Publications by authors named "Zhu Yichen"

Primary small cell carcinoma of the ovary is an extremely rare and highly malignant ovarian malignancy. The tissue origin of this type of cancer is still unclear, and it is characterized by rapid progression and a discouraging prognosis. The clinical presentation of small cell carcinoma of the ovary lacks specificity, and there are currently no effective treatment options available.

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Chimeric antigen receptor (CAR)-engineered T cell therapy holds promise for treating myeloid malignancies, but challenges remain in bone marrow (BM) infiltration and targeting BM-resident malignant cells. Current autologous CAR-T therapies also face manufacturing and patient selection issues, underscoring the need for off-the-shelf products. In this study, we characterize primary patient samples and identify a unique therapeutic opportunity for CAR-engineered invariant natural killer T (CAR-NKT) cells.

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Introduction: This study aimed to investigate the relationship between surgical difficulty and postoperative complications in kidney transplantation, as well as to develop a preoperative prediction model for assessing surgical difficulty.

Methods: This is a prospective cohort including 122 kidney transplant adult recipients. The subjective score for operative difficulty, ranging from 1 to 3 points, served as the quantitative measure of surgical difficulty.

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The clinical potential of current chimeric antigen receptor-engineered T (CAR-T) cell therapy is hampered by its autologous nature that poses considerable challenges in manufacturing, costs and patient selection. This spurs demand for off-the-shelf therapies. Here we introduce an ex vivo feeder-free culture method to differentiate gene-engineered hematopoietic stem and progenitor (HSP) cells into allogeneic invariant natural killer T (NKT) cells and their CAR-armed derivatives (CAR-NKT cells).

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Lead halide perovskites have garnered interest in light-emitting diode (LED) applications due to their strong emission and tunable properties. However, conventional synthesis methods involve energy-intensive thermal processes and hazardous organic solvents, raising environmental concerns. In this study, we report a simple and eco-friendly mechanochemical approach that produces phase-pure blue-emitting CsCuI (emission at 440 nm) and yellow-emitting CsCuI (emission at 570 nm) phosphors through polarity modulation and control of grinding duration.

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Unconventional T cells, including invariant natural killer T (iNKT) cells, gamma delta (γδ) T cells, and mucosal-associated invariant T (MAIT) cells, play important roles in both innate and adaptive immunity. These cells respond to tumors rapidly and influence the tumor microenvironment (TME). Recent advances in understanding their biology, as well as the development of novel therapeutic approaches, have underscored their potential in cancer immunotherapy.

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Article Synopsis
  • The study created and validated a nomogram to predict the risk of non-infectious fever (NIF) in patients after laparoscopic myomectomy using data from 576 patients.
  • It identified important risk factors for NIF, including the size and number of leiomyomas, preoperative hemoglobin levels, operative time, and estimated blood loss.
  • The nomogram proved accurate and can help doctors identify high-risk patients early, enabling better preventive care and management strategies.
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The micro-machining scale effect makes it challenging to forecast and control the process parameters of the micro-milling process, which makes the micro-flanking-milling of weak-rigidity micro-thin-walled parts prone to deformation. To determine the critical cutting parameters for chip formation in the micro-milling of curved thin-walled parts at the mesoscale, the strain-softening effect of titanium alloy during high-speed milling and the scale effect of mesoscale cutting were comprehensively considered and a finite element prediction model for curved micro-thin-wall micro-milling was established to determine the critical milling parameters for effective material removal. Based on the determined milling parameters, an experimental design of response surface optimization was carried out.

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The use of synthetic antigen-presenting cells to activate and expand engineered T cells for the treatment of cancers typically results in therapies that are suboptimal in effectiveness and durability. Here we describe a high-throughput microfluidic system for the fabrication of synthetic cells mimicking the viscoelastic and T-cell-activation properties of antigen-presenting cells. Compared with rigid or elastic microspheres, the synthetic viscoelastic T-cell-activating cells (SynVACs) led to substantial enhancements in the expansion of human CD8 T cells and to the suppression of the formation of regulatory T cells.

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  • The study aims to evaluate how effective endoscopic debridement combined with compression sutures is for treating aseptic olecranon bursitis in patients.
  • Researchers analyzed data from 28 patients and measured pain levels, elbow function, complications, recurrence, and scarring over an average follow-up period of around 12 months.
  • Results showed significant improvements in pain and elbow function post-surgery, with no recurrences or major complications, highlighting the treatment's benefits of being minimally invasive and facilitating quick recovery.
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Pain aversion is an avoidance response to painful stimuli. Previous research has indicated that the anterior cingulate cortex (ACC) is involved in pain aversion processing. However, as interneurons, the role of GABAergic neurons in the ACC (GABA neurons) in pain aversion is still unclear.

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Article Synopsis
  • - Researchers developed a new platform called graphene oxide antigen-presenting platform (GO-APP) to improve CAR T cell manufacturing, which is essential for effective cancer therapy.
  • - GO-APP effectively mimics the interactions between T cells and antigen-presenting cells, promoting significant T cell proliferation while maintaining their effectiveness in targeting cancer.
  • - The new system increased CAR T cell production over five times compared to standard methods and allowed T cells to produce their own interleukin-2, reducing dependency on external supplements for growth.
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Background: We aimed to introduce our modified hand-assisted retroperitoneoscopic living donor nephrectomy (HARPLDN) technique and define the learning curve.

Methods: One hundred thirty-eight kidney donors who underwent modified HARPLDN by the same surgeon between May 2015 and March 2022 were included. A cumulative sum (CUSUM) learning curve analysis was performed with the total operation time as the study outcome.

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Background: China experienced one of the largest spikes in COVID-19 several months ago, followed by multiple rounds of reinfections. COVID-19 predisposes to the development of acute kidney injury (AKI) which has a higher developing risk in organ transplant recipients. However, few studies reported multiple infections and changes in renal function in the kidney transplant population in China.

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Article Synopsis
  • A study examined factors affecting the difficulty of hand-assisted laparoscopic living donor nephrectomy and its connection to complications in both donors and recipients.
  • Researchers included 60 patients for the main analysis and 20 for validation, assessing surgical difficulty using a scoring system.
  • The study found that increased surgical difficulty led to more complications; key predictors of difficulty were the number of renal arteries, visceral fat thickness, and MAP score, leading to the development of a prediction model.
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Background: Hearing loss is a prevalent issue resulting from loud noise exposure, aging, diseases, and genetic differences. As individuals age, the likelihood of experiencing hearing loss and depression escalates; yet, the link between hearing loss and the risk of depression remains ambiguous. This study explores the relationship between hearing and depression risk, taking into account sociodemographic and health-related factors.

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Comorbid chronic neuropathic pain and anxiety is a common disease that represents a major clinical challenge. The underlying mechanisms of chronic neuropathic pain and anxiety are not entirely understood, which limits the exploration of effective treatment methods. Glutamatergic neurons in the ventrolateral periaqueductal gray (vlPAG) have been implicated in regulating pain, but the potential roles of the vlPAG in neuropathic pain-induced anxiety have not been investigated.

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Background And Aims: The role of serum branched-chain amino acids (BCAAs) in long-term liver cirrhosis complication events remains unclear. We aimed to evaluate the associations between serum BCAAs and the risk of liver-related events.

Methods: We included a total of 64,005 participants without liver cirrhosis complication events at baseline from the UK Biobank.

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Article Synopsis
  • Cancer immunotherapy using autologous CAR T cells is complicated by manufacturing and patient selection issues, but 'off-the-shelf' options like allogeneic CAR-NKT cells could simplify the process.
  • Researchers developed a new method to produce high-yield IL-15-enhanced CAR-NKT cells that target multiple cancers, showing effectiveness in battling multiple myeloma and removing immunosuppressive cells from tumors.
  • The CAR-NKT cells demonstrated a stable hypoimmunogenic profile, meaning they are less likely to cause harmful immune reactions, making them promising candidates for clinical use without severe side effects like graft versus host disease.
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The clinical potential of current FDA-approved chimeric antigen receptor (CAR)-engineered T (CAR-T) cell therapy is encumbered by its autologous nature, which presents notable challenges related to manufacturing complexities, heightened costs, and limitations in patient selection. Therefore, there is a growing demand for off-the-shelf universal cell therapies. In this study, we have generated universal CAR-engineered NKT (CAR-NKT) cells by integrating iNKT TCR engineering and HLA gene editing on hematopoietic stem cells (HSCs), along with an ex vivo, feeder-free HSC differentiation culture.

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Background: The risk of transplant recipient infection is unknown when the preservation solution culture is positive.

Methods: We developed a prediction model to evaluate the infection in kidney transplant recipients within microbial contaminated preservation solution. Univariate logistic regression was utilized to identify risk factors for infection.

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Aims: To explore whether music intervention improves the quality of life (QOL) of patients undergoing hematopoietic stem cell transplantation (HSCT) and to evaluate its impact on patients' symptoms of depression/anxiety and fatigue.

Methods: This systematic review and meta-analysis was conducted in accordance with the Preferred Reporting Items of Systematic reviews and Meta-Analyses (PRISMA) guidelines. The databases PubMed, Cochrane CENTRAL, and EMBASE were searched from inception to September 30, 2022.

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Purpose: To compare the efficiency and safety between retroperitoneal laparoscopic nephrectomy and traditional open nephrectomy to treat autosomal-dominant polycystic kidney disease before kidney transplantation.

Materials And Methods: A total of 57 patients diagnosed with huge autosomal-dominant polycystic kidney disease between 2000 and 2020 at our center were included in this study. Patients were divided into a retroperitoneal laparoscopic (RL; n=23) group and traditional open (TO; n = 34) group.

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Aims: Negative emotions induced by chronic pain are a serious clinical problem. Electroacupuncture (EA) is a clinically proven safe and effective method to manage pain-related negative emotions. However, the circuit mechanisms underlying the effect of EA treatment on negative emotions remain unclear.

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