METTL3-induced lncARSR aggravates neuroblastoma tumorigenic properties through stabilizing PHOX2B.

Neuroblastoma (NB), the most common extracranial solid tumor in pediatric patients, manifests with considerable variability across multiple primary sites. Despite this, the extent of genetic heterogeneity within these tumor foci and the identification of consistent oncogenic drivers remains largely unexplored. Of particular interest, genetic mutations in PHOX2B have been linked to familial cases of NB, yet the underlying molecular mechanisms are not fully delineated.

(Basidiomycota, Mycenaceae), a new species of sect. from China.

Background: (Pers.) Roussel (1806) is a large genus of Mycenaceae known for having small to medium-sized basidiomata. It is typified by the species (Scop.

Effect of fear of missing out on learning burnout in medical students: a moderated mediation.

Introduction: Learning burnout has a significant negative impact on students' academic performance and professional development, which has been exacerbated by the growing trend of problematic smartphone use, such as smartphone addiction, among young people. Recently, the literature on excessive social media use has revealed a critical role of fear of missing out. Objective The purpose of this study was to examine how fear of missing out affects smartphone addiction and its subsequent effect on learning burnout in college students.

Machine Learning of Functional Connectivity to Biotype Alcohol and Nicotine Use Disorders.

Background: Magnetic resonance imaging provides noninvasive tools to investigate alcohol use disorder (AUD) and nicotine use disorder (NUD) and neural phenotypes for genetic studies. A data-driven transdiagnostic approach could provide a new perspective on the neurobiology of AUD and NUD.

Methods: Using samples of individuals with AUD (n = 140), individuals with NUD (n = 249), and healthy control participants (n = 461) from the UK Biobank, we integrated clinical, neuroimaging, and genetic markers to identify biotypes of AUD and NUD.

Identifying alcohol misuse biotypes from neural connectivity markers and concurrent genetic associations.

Alcohol use behaviors are highly heterogeneous, posing significant challenges to etiologic research of alcohol use disorder (AUD). Magnetic resonance imaging (MRI) provides intermediate endophenotypes in characterizing problem alcohol use and assessing the genetic architecture of addictive behavior. We used connectivity features derived from resting state functional MRI to subtype alcohol misuse (AM) behavior.

Perceived stress, self-efficacy, and the cerebral morphometric markers in binge-drinking young adults.

Studies have identified cerebral morphometric markers of binge drinking and implicated cortical regions in support of self-efficacy and stress regulation. However, it remains unclear how cortical structures of self-control play a role in ameliorating stress and alcohol consumption or how chronic alcohol exposure alters self-control and leads to emotional distress. We examined the data of 180 binge (131 men) and 256 non-binge (83 men) drinkers from the Human Connectome Project.

An Efficient Algorithm for Deep Stochastic Contextual Bandits.

In stochastic contextual bandit (SCB) problems, an agent selects an action based on certain observed context to maximize the cumulative reward over iterations. Recently there have been a few studies using a deep neural network (DNN) to predict the expected reward for an action, and the DNN is trained by a stochastic gradient based method. However, convergence analysis has been greatly ignored to examine whether and where these methods converge.

OctSurf: Efficient hierarchical voxel-based molecular surface representation for protein-ligand affinity prediction.

Voxel-based 3D convolutional neural networks (CNNs) have been applied to predict protein-ligand binding affinity. However, the memory usage and computation cost of these voxel-based approaches increase cubically with respect to spatial resolution and sometimes make volumetric CNNs intractable at higher resolutions. Therefore, it is necessary to develop memory-efficient alternatives that can accelerate the convolutional operation on 3D volumetric representations of the protein-ligand interaction.

Communication-Optimal Distributed Dynamic Graph Clustering.

We consider the problem of clustering graph nodes over large-scale dynamic graphs, such as citation networks, images and web networks, when graph updates such as node/edge insertions/deletions are observed distributively. We propose communication-efficient algorithms for two well-established communication models namely the message passing and the blackboard models. Given a graph with nodes that is observed at remote sites over time [1, ], the two proposed algorithms have communication costs () and ( + ) ( hides a polylogarithmic factor), almost matching their lower bounds, Ω() and Ω ( + ), respectively, in the message passing and the blackboard models.

Bone marrow mesenchymal stem cells modified by angiogenin-1 promotes tissue repair in mice with oxygen-induced retinopathy of prematurity by promoting retinal stem cell proliferation and differentiation.

Retinopathy has become one of the major factors that lead to blindness worldwide. Although many clinical therapies are concerned about such disease, most of them focus on symptoms alleviation. In this study, we aim to investigate whether coculture retinal stem cells (RSCs) with bone marrow mesenchymal stem cells transfected with angiogenin-1 (Ang-1-BMSCs) affects the damaged retinal tissue of oxygen-induced retinopathy of prematurity (OIR-ROP) mice.

Characterization and source apportionment of size-segregated atmospheric particulate matter collected at ground level and from the urban canopy in Tianjin.

To investigate the size distributions of chemical compositions and sources of particulate matter (PM) at ground level and from the urban canopy, a study was conducted on a 255 m meteorological tower in Tianjin from December 2013 to January 2014. Thirteen sets of 8 size-segregated particles were collected with cascade impactor at 10 m and 220 m. Twelve components of particles, including water-soluble inorganic ions and carbonaceous species, were analyzed and used to apportion the sources of PM with positive matrix factorization.

Vertical characteristics of levels and potential sources of water-soluble ions in PM₁₀ in a Chinese megacity.

To investigate the vertical characteristics of ions in PM10 as well as the contributions and possible locations of their sources, eight water-soluble ions were measured at four heights simultaneously along a meteorological tower in Tianjin, China. The total ion concentrations showed a general decreasing trend with increasing height, ranging from 64.94μgm(-3) at 10m to 44.

Determination of buffering capacity of total suspended particle and its source apportionment using the chemical mass balance approach.

The samples of total suspended particle (TSP) from sources and TSP in the ambient atmosphere were collected in 2006 at Tianjin, People's Republic of China and analyzed for 16 chemical elements, two water-soluble ions, total carbon, and organic carbon. On the basis of the chemical mass balance (CMB) model, the contributions of different TSP sources to the ambient TSP were identified. The results showed that resuspended dust has the biggest contributions to the concentration of ambient TSP.

Application of activated carbon derived from scrap tires for adsorption of Rhodamine B.

Activated carbon derived from solid hazardous waste scrap tires was evaluated as a potential adsorbent for cationic dye removal. The adsorption process with respect to operating parameters was investigated to evaluate the adsorption characteristics of the activated pyrolytic tire char (APTC) for Rhodamine B (RhB). Systematic research including equilibrium, kinetics and thermodynamic studies was performed.

Synthesis and the effect of calcination temperature on the physical-chemical properties and photocatalytic activities of Ni,La codoped SrTiO3.

A series of highly vis-light active Ni,La-codoped SrTiO(3) photocatalysts were successfully synthesized with sol-gel process. The characterization results show that the calcination temperature has a strong influence on the physical-chemical properties of as-synthesized photocatalysts. The surface area and porosity, even the initial adsorption rate for malachite green (MG), decreased with increasing calcination temperature.

Crucial role of interleukin-7 in T helper type 17 survival and expansion in autoimmune disease.

Interleukin-7 receptor (IL-7R) is genetically associated with susceptibility to multiple sclerosis. Here we describe that IL-7 is essential for survival and expansion of pathogenic T helper type 17 (T(H)17) cells in experimental autoimmune encephalomyelitis (EAE). IL-7 directly expanded effector T(H)17 cells in EAE and human T(H)17 cells from subjects with multiple sclerosis, whereas it was not required for T(H)17 differentiation.

Secondary organic carbon quantification and source apportionment of PM10 in Kaifeng, China.

During 2005, the filter samples of ambient PM10 from five sites and the source samples of particulate matter were collected in Kaifeng, Henan Province of China. Nineteen elements, water-soluble ions, total carbon (TC) and organic carbon (OC) contained in samples were analyzed. Seven contributive source types were identified and their contributions to ambient PM10 were estimated by chemical mass balance (CMB) receptor model.

Use of a nonnegative constrained principal component regression chemical mass balance model to study the contributions of nearly collinear sources.

In this study, a nonnegative constrained principal component regression chemical mass balance (NCPCRCMB) model was used to solve the near collinearity problem among source profiles for source apportionment. The NCPCRCMB model added the principle component regression route into the CMB model iteration. The model was tested with the synthetic data sets, which involved contributions from eleven actual sources, with a serious near collinearity problem among them.

Chemical and stable carbon isotopic characterization for PAHs in aerosol emitted from two indoor sources.

Polycyclic aromatic hydrocarbons (PAHs) are with great environmental concerns due to their toxic, mutagenic, and carcinogenic properties. The harmful effects caused by PAHs emitted from indoor sources may be more direct and serious. In this study, PAHs in aerosol from two typical indoor sources, the cooking fume (CF) and environmental tobacco smoke (ETS) were collected by simulation emission in a chamber.

Using geoaccumulation index to study source profiles of soil dust in China.

Source apportionment studies of TSP (atmospheric particulate matter with aerodynamic diameters < or = 100 microm) and PM10 (atmospheric particulate matter with aerodynamic diameters < or = 10microm) have revealed that soil dust is an important source of these particulates in China. In this study, the contamination of soil dust was assessed through the use of a geoaccumulation index (I(geo)). The mass concentration profiles of 17 elements (Na, Mg, Al, K, Ca, Ti, V, Cr, Mn, Fe, Co, Ni, Cu, Zn, Br, Ba, and Pb) were established for urban soil dusts.

Occurrence and behavior of four of the most used sunscreen UV filters in a wastewater reclamation plant.

Four UV filters, benzophenone-3 (BP-3), 4-methylbenzylidence camphor (4-MBC), ethylhexyl methoxycinnamate (EHMC), and octocrylene (OC), have been examined along the different units of a wastewater reclamation plant (WWRP) located in Tianjin, North China. The analytical procedure included solid-phase extraction and gas chromatographic/mass spectrometric analyses. All four UV filters were detected in the influent during the three sampling campaigns (February, July, and September), and the concentrations ranged from 34 to 2128 ng L(-1).

Health risk assessment for traffic policemen exposed to polycyclic aromatic hydrocarbons (PAHs) in Tianjin, China.

In China, traffic policemen have to stand for several hours a day at the road intersections with high vehicle flows. To assess their exposure to airborne carcinogenic polycyclic aromatic hydrocarbons (PAHs) during their working time, a preliminary study was conducted to measure the personal exposure level to PAHs. And a probabilistic incremental lifetime cancer risk (ILCR) model together with the benzo[a]pyrene (BaP) toxic equivalents (BaP(eq)) method was used to conduct health risk assessment.

Source apportionment of ambient total suspended particulates and coarse particulate matter in urban areas of Jiaozuo, China.

Approximately 750 total suspended particulates (TSPs) and coarse particulate matter (PM10) filter samples from six urban sites and a background site and >210 source samples were collected in Jiaozuo City during January 2002 to April 2003. They were analyzed for mass and abundances of 25 chemical components. Seven contributive sources were identified, and their contributions to ambient TSP/PM10 levels at the seven sites in three seasons (spring, summer, and winter days) and a "whole" year were estimated by a chemical mass balance (CMB) receptor model.

Source analysis of particulate-phase polycyclic aromatic hydrocarbons in an urban atmosphere of a northern city in China.

Particle-associated polycyclic aromatic hydrocarbon (PAH) concentrations were investigated at six sampling sites in the heating (February to March 2001) and nonheating (August to September 2001) periods in an industrial city in Northern China. Thirteen PAHs were measured. The total average concentrations (nanograms per meter cubed) of PAHs ranged between 78.