Pyridine-hydrazone-controlled cyanide detection in aqueous media and solid-state: tuning the excited-state intramolecular proton transfer (ESIPT) fluorescence modulated by intramolecular NHBr hydrogen bonding.

A new efficient pyridine-hydrazone-substituted naphthalimide receptor 4a-E has been synthesized as a selective colorimetric and fluorescent chemosensor for cyanide sensing in aqueous environments through a unique excited-state intramolecular proton transfer (ESIPT) mechanism. The addition of a Br group to the fluorophore skeleton at the ortho-position of hydrazone generates reference compounds (4b-E and 4c-Z). Interestingly, the potential intramolecular NHBr hydrogen bonding might compete with the anion-induced intermolecular NHA- hydrogen bonding, resulting in dramatic ESIPT suppression.

JAK2 and PTPRC mRNA expression in peripheral blood mononuclear cells from patients with systemic lupus erythematosus.

In this study, we aimed to explore the expression levels of JAK2 and PTPRC in peripheral blood mononuclear cells (PBMCs) from SLE patients and controls, detect the effects of SLE activity on genes mRNA expression, and find the association between genes mRNA expression and clinical manifestations of patients. We performed quantitative real-time PCR (qRT-PCR) to test differences in the expression levels of JAK2 and PTPRC in PBMCs extracted from 135 patients with SLE and 130 healthy controls. Furthermore, we detected the regulatory effect of SNPs on gene expression by expression quantitative trait loci (eQTL).

Association between infection and kidney damage in patients with peptic ulcer.

() is relevant to several renal diseases. Our previous research indicates that cytotoxin-associated gene A (CagA) of increases secretion of serum immunoglobulin A1 (IgA1) and induces the underglycosylation of IgA1, one of the key factors causing IgA nephropathy. Here, we aimed to study the correlation between infection and kidney damage in patients with peptic ulcer, and evaluate the effect of eradication on kidney damage.

Early warning score adjusted for age to predict the composite outcome of mortality, cardiac arrest or unplanned intensive care unit admission using observational vital-sign data: a multicentre development and validation.

Objectives: Early warning scores (EWS) alerting for in-hospital deterioration are commonly developed using routinely collected vital-sign data from the whole in-hospital population. As these in-hospital populations are dominated by those over the age of 45 years, resultant scores may perform less well in younger age groups. We developed and validated an age-specific early warning score (ASEWS) derived from statistical distributions of vital signs.

PADI3 plays an antitumor role via the Hsp90/CKS1 pathway in colon cancer.

Background: CKS1 is highly expressed in colon cancer tissues, and is essential for cancer cell proliferation. The downstream molecular mechanism of CKS1 has been fully studied, but the upstream regulatory mechanism of it is still unclear. Earlier research found that PADI3 plays its anti-tumor roles via suppress cell proliferation, in this study, we found that the expression pattern of PADI3 and CKS1 are negatively correlated in colon cancer tissues, and overexpression of PADI3 can partly reverse CKS1 induced cancer cell proliferation.

X-ray total scattering study of magic-size clusters and quantum dots of cadmium sulphide.

Four types of magic-size CdS clusters and three different CdS quantum dots have been studied using the technique of X-ray total scattering and pair distribution function analysis. We found that the CdS quantum dots could be modelled as a mixed phase of atomic structures based on the two bulk crystalline phases, which is interpreted as representing the effects of random stacking of layers. However, the results for the magic-size clusters are significantly different.

Cumulative evidence for association of sepsis and retinopathy of prematurity.

Background: Retinopathy of prematurity (ROP) is a retinal vasoproliferative disease affected by multiple factors such as infection and preterm birth. The role of sepsis in the development of ROP remains controversial. This systematic review and meta-analysis aimed to identify the impact of sepsis on ROP.

T cells redirected against Igβ for the immunotherapy of B cell lymphoma.

CD19-redirected CAR-T immunotherapy has emerged as a promising strategy for treatment of B cell lymphoma, however, many patients often relapsed due to antigen loss. Therefore, it is urgently needed to explore other suitable antigens targeted by CAR-T cells to cure B cell lymphoma. Igβ is a component of the B cell receptor (BCR) complex, which is highly expressed on the surface of lymphoma cells.

Wnt/β-catenin signaling pathway regulates asthma airway remodeling by influencing the expression of c-Myc and cyclin D1 via the p38 MAPK-dependent pathway.

Airway remodeling is the main characteristic of asthma; however, the mechanisms underlying this pathophysiological change have not been fully elucidated. Previous studies have indicated that the Wnt/β-catenin and mitogen-activated protein kinase (MAPK) signaling pathway are involved in the development of airway remodeling during asthma. Therefore, the present study established an airway remodeling rat model, after which β-catenin, cyclin D1 and c-Myc protein expressions were analyzed via western blotting in the lung tissue and airway smooth muscle cells (ASMCs) of rats.

Reinjection oilfield wastewater treatment using bioelectrochemical system and consequent corrosive community evolution on pipe material.

The corrosive issues are comprehensively caused in oilfield rejection system, in which sulfide is one of (bio-)chemical factors leading to high corrosive rate and blocking problem. Generally, aerobic treatment is a well-established and cost-effective unit for sulfide removal before oilfield wastewater reinjection. However, the residual dissolved oxygen (DO), which causes chemical, biological and electrochemical corrosion to water injection pipeline equipment, is still high after multi-stage filtration of DO removal.

Ultra-High Performance of Hyper-Crosslinked Phosphate-Based Polymer for Uranium and Rare Earth Element Adsorption in Aqueous Solution.

In this work, a new type of hyper-crosslinked phosphate-based polymer (HCPP) polymerized by bis(2-methacryloxyethyl)phosphate has been developed for uranium and rare earth element (REE) extraction in an aqueous solution. The influence of the pH value, contact time, initial concentration, temperature, and competing ions on uranium adsorption of HCPP is investigated in detail. HCPP exhibits a maximum uranium adsorption capacity of up to 800 mg g at pH = 6.

Screening of Early Diagnostic Markers of Gentamicin-induced Acute Kidney Injury in Canines.

Introduction: The value of neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule-1 (Kim-1), and liver-type fatty acid binding protein (L-FABP) was assessed in early diagnosis of gentamicin-induced acute kidney injury (AKI) in dogs.

Material And Methods: Subcutaneous gentamicin injection in 16 healthy adult beagles made the AKI model. Blood was sampled every 6 h to detect NGAL, Kim-1, L-FABP, and serum creatinine (SCr) concentrations.

Repeated intravenous administration of silica nanoparticles induces pulmonary inflammation and collagen accumulation via JAK2/STAT3 and TGF-β/Smad3 pathways in vivo.

Background: The health hazards of silica nanoparticle (SiNP) are raising worldwide concern as SiNPs has become the second largest manufactured nanomaterial in global markets. However, insufficient data for the adverse health effects and safety evaluation of SiNPs are remaining a big question.

Purpose: We evaluated the effects and related mechanism of SiNPs on pulmonary inflammation and collagen production through repeated intravenous administration in mice in a 45-day observation period.

Identification and evolutionary analysis of chalcone isomerase-fold proteins in ferns.

The distribution of type I and II chalcone isomerases (CHIs) in plants is highly family specific. We have previously reported that ancient land plants, such as the liverworts and Selaginella moellendorffii, harbor type II CHIs. To better understand the function and evolution of CHI-fold proteins, transcriptomic data obtained from 52 pteridophyte species were subjected to sequence alignment and phylogenetic analysis.

Deep Interpretable Early Warning System for the Detection of Clinical Deterioration.

Assessment of physiological instability preceding adverse events on hospital wards has been previously investigated through clinical early warning score systems. Early warning scores are simple to use yet they consider data as independent and identically distributed random variables. Deep learning applications are able to learn from sequential data, however they lack interpretability and are thus difficult to deploy in clinical settings.

Bacillus cereus s-EPS as a dual bio-functional corrosion and scale inhibitor in artificial seawater.

In this study, soluble extracellular polymeric substances (s-EPS) secreted by Bacillus cereus (B. cereus) were studied as a novel, dual bio-functional corrosion and scale inhibiting material, in artificial seawater. Static tests showed that the scale inhibition efficiency (SI%) was close to 87.

Altered Functional Connectivity within Default Mode Network in Patients with Transient Ischemic Attack: A Resting-State Functional Magnetic Resonance Imaging Study.

Default mode network (DMN) is an important functional brain network that supports aspects of cognition. Stroke has been reported to be associated with functional connectivity (FC) impairments within DMN. However, whether FC within DMN changes in transient ischemic attack (TIA), an important risk factor for stroke, remains unclear.

A novel drug delivery system of mixed micelles based on poly(ethylene glycol)-poly(lactide) and poly(ethylene glycol)-poly(ɛ-caprolactone) for gambogenic acid.

In this study, a novel mixed polymeric micelles formed from biocompatible polymers, poly(ethylene glycol)-poly(lactide) (mPEG-PLA) and poly(ethylene glycol)-poly(ɛ-caprolactone) (mPEG-PCL), used as a novel nanocarrier to encapsulate gambogenic acid (GNA). GNA-loaded mixed polymeric micelles (GNA-MMs) was prepared by cosolvent evaporation method. The mean average size of GNA-MMs was (83.

Baicalein inhibits proliferation and collagen synthesis of mice fibroblast cell line NIH/3T3 by regulation of miR-9/insulin-like growth factor-1 axis.

The aberrant scar is a challenging problem. Baicalein has effects in attenuating hypertrophic scar formation. Herein, the roles of baicalein in NIH-3T3 were obtained.

Status and influencing factors of diabetes information acquisition among rural elderly with pre-diabetes in Yiyang City, China: a cross-sectional study.

Objective: This study was designed to investigate the status of diabetes information acquisition and its influencing factors among patients, 60 years and older, with pre-diabetes in rural China.

Design: This is a cross-sectional study.

Setting: The survey was conducted in 42 rural communities in Yiyang City, Hunan Province, China.

The efficiency of migration and profile control with emulsion systems in class III reservoirs.

In order to reveal the migration law and profile control efficiency of the emulsion system in the core of class III reservoir (the permeability less than 100 mD), the influence of the size and distribution of the droplets, the effect of the migration law and the adjustment of the interlayer contradiction to class III reservoir are studied in this paper. By measuring the droplet distribution in the emulsion system, we found that the average droplet diameter decreases with the increase in water cut. But, the droplet distribution is the most uniform when the water cut is 50%, which is the transition point of the emulsion.

Paraquat Preferentially Induces Apoptosis of Late Stage Effector Lymphocyte and Impairs Memory Immune Response in Mice.

Paraquat (PQ) is a toxic non-selective herbicide. To date, the effect of PQ on memory immune response is still unknown. We investigated the impact of PQ on memory immune response.

Rapid evolution of α-gliadin gene family revealed by analyzing Gli-2 locus regions of wild emmer wheat.

α-Gliadins are a major group of gluten proteins in wheat flour that contribute to the end-use properties for food processing and contain major immunogenic epitopes that can cause serious health-related issues including celiac disease (CD). α-Gliadins are also the youngest group of gluten proteins and are encoded by a large gene family. The majority of the gene family members evolved independently in the A, B, and D genomes of different wheat species after their separation from a common ancestral species.

A novel STAT3 inhibitor, HJC0152, exerts potent antitumor activity in glioblastoma.

Aberrant expression and activation of signal transducer and activator of transcription 3 (STAT3) is implicated in several malignancies, including glioblastoma, and is correlated with poor outcomes in patients with glioblastoma, rendering STAT3 a potential therapeutic target. However, few STAT3 inhibitors have been approved for clinical use. We recently developed an orally active small-molecule compound with anti-STAT3 activity, HJC0152.