzhi Xiaoyao Powder in a rat model of Chronic Unpredictable Mild Stress (CUMS).

Ethnopharmacological Relevance: Danzhi Xiaoyao Powder (DZXY) is a classical prescription, that has been extensively used in traditional Chinese medicine (TMC) to treat depression for many years. However, the mechanism of DZXY is still unclear.

Aim Of The Study: The aim was to investigate the mechanism of the antidepressant effect of DZXY on a rat model of chronic unpredictable mild stress (CUMS).

Simultaneous Determination of Parecoxib and Its Metabolite Valdecoxib Concentrations in Beagle Plasma by UPLC-MS/MS and Application for Pharmacokinetics Study.

A method for the simultaneous determination of parecoxib and its metabolite valdecoxib in beagle plasma by UPLC-MS/MS was developed and validated. After the plasma was extracted by acetonitrile precipitation, the analytes were separated on an Acquity UPLC BEH C18 column (2.1 mm × 50 mm, 1.

Marital status is an independent prognostic factor in inflammatory breast cancer patients: an analysis of the surveillance, epidemiology, and end results database.

Objectives: The aim of this analysis was to study the impact of marital status on inflammatory breast cancer (IBC) patients, as the prognostic impact is yet to be studied in detail.

Methods: Data of IBC patients from 2004 to 2010 were sorted out from the database of surveillance, epidemiology, and end results (SEER), and overall survival (OS) rates and breast cancer-specific survival (CSS) rates were compared between a group of married and unmarried patients. The comparison was performed by Kaplan-Meier method with log-rank test, and multivariate survival analysis of CSS and OS was performed using the Cox proportional hazard model.

Clinicopathological characteristics and prognosis of pulmonary large cell neuroendocrine carcinoma aged ≥65 years.

Objective: The present study was designed to better characterize the clinicopathological features and prognosis in patients aged ≥65 years with pulmonary large cell neuroendocrine carcinoma (LCNEC).

Methods: Eligible patients with pulmonary LCNEC were retrieved from the Surveillance, Epidemiology, and End Results database between January 2004 and December 2013. The primary endpoints included cancer-specific survival (CSS) and overall survival (OS).

[Effects of urban wetlands with different shapes on the temperature and humidity of ambient environment.].

To quantify the effects of urban wetlands on temperature and humidity of ambient environment, five urban wetlands with different shapes and surroundings were selected in Daqing City, and the air temperature and relative humidity were investigated in spring, summer and autumn using small-scale quantitative measurement method. The results indicated that the urban wetlands with different shapes all could decrease the temperature and increase the humidity, with the effect being strongest in summer, followed by in spring, and the smallest effect in autumn. The shape of the urban wetland had significant effect on temperature and humidity, which decreased in the order of irregular-shaped wetland > regular-shaped wetland (subcircular-shaped wetland, subcuboid-shaped wetland) > long-shaped wetland.

Moderate hypofractionated radiotherapy is more effective and safe for localized prostate cancer patients: a meta-analysis.

To compare the efficacy and safety of moderate hypofractionated radiotherapy (H-RT) with those of conventional radiotherapy (C-RT) in patients with localized prostate cancer, we conducted extensive literature searches of The Web of Science, Embase, Pubmed and Cochrane Library databases. We identified nine studies with 5969 patients for a meta-analysis. We calculated pooled risk ratios (RRs) and the 95% confidence intervals (CIs) for multiple parameters and performed statistical analysis using RevMan 5.

[Effects of urban river width on the temperature and humidity of nearby green belts in summer].

As an important part of urban ecosystem, urban river plays a vital role in improving urban ecological environment. By the methods of small scale quantitative measurement, this paper analyzed the effects of seven urban rivers with different widths along the Third to Fifth Ring in Beijing on the air temperature and relative humidity of nearby green belts. The results showed that urban river width was the main factor affecting the temperature and humidity of nearby green belts.

[Relationships between urban green belt structure and temperature-humidity effect].

Taking four green belts with different internal constitutions and five green belts with different canopy densities along the west fourth ring road of Beijing as test objects, and by using small-scale quantitative measurement method, this paper studied the relationships between different structure urban green belts (width 42 m) and temperature-humidity effect in Beijing. Comparing with the control, lawn had no obvious effect on the decrease of air temperature and the increase of relative humidity, while shrub-herbage, tree-shrub-herbage, and tree-herbage had significant effect. When the canopy density was 10%-31%, green belts had definite effect on the decrease of air temperature and the increase of relative humidity; when the canopy density reached 44%, the effect became significant; and when the canopy density exceeded 67%, the effect was significant and stable.