Isoquinoline alkaloids with bioactive constituents from the roots and rhizomes of .

Isoquinoline alkaloids are important effective chemical components separated from the , which were mostly reported as planar structures. By using chiral HPLC, we have concluded that some natural isoquinoline alkaloids exist as enantiomeric mixtures, providing a novel direction for future research on isoquinoline alkaloids. Finally, three pairs of enantiomeric isoquinoline alkaloids (, including five undescribed compounds-, and ), together with another eight known isoquinoline alkaloids () were isolated from the roots and rhizomes of .

Unveiling the effect of codoping in strontium ferrite for oxygen evolution in alkaline media.

Co and Ni codoped strontium ferrite particles were prepared by a solid-state strategy and employed as catalysts for the OER. They exhibited a Tafel slope of 55 mV dec and required an overpotential of 334 mV to afford a current density of 10 mA cm, which is lower than that of Co and Ni separately doped samples. The DFT calculations reveal the redistribution of local charge around Fe atoms, decrease of energy barriers, and increase of conductivity by doping.

Central retinal artery occlusion following surgery for thyroid eye disease: A case report.

Rationale: Thyroid eye disease (TED) is the most common orbital disorder in adults and significantly affects patient health. Orbital decompression surgery is an important treatment option. Central retinal artery occlusion (CRAO) after orbital medial wall decompression is rare in patients with TED.

High-performance silk/polylactic acid composite scaffold material with immunomodulation and osteogenesis function.

The choice of suitable materials and effective structural design are crucial in influencing the therapeutic outcomes of bone tissue engineering scaffolds. This study introduces a controllable biodegradable composite scaffold composed of flat silkworm cocoon (FSC) and polylactic acid (PLA) as an innovative strategy for promoting bone healing in complex injuries. We focused on optimizing the scaffold's structural design, mechanical properties, and underlying mechanisms of osteogenesis.

Naphthoquinone-derived ZSW-4B induces apoptosis in triple-negative breast cancer via AMPK signalling activation.

Triple-negative breast cancer (TNBC) is the most malignant molecular subtype of breast cancer and is characterized by aggressiveness, high mortality, significant heterogeneity, and poor prognosis. AMPK plays a critical role in maintaining the cellular energy balance, and its inactivation is associated with malignant breast cancer. Here, we identified the pharmacological mechanism of the 1,4-naphthoquinone derivative ZSW-4B.

NEFL Modulates NRN1-Mediated Mitochondrial Pathway to Promote Diacetylmorphine-Induced Neuronal Apoptosis.

Diacetylmorphine abuse is a major social problem that jeopardizes the world, and abuse can cause serious neurological disorders. Apoptosis plays an important role in neurological diseases. A previous study by our group found that the brain tissue of diacetylmorphine-addicted rats showed severe vacuole-like degeneration and increased apoptosis, but the exact mechanism has not yet been reported.

Virus-bacterium interaction involved in element cycles in biological treatment of coking wastewater.

Although prokaryotic microbes in coking wastewater (CWW) treatment have been comprehensively studied, the ecological functions of viruses remain unclear. A full-scale CWW biological treatment AOHO combination was studied for the virus-bacterium interactions involved in element cycles by metaviromics, metagenomics and physicochemical characteristics. Results showed the unique viromic profile with Cirlivirales and Petitvirales as the dominant viruses infecting functional bacteria hosts.

Piezo1 Mediates Glycolysis-Boosted Pancreatic Ductal Adenocarcinoma Chemoresistance within a Biomimetic Three-Dimensional Matrix Stiffness.

Pancreatic ductal adenocarcinoma (PDAC) is a lethal cancer with a very low 5-year survival rate, which is partially attributed to chemoresistance. Although the regulation of chemoresistance through biochemical signaling is well-documented, the influence of three-dimensional (3D) matrix stiffness is poorly understood. In this study, gelatin methacrylate (GelMA) hydrogels were reconstructed with stiffnesses spanning the range from normal to cancerous PDAC tissues, which are termed as the soft group and stiff group.

Neural functions vary by return-to-sport status in participants with anterior cruciate ligament reconstruction: a retrospective cohort study using sub-bands of resting-state functional magnetic resonance.

Objective: This study aimed to characterize the differences in neural function among patients with different functional abilities 2 years after anterior cruciate ligament reconstruction (ACLR).

Design: Resting-state functional magnetic resonance imaging was performed to obtain blood-oxygen-level-dependent values for ACLR returned to sports coper participants (CP), non-coper participants (NP), and healthy controls (HC). The amplitude of low-frequency fluctuations (ALFF) and regional homogeneity (ReHo) calculated changes in the standard frequency band (SFB) (0.

An unsupervised online Tai Chi program for people with knee osteoarthritis ("My Joint Tai Chi"): Study protocol for the RETREAT randomised controlled trial.

Background: Knee osteoarthritis (OA) is a leading contributor to global disability, with exercise proven to be an effective treatment. Tai Chi is a recommended type of exercise, but it is primarily done in person which imposes an accessibility issue. This study aims to evaluate the effects of an online unsupervised program, when provided with online educational information and exercise adherence support, on changes in knee pain and physical function, when compared to online education control for people with knee OA.

Slit regulates compartment-specific targeting of dendrites and axons in the brain.

Proper functioning of the nervous system requires precise neuronal connections at subcellular domains, which can be achieved by projection of axons or dendrites to subcellular domains of target neurons. Here we studied subcellular-specific targeting of dendrites and axons in the mushroom body (MB), where mushroom body output neurons (MBONs) and local dopaminergic neurons (DAN) project their dendrites and axons, respectively, to specific compartments of MB axons. Through genetic ablation, we demonstrate that compartment-specific targeting of MBON dendrites and DAN axons involves mutual repulsion of MBON dendrites and/or DAN axons between neighboring compartments.

Ephrin-mediated dendrite-dendrite repulsion regulates compartment-specific targeting of dendrites in the central nervous system.

Neurons often forms synaptic contacts at specific subcellular domains to differentially regulate the activity of target neurons. However, how dendrites are targeted to specific subcellular domains of axons is rarely studied. Here we use mushroom body out neurons (MBONs) and local dopaminergic neurons (DANs) as a model system to study how dendrites and axons are targeted to specific subcellular domains (compartments) of mushroom body axonal lobes to form synaptic contacts.

Upconversion luminescence and thermosensitive properties of NaGd(PO):Yb/Er.

High-sensitivity optical temperature measurement has attracted extensive attention in both fundamental studies and practical applications. In this study, a series of upconversion (UC) luminescence phosphors composed of NaGd(PO) (NGP) doped with 20 at% Yb and various concentrations of Er (0.5 at% as the optimal concentration) was synthesized by high-temperature solid-state method.

Construction of a Cell Factory for the Targeted and Efficient Production of Phytosterol to Boldenone in Mycobacterium neoaurum.

Boldenone (BD), a protein anabolic hormone, is commonly used to treat muscle damage, osteoporosis, and off-season muscle building in athletes. Traditional BD synthesis methods rely on chemical processes, which are costly and environmentally impactful. Therefore, developing a more sustainable and economical biosynthetic pathway is crucial for BD production.

Promoting Piezoelectricity in Amino Acids by Fluorination.

Bioinspired piezoelectric amino acids and peptides are attracting attention due to their designable sequences, versatile structures, low cost, and biodegradability. However, it remains a challenge to design amino acids and peptides with high piezoelectricity. Herein, a high piezoelectric amino acid by simple fluorination in its side chain is presented.

Repetitive Transcranial Magnetic Stimulation: Is it an Effective Treatment for Cancer Pain?

Cancer is a major public health issue, with an estimated 20 million new cases and 9.7 million cancer-related deaths worldwide in 2022. Approximately 44.

Production of site-specific antibody conjugates using metabolic glycoengineering and novel Fc glycovariants.

Molecular conjugation to antibodies has emerged as a growing strategy to combine the mechanistic activities of the attached molecule with the specificity of antibodies. A variety of technologies have been applied for molecular conjugation; however, these approaches face several limitations, including disruption of antibody structure, destabilization of the antibody, and/or heterogeneous conjugation patterns. Collectively, these challenges lead to reduced yield, purity, and function of conjugated antibodies.

Neohesperidin protects against colitis-associated colorectal cancer in mice via suppression of the NF-κB/p65 and MAPK pathways.

Patients with inflammatory bowel disease (IBD) are at increased risk of developing colitis-associated colorectal cancer (CAC). Neohesperidin (NHP), a flavanone glycoside derived from citrus fruits, has been reported to have anti-inflammatory, antioxidant, and anticancer potential. However, the function of NHP on tumorigenesis has not been well understood.

Velocity Scanning Tomography for Room-Temperature Quantum Simulation.

Quantum simulation offers an analog approach for exploring exotic quantum phenomena using controllable platforms, typically necessitating ultracold temperatures to maintain the quantum coherence. Superradiance lattices (SLs) have been harnessed to simulate coherent topological physics at room temperature, but the thermal motion of atoms remains a notable challenge in accurately measuring the physical quantities. To overcome this obstacle, we implement a velocity scanning tomography technique to discern the responses of atoms with different velocities, allowing cold-atom spectroscopic resolution within room-temperature SLs.

A near infrared fluorescent probe for hypoxia based on dicyanoisophorone and its application in Hela cells imaging.

Hypoxia will accelerate tumors metastasis and deterioration, thereby limiting the effects of chemotherapy or radiotherapy. Thus, developing efficient techniques for detecting hypoxia in tumor cells is extremely important for cancer diagnosis and therapy. In this work, we reported a dicyanoisophorone-based probe (DCI-Azo) that specifically switched on its near infrared emission with hypoxia up-regulated azo-reductase (AzoR).

Evaluation of urban ecological livability and obstacle factor diagnosis from a synergistic perspective: A case study of Zhangjiajie City, China.

The construction of ecological livability plays a crucial role in achieving ecological civilization. During economic development, conflicts between urban populations, resources, and the environment have become increasingly prominent. Although China's efforts in building ecological livability have made certain achievements, they are still in the early stages, making research in this area very necessary.