Publications by authors named "Zhu Wu"

Objectives: This study aimed to evaluate the discordance in patient-physician assessment of psoriatic arthritis disease activity and its association with the patient's psychological health.

Methods: This cross-sectional study recruited 135 patients with PsA from Xiangya Hospital of China between October 2021 and July 2022. The visual analogue scale was used to assess the disease activity of PsA, and an absolute difference of ≥ 10 points between the patient-physician global assessment on visual analogue scale was regarded as a clinically relevant discordance.

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Several recent reports suggest that arylboronic esters can exhibit room temperature phosphorescence (RTP), an optical property that is desirable for applications in security printing, oxygen sensing, and bioimaging. These findings challenged the fundamental notion that heavy elements or changes in orbital symmetry were required for intersystem crossing to occur in organic compounds. As we had not observed long afterglow in the many arylboronic esters we had synthesized over many years, we suspected that the RTP observed in these systems had a simpler explanation: the materials reported were impure.

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Background: Despite the widespread adoption of video-assisted thoracoscopic surgery (VATS) for major lung resection, the 10-year long-term survival outcomes of non-small cell lung cancer (NSCLC) treated with VATS compared with open major lung resection is lacking. The purpose of this study was to analyze the short- and long-term outcomes of VATS open major lung resection for NSCLC.

Methods: The perioperative outcomes and long-term survival of p-stage I-III NSCLC patients who underwent major lung resection via VATS open major lung resection in the Western China Lung Cancer Database (WCLCD) between May 2006 and June 2018 were studied using propensity score matching (PSM).

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Recurrent miscarriage (RM) is a chronic and heterogeneous pregnancy disorder lacking effective treatment. Alterations at the maternal-fetal interface are commonly observed in RM, with the loss of certain cell subpopulations believed to be a key cause. Through single-cell sequencing of RM patients and healthy donors, we aim to identify aberrancy of cellular features in RM tissues, providing new insights into the research.

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Background: Evidence suggests a connection between DNA methylation (DNAm) aging and reproductive aging. However, the causal relationship between DNAm and age at menopause remains uncertain.

Methods: Employing established DNAm epigenetic clocks, such as DNAm Hannum age acceleration (Hannum), Intrinsic epigenetic age acceleration (IEAA), DNAm-estimated granulocyte proportions (Gran), DNAm GrimAge acceleration (GrimAgeAccel), DNAm PhenoAge acceleration (PhenoAgeAccel), and DNAm-estimated plasminogen activator inhibitor-1 levels (DNAmPAIadjAge), a bidirectional Mendelian randomization (MR) study was carried out to explore the potential causality between DNAm and menopausal age.

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Article Synopsis
  • Inflammatory skin diseases are linked to dyslipidaemia, and there's ongoing research on whether lipid-lowering drugs could serve as effective treatments.
  • This study used Mendelian randomisation to analyze the causal relationship between lipid-lowering drugs, specifically PCSK9 and HMGCR inhibitors, and common inflammatory skin diseases like psoriasis and atopic dermatitis.
  • Results showed that inhibiting PCSK9 significantly reduced the risk of psoriasis and atopic dermatitis, while HMGCR inhibition posed a higher risk for allergic urticaria and rosacea, suggesting PCSK9 inhibitors might be safer and more effective options for treating these skin conditions.
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Diabetes and its complications significantly affect individuals' quality of life. The etiology of diabetes mellitus and its associated complications is complex and not yet fully understood. There is an increasing emphasis on investigating the effects of endocrine disruptors on diabetes, as these substances can impact cellular processes, energy production, and utilization, ultimately leading to disturbances in energy homeostasis.

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Objective: To construct a predictive model for Psoriatic Arthritis (PsA) based on clinical and ultrasonic characteristics in patients with plaque psoriasis (PsP).

Patients And Methods: Demographic, clinical, and ultrasound data were collected from patients with PsP and PsA between May 2019 and December 2022.

Results: A total of 212 patients with PsP and 123 with PsA in the training cohort, whereas the validation cohort comprised 91 patients with PsP and 49 with PsA.

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Article Synopsis
  • - Pathological scars, like hypertrophic scars and keloids, are caused by excessive fibroblast activity and collagen buildup, leading to pain, itching, and psychological distress for patients.
  • - Researchers developed 5-fluorouracil (5-Fu) loaded liposomes (5-Fu-Lip) to enhance the delivery and effectiveness of 5-Fu for treating these scars, overcoming issues of limited drug penetration.
  • - 5-Fu-Lip demonstrated better results in reducing fibroblast activity and scar severity compared to traditional 5-Fu, suggesting it could be a more effective treatment option for pathological scars.
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Psoriasis is an immune-mediated, chronic, relapsing, inflammatory, systemic disease induced by individual-environmental interactions, and is often lifelong because of the difficulty of treatment. In recent years, a variety of targeted therapies, including biologics, have improved the lesions and quality of life of most psoriasis patients, but they still do not address the problem of relapse and may be associated with decreased efficacy or adverse events such as infections over time. Therefore, there is an urgent need for breakthroughs in psoriasis treatment and in relapse-delaying and non-pharmacologic strategies, and stem cell therapy for psoriasis has emerged.

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Psoriasis is a common inflammatory systemic disease characterized by pro-inflammatory macrophages activation (M1 macrophage) infiltrated in the dermal layer. How M1 macrophage contributes to psoriasis remains unknown. In this study, we found that adenosine A2A receptor (A2AR) agonist CGS 21680 HCl alleviated the imiquimod (IMQ) and mouse IL-23 Protein (rmIL-23)-induced psoriasis inflammation through reducing infiltration of M1.

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The disease severity of psoriasis is mainly assessed subjectively via  psoriasis area and severity index (PASI) and body surface area (BSA), while an optimal measure of cutaneous response, may overlook systemic inflammation in psoriasis patients. The neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), monocyte to lymphocyte ratio (MLR), monocyte to high density lipoprotein ratio (MHR), and systemic immune-inflammation index (SII) exhibit notable associations with the inflammation severity in multiple diseases. The aim of this retrospective study was to explore the associations between inflammatory parameters and the skin lesions' severity of psoriasis.

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Article Synopsis
  • The study compared the current Essen rabies immunization schedule (0-3-7-14-28) in China with the newly recommended 4-dose schedule (0-3-7-14) by the WHO, focusing on their safety and efficacy.
  • Mice were used to measure the effectiveness of both schedules in generating rabies virus neutralizing antibodies (RVNAs), and a clinical trial with 185 individuals was conducted to evaluate real-world outcomes.
  • Results indicated that the 4-dose schedule effectively produced RVNAs with a 100% positive conversion rate in humans, and delaying the fourth dose did not significantly impact immune response.
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Background: Treatment of scarring has long been a problem due to high incidence and recurrence. Despite many existing treatment therapies, the efficacy remains unstable.

Objectives: To determine the efficacy and safety of skin biopsy punch in combination with corticosteroid injection (BPCI) in treating keloids.

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Background: As one of the most effective biologic treatments for psoriasis, the short-term effectiveness of ustekinumab has yet to be studied extensively.

Objective: The purpose of this study was to evaluate the short-term effectiveness and potential factors within four weeks after the first-dose ustekinumab treatment based on real-world data.

Methods: The study enrolled 98 patients with moderate-to-severe psoriasis, given ustekinumab 45 mg at week 0, week 4, and then every 12 weeks.

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Linezolid is an oxazolidinone antibiotic that is active against drug-resistant Gram-positive bacteria and multidrug-resistant . Real-world studies on the safety of linezolid in large populations are lacking. This study aimed to determine the adverse events associated with linezolid in real-world settings by analyzing data from the US Food and Drug Administration (FDA) Adverse Event Reporting System (FAERS).

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Accurately extracting pixel-level buildings from high-resolution remote sensing images is significant for various geographical information applications. Influenced by different natural, cultural, and social development levels, buildings may vary in shape and distribution, making it difficult for the network to maintain a stable segmentation effect of buildings in different areas of the image. In addition, the complex spectra of features in remote sensing images can affect the extracted details of multi-scale buildings in different ways.

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Article Synopsis
  • Psoriasis is an inflammatory skin condition linked to overactive dendritic cells (DCs), which play a key role in the immune response, and BET inhibitors like NHWD-870 can help regulate this process.
  • In a study involving a psoriasis-like mouse model, NHWD-870 reduced skin inflammation and decreased markers of DC maturation, showing a significant improvement in symptoms.
  • The research also highlighted the role of interferon regulatory factor 7 (IRF7) in DC maturation, finding that NHWD-870 lowers IRF7 levels, suggesting its potential as a new treatment option for psoriasis.
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Purely organic materials exhibiting room temperature phosphorescence (RTP) are promising candidates for oxygen sensors and information encryption owing to their cost-effective and environmentally friendly nature. Herein, we report a bimolecular RTP system where DTBU acts as the guest and TBBU serves as the host. In contrast to previously reported results, we find that both pure DTBU and TBBU do not exhibit RTP in the solid state even under N atmosphere.

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Spermatogenesis is a developmental process driven by interactions between germ cells and Sertoli cells. This process depends on appropriate gene expression, which might be regulated by transcription factors. This study focused on , a zinc finger transcription factor, and explored its function and molecular mechanisms in spermatogenesis in a mouse model.

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Background: The rarity of metaplastic breast carcinoma (MBC) has resulted in limited sonographic data. Given the inferior prognosis of MBC compared to invasive ductal carcinoma (IDC), accurate preoperative differentiation between the two is imperative for effective treatment planning and prognostic prediction. The objective of this study was to assess the diagnostic accuracy of MBC and differentiate it from IDC by analyzing sonographic and clinicopathologic features.

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Background: The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on postoperative recovery of non-small cell lung cancer (NSCLC) is need to be understood, thereby informing the optimal timing of surgical decision-making during the COVID-19 pandemic for NSCLC patients. This study reports the postoperative outcomes of surgical NSCLC patients with preoperative SARS-CoV-2 infection.

Method: This single-center retrospective cohort study included 241 NSCLC patients who underwent lobectomy or sub-lobectomy between December 1, 2022 and February 14, 2023.

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Although a peak incidence of psoriasis in women aged around 60 years has been observed, the link between reproductive lifespan and late-onset psoriatic diseases is underexplored. This study aims to elucidate the association between reproductive lifespan and the risk of late-onset psoriasis and psoriatic arthritis (PsA). Utilizing the UK Biobank data, we conducted a prospective cohort study in postmenopausal women without baseline psoriatic diseases.

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