Background: Colorectal cancer (CRC) poses a significant public health challenge in Canada, with the Atlantic provinces bearing a particularly high burden. The implementation of population-based colon screening programs is aimed to address this concern. However, limited research exists on the effect of these programs especially in Canada.
View Article and Find Full Text PDFThis study aims to develop a machine learning model applied on digital mammograms to reduce unnecessary invasive biopsies for suspicious calcifications classified as BI-RADS category 4. This study retrospectively analyzed data from 372 female patients with pathologically confirmed BI-RADS category 4 mammographic calcifications. Patients from the First Affiliated Hospital of Bengbu Medical College (n = 275) were divided chronologically into a training and internal validation set.
View Article and Find Full Text PDFWhile cobalt metal is recognized as a versatile catalyst in various chemical reactions, such as Fischer-Tropsch synthesis, limited attention has been paid to understanding the detailed adsorptive interactions between water molecules and cobalt metal. In this study, we investigated the adsorption of water molecules on Co(0001) at 100 K using infrared reflection adsorption spectroscopy and low-energy electron diffraction. We experimentally revealed, for the first time, that DO adsorbed intact on the Co(0001) surface forms hexamer islands with coexisting D-up and D-down geometries, in line with the "ice bilayer" model.
View Article and Find Full Text PDFBackground: The survival rate of patients with distant metastasis (DM) of papillary thyroid carcinoma (PTC) is significantly reduced. It is of great significance to find an effective method for early prediction of the risk of DM for formulating individualized diagnosis and treatment plans and improving prognosis. Previous studies have significant limitations, and it is still necessary to develop new models for predicting the risk of DM of PTC.
View Article and Find Full Text PDFIn recent years, free-space optical communication based on various vortex beams has gained significant attention due to its high channel capacity and low bit error rate (BER). To investigate a novel type of vortex beam (termed as gamma beam) and its application in free-space optical communication (FSO), a comprehensive analysis of its transmission performance in weak-to-strong non-Kolmogorov turbulence has been conducted for the first time. Based on the extended Rytov method, the propagation behaviors of the gamma beam via weak-to-strong non-Kolmogorov turbulent atmosphere is explored, revealing that gamma beams may outperform LG beams and HyGG beams in certain short links.
View Article and Find Full Text PDFFree-space optical communication based on orbital angular momentum (OAM) offers advantages such as high security, large information capacity, and high-speed transmission. However, turbulence can induce random perturbations to the wavefront, thereby affecting communication performance. Hence, accurately measuring turbulence intensity is crucial.
View Article and Find Full Text PDFIEEE J Biomed Health Inform
November 2024
The surgical management of extensive jugular foramen schwannomas presents a formidable challenge, aiming for gross total resection while minimizing complications. Here, we present a case with giant triple dumbbell-shaped jugular Foramen Schwannoma. A 45-year-old male with a one-year history of a left neck mass underwent surgery.
View Article and Find Full Text PDFHirschsprung's disease (HSCR) is a congenital enteric nervous system (ENS) disorder. Genetics cannot explain most sporadic cases. To explore the relationship between pathogen infection, autoantibodies, innate immune, and HSCR.
View Article and Find Full Text PDFBackground: Lupus nephritis (LN) is the most serious complication of systemic lupus erythematosus (SLE), and plasma exosomes may serve as a bridge. MicroRNAs (miRNAs) are abundant in exosomes, so this study aimed to explore the role of exosome-derived miRNA in the development of LN.
Methods: The publicly available data containing plasma exosomal miRNAs in SLE patients and healthy controls were researched, and differential expression and functional enrichment analysis of exosomal miRNA was conducted.
Autophagy is a highly conserved cellular program in eukaryotic cells which mediates the degradation of cytoplasmic components through the lysosome, also named the vacuole in plants. However, the molecular mechanisms underlying the fusion of autophagosomes with the vacuole remain unclear. Here, we report the functional characterization of a rice (Oryza sativa) mutant with defects in storage protein transport in endosperm cells and accumulation of numerous autophagosomes in root cells.
View Article and Find Full Text PDFBrucellosis and Tuberculosis, both of which are contagious diseases, have presented significant challenges to global public health security in recent years. Delayed treatment can exacerbate the conditions, jeopardizing patient lives. Currently, no vaccine has been approved to prevent these two diseases simultaneously.
View Article and Find Full Text PDFAs cancer incidence rises due to an aging population, the importance of precision medicine continues to grow. Antibody-drug conjugates (ADCs) exemplify targeted therapies by delivering cytotoxic agents to specific antigens. Building on this concept, researchers have developed antibody-oligonucleotide conjugates (AOCs), which combine antibodies with oligonucleotides to regulate gene expression.
View Article and Find Full Text PDFBackground: Epithelial-to-mesenchymal transition (EMT), cancer stem cells (CSCs), and colorectal cancer (CRC) therapy resistance are closely associated. Prior reports have demonstrated that sphingosine-1-phosphate (S1P) supports stem cells and maintains the CSC phenotype. We hypothesized that the EMT inducer SNAI1 drives S1P signaling to amplify CSC self-renewal capacity and chemoresistance.
View Article and Find Full Text PDFAdv Sci (Weinh)
November 2024
Intensive Crit Care Nurs
February 2025
Objective: To systematically assess the prevalence and risk factors for subsyndromal delirium (SSD) in the intensive care unit.
Design: A systematic reviewand meta-analysis.
Methodology: This systematic review and meta-analysis was conducted in eight databases, including PubMed, Web of Science, Ovid,Scopus, China Knowledge Resource Integrated Database, Wanfang Database,Weipu Database and Chinese Biomedical Database.