Publications by authors named "Zhu Yun"

Background: Colorectal cancer (CRC) poses a significant public health challenge in Canada, with the Atlantic provinces bearing a particularly high burden. The implementation of population-based colon screening programs is aimed to address this concern. However, limited research exists on the effect of these programs especially in Canada.

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  • A multi-index nomogram prediction model was developed to assess clinically significant prostate cancer by integrating PI-RADS V2.1 scores, quantitative MRI parameters, and clinical factors in a study involving over 2000 patients.
  • The model's effectiveness was evaluated using various statistical methods, including AUC (Area Under the Curve), revealing high sensitivity and specificity, particularly with two models: one combining PI-RADS and PSAD, and another that added ADCmean.
  • Validation results indicated strong performance in predicting CSPCa across both internal and external cohorts, with no significant difference found between predicted and actual probabilities, supporting the model's reliability.
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This study aims to develop a machine learning model applied on digital mammograms to reduce unnecessary invasive biopsies for suspicious calcifications classified as BI-RADS category 4. This study retrospectively analyzed data from 372 female patients with pathologically confirmed BI-RADS category 4 mammographic calcifications. Patients from the First Affiliated Hospital of Bengbu Medical College (n = 275) were divided chronologically into a training and internal validation set.

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While cobalt metal is recognized as a versatile catalyst in various chemical reactions, such as Fischer-Tropsch synthesis, limited attention has been paid to understanding the detailed adsorptive interactions between water molecules and cobalt metal. In this study, we investigated the adsorption of water molecules on Co(0001) at 100 K using infrared reflection adsorption spectroscopy and low-energy electron diffraction. We experimentally revealed, for the first time, that DO adsorbed intact on the Co(0001) surface forms hexamer islands with coexisting D-up and D-down geometries, in line with the "ice bilayer" model.

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  • Mitochondrial dysfunction plays a significant role in inflammatory bowel disease (IBD), yet there are limited reports on targeted treatments that address this issue.
  • Researchers developed a novel oral treatment called HA-Cr nanogel, which combines selenium and creatine to enhance mitochondrial energy metabolism and eliminate reactive oxygen species (ROS) specifically at inflammation sites.
  • The HA-Cr nanogel showed promising results in improving IBD symptoms by restoring mitochondrial function, reducing inflammatory macrophage activity, repairing gut mucosa, and supporting microbial health, suggesting a new avenue for IBD treatment.
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Background: The survival rate of patients with distant metastasis (DM) of papillary thyroid carcinoma (PTC) is significantly reduced. It is of great significance to find an effective method for early prediction of the risk of DM for formulating individualized diagnosis and treatment plans and improving prognosis. Previous studies have significant limitations, and it is still necessary to develop new models for predicting the risk of DM of PTC.

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In recent years, free-space optical communication based on various vortex beams has gained significant attention due to its high channel capacity and low bit error rate (BER). To investigate a novel type of vortex beam (termed as gamma beam) and its application in free-space optical communication (FSO), a comprehensive analysis of its transmission performance in weak-to-strong non-Kolmogorov turbulence has been conducted for the first time. Based on the extended Rytov method, the propagation behaviors of the gamma beam via weak-to-strong non-Kolmogorov turbulent atmosphere is explored, revealing that gamma beams may outperform LG beams and HyGG beams in certain short links.

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Free-space optical communication based on orbital angular momentum (OAM) offers advantages such as high security, large information capacity, and high-speed transmission. However, turbulence can induce random perturbations to the wavefront, thereby affecting communication performance. Hence, accurately measuring turbulence intensity is crucial.

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The surgical management of extensive jugular foramen schwannomas presents a formidable challenge, aiming for gross total resection while minimizing complications. Here, we present a case with giant triple dumbbell-shaped jugular Foramen Schwannoma. A 45-year-old male with a one-year history of a left neck mass underwent surgery.

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Hirschsprung's disease (HSCR) is a congenital enteric nervous system (ENS) disorder. Genetics cannot explain most sporadic cases. To explore the relationship between pathogen infection, autoantibodies, innate immune, and HSCR.

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Background: Lupus nephritis (LN) is the most serious complication of systemic lupus erythematosus (SLE), and plasma exosomes may serve as a bridge. MicroRNAs (miRNAs) are abundant in exosomes, so this study aimed to explore the role of exosome-derived miRNA in the development of LN.

Methods: The publicly available data containing plasma exosomal miRNAs in SLE patients and healthy controls were researched, and differential expression and functional enrichment analysis of exosomal miRNA was conducted.

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Autophagy is a highly conserved cellular program in eukaryotic cells which mediates the degradation of cytoplasmic components through the lysosome, also named the vacuole in plants. However, the molecular mechanisms underlying the fusion of autophagosomes with the vacuole remain unclear. Here, we report the functional characterization of a rice (Oryza sativa) mutant with defects in storage protein transport in endosperm cells and accumulation of numerous autophagosomes in root cells.

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Brucellosis and Tuberculosis, both of which are contagious diseases, have presented significant challenges to global public health security in recent years. Delayed treatment can exacerbate the conditions, jeopardizing patient lives. Currently, no vaccine has been approved to prevent these two diseases simultaneously.

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  • Inflammatory bowel disease (IBD) is marked by chronic inflammation in the digestive tract and involves blood vessel formation (angiogenesis) as a key factor in its progression.
  • Ginsenoside Rg3 from ginseng has anti-angiogenic effects but suffers from poor absorption in the body, prompting the development of a new delivery system using a thermosensitive hydrogel called Gel-Rg3, made with Pluronic F-127 and F-68.
  • Gel-Rg3 demonstrated better safety and effectiveness against IBD in lab tests and mouse models by promoting drug retention in the intestine and inhibiting harmful blood vessel formation, offering new treatment strategies for managing IBD.
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As cancer incidence rises due to an aging population, the importance of precision medicine continues to grow. Antibody-drug conjugates (ADCs) exemplify targeted therapies by delivering cytotoxic agents to specific antigens. Building on this concept, researchers have developed antibody-oligonucleotide conjugates (AOCs), which combine antibodies with oligonucleotides to regulate gene expression.

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  • Acute lower respiratory tract infections (ALRTIs), primarily caused by the human respiratory syncytial virus (RSV), are a major cause of death in young children globally.
  • A study sequenced 105 complete RSV genomes from 2017 to 2020, revealing that all RSVA sequences belonged to genotype ON1 and all RSVB sequences were of genotype BA9, with significant genetic variations noted.
  • The research highlighted numerous amino acid substitutions across various viral proteins, particularly in areas relevant to vaccine development, emphasizing its importance for future RSV prevention and control strategies.
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  • COPII vesicles are essential for transporting proteins from the endoplasmic reticulum (ER) to the Golgi apparatus in eukaryotic cells, but their functions in plants, particularly in rice seeds, are not fully understood.
  • The study identified the rice mutant gpa12, which is unable to export storage proteins from the ER, leading to abnormal protein accumulation, and found that it encodes a COPII protein, Sec13a, that is crucial for this process.
  • Additionally, researchers discovered that rice has two other Sec13 isoforms (Sec13b and Sec13c), which help maintain ER structure, highlighting the unique and overlapping roles of these proteins in regulating protein transport and ER morphology in rice endos
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Background: Epithelial-to-mesenchymal transition (EMT), cancer stem cells (CSCs), and colorectal cancer (CRC) therapy resistance are closely associated. Prior reports have demonstrated that sphingosine-1-phosphate (S1P) supports stem cells and maintains the CSC phenotype. We hypothesized that the EMT inducer SNAI1 drives S1P signaling to amplify CSC self-renewal capacity and chemoresistance.

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  • Lifespans in mammals can differ significantly, with developmental speed being inversely related to lifespan, suggesting early-life interventions (ELIs) could modify aging patterns.
  • This review examines how various postnatal interventions in mice, such as diet changes and chemical treatments, impact development and lifespan, highlighting significant changes in aging processes.
  • Understanding the complexities of ELI research requires careful experimental design and attention to factors like timing and sex differences, which can inform future strategies for promoting healthy aging.
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  • The Omicron variant is the main type of COVID-19 affecting kids right now, and predicting how likely they are to survive in the hospital is important.
  • A study looked at data from 119 children with this variant to see if levels of certain blood substances (HCT and ALB) could help predict which kids were at higher risk of dying in the hospital.
  • Results showed that those with certain HCT-ALB levels were more likely to die, and researchers categorized patients into low, medium, and high-risk groups based on these levels, with higher risks leading to higher chances of death.
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  • A new deep learning model using quantum chemistry is developed to improve the prediction of DNA reaction parameters, enhancing both accuracy and efficiency.
  • The model combines quantum chemical calculations with custom descriptor matrices to account for energy changes and various influencing factors.
  • An active learning approach is used to address the lack of labeled data, resulting in better predictions of DNA hybridization free energies and strand displacement rates than current methods, contributing to the understanding and optimization of DNA systems.
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Objective: To systematically assess the prevalence and risk factors for subsyndromal delirium (SSD) in the intensive care unit.

Design: A systematic reviewand meta-analysis.

Methodology: This systematic review and meta-analysis was conducted in eight databases, including PubMed, Web of Science, Ovid,Scopus, China Knowledge Resource Integrated Database, Wanfang Database,Weipu Database and Chinese Biomedical Database.

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