Publications by authors named "Zhu P"

Background: Chronic inflammation and DNA methylation are potential mechanisms in dementia etiology. The linkage between inflammation and DNA methylation age acceleration in shaping dementia risk is understudied. We explored the association of inflammatory cytokines with cognitive impairment and whether DNA methylation age acceleration mediates this relationship.

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  • Bio-refining lignocellulosic resources is a sustainable method for producing biofuels and biochemicals, yet challenges exist in improving conversion efficiency for sugars like xylose and glucose.
  • Researchers engineered the bacterium Bacillus licheniformis to enhance acetoin production, achieving a 19.6% increase in output through adaptive evolution and advanced mutagenesis techniques.
  • The study successfully restructured the xylose uptake pathway, allowing for the co-utilization of xylose and glucose, which led to significant acetoin yields from both types of sugars and highlighted the biotechnological potential for creating valuable chemicals from lignocellulosic waste.
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  • Researchers synthesized and analyzed the structure of AgCu(CCAr)(PPh)Cl nanoclusters, which are composed of silver and copper and show unique absorbance features and superatomic properties.
  • Using single-crystal X-ray diffraction, they found that AgCu has an icosahedral metal core connected to tetrahedra, leading to impressive electrocatalytic performance in CO reduction, showing 95.26% efficiency and 257.2 mA cm at -1.3 V.
  • The study revealed that the high selectivity for CO stems from the removal of a ligand on the Ag atom, showcasing the benefits of using precise metal nanoclusters to explore the structure-performance relationships in catalysis.
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Traditional PEO electrolyte has high crystallinity which hinders the transmission of Li, resulting in poor ion conductivity and complicated processing technology. Herein, a polymer electrolyte (p-electrolyte) with a wide electrochemical window and high ionic conductivity is designed, which possesses an amorphous condensed structure. The amorphous structure provides fast transport channels for Li, so the p-electrolyte possesses an electrochemical window of 4.

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  • - This study investigates the clinical features and outcomes of elderly patients (≥60 years) compared to younger patients (<60 years) with acute pancreatitis (AP) and includes data from 2013 to 2019.
  • - Results show that elderly patients exhibit more severe symptoms and have significantly higher risks for death, organ failure, and infections, with age acting as an independent risk factor for poor outcomes.
  • - The mortality pattern in elderly patients differs from that in younger patients, with increased deaths occurring at specific times (first and fifth weeks), highlighting the need for tailored treatments to lower late mortality risks in older adults.
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  • Researchers studied the planthopper Nilaparvata muiri, which is closely related to the rice pest N. lugens, to explore their different host preferences and evolutionary adaptations.
  • They assembled a high-quality reference genome for N. muiri using advanced sequencing technologies, determining its size to be 531.62 Mb with a high level of completeness (98.6%).
  • The research identified over 22,000 protein-coding genes and significant repetitive sequences in the genome, making it a crucial resource for further studies on planthopper evolution and potential pest management strategies.
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Osteoporosis (OP) is a disorder of bone remodeling caused by an imbalance between bone resorption by osteoclasts and bone formation by osteoblasts. Therefore, inhibiting excessive osteoclast activity is one of the promising strategies for treating OP. A major transient receptor potential cation channel, known as transient receptor potential ankyrin 1 (TRPA1), was found to alleviate joint pain and cartilage degeneration in osteoarthritis.

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Background: Higher red blood cell distribution width (RDW) levels are associated with mortality in patients with chronic obstructive pulmonary disease (COPD). However, more convincing evidence is still lacking, and the relationship between hemoglobin-to-red blood cell distribution width ratio (HRR) and mortality in patients with COPD remains unclear.

Methods: This study is a prospective cohort study that includes 3,745 adult patients with COPD from the National Health and Nutrition Examination Survey (NHANES) database spanning from 1999 to 2018 in the United States.

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Paper-integrated configuration with miniaturized functionality represents one of the future main green electronics. In this study, a paper-based respiration sensor was prepared using a multiwalled carbon nanotube-templated nickel porphyrin covalent organic framework (MWCNTs@COF) as an electrical identification component and pencil-drawn graphite electric circuits as interdigitated electrodes (IDEs). The MWCNTs@COF not only inherited the high gas sensing performance of porphyrin and the aperture induction effect of COFs but also overcame the shielding effect between phases through the MWCNT template.

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, a distinctive Yi medicine, utilized the roots as an essential medicinal substance for trauma treatment of the "Yunnan Hong Yao". , however, cannot be cultivated artificially presently, and it has been described with a phenomenon of mixed utilization of roots and stems, impeding pharmaceutical quality control. In response to resource scarcity and standardization issues, the research comprehensively compares the material basis and efficacy of medicinal (roots) and non-medicinal (stems) parts by using chemical profiling and pharmacological methodologies.

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Cold stress detrimentally influences fruit development, leading to a substantial yield reduction in many fruit-bearing vegetables. Cucumber, a vegetable of subtropical origin, is especially sensitive to cold. Cold-inducible parthenocarpy (CIP) promises fruit yield under cold conditions.

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Heart failure is a multifactorial disease, the percentage of patients with heart failure caused by metabolic syndrome is increasing year by year. The effect of gut flora dysbiosis on metabolic syndrome and heart failure has received widespread attention in recent years. Drugs to treat the condition urgently need to be discovered.

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The behavior and fate of PFOS (perfluorooctanesulfonate) in the aquatic environment have received great attention due to its high toxicity and persistence. The nanoscale supramolecular mechanisms of interaction between PFOS and ubiquitous EPS (exopolymers) remain unclear though EPS have been widely-known to influence the bioavailability of PFOS. Typically, the exposure patterns of PFOS in aquatic animals changed with the EPS-PFOS interaction are not fully understood.

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The naked mole rat (NMR), Heterocephalus glaber, is known as the longest-lived rodent and is extraordinarily resistant to hypoxia and cancer. Here, both NMR embryonic fibroblasts (NEFs) and their mouse counterparts (MEFs) were subjected to anoxic conditions (0% O2, 5% CO2). A combination of comparative transcriptomics and proteomics was then employed to identify differentially expressed genes (DEGs).

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  • The study investigates the role of the uN2CpolyG protein, linked to NOTCH2NLC gene expansions, in causing cerebrovascular issues in patients with neuronal intranuclear inclusion disease (NIID), particularly focusing on cerebral microbleeds (CMBs).
  • Researchers examined 97 NIID patients using advanced imaging techniques and various staining methods on brain tissues, identifying a total of 354 CMBs mostly in deep brain areas.
  • Findings showed that while there were no significant differences in common cerebrovascular risk factors between patients with and without CMBs, those with CMBs had a higher incidence of previous stroke events and certain brain lesions, indicating a link between uN2CpolyG pathology and cerebral
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Background: Cognitive impairment is one of the major diseases facing the aging population. The progressive decline of cognitive function can lead to declining health or even the loss of life, work, and social ability. Exercise and behavioral stimulation can increase neurotransmitters in the brain and improve overall health and cognitive function.

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Promoting the Curie temperature ( ) and tunning the magnetocrystalline anisotropy energy (MAE) have been key issues with two-dimensional (2D) ferromagnetic (FM) materials. Here, the structural and magnetic properties of MnTe/X (X = As, Sb and Bi) heterostructures are investigated through first-principles calculations. We reveal that monolayer MnTe weakly interacts with monolayer As or Sb through van der Waals (vdW) forces, but has strong covalent bonds with monolayer Bi, indicated by Bi-Te bond formation.

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Soil fungi participate in various ecosystem processes and are important factors driving the restoration of degraded forests. However, little is known about the changes in fungal diversity and potential functions under the development of different vegetation types during natural (secondary forest succession) and anthropogenic (reforestation) forest restoration. In this study, we selected typical forest succession sequences (including Siebold & Zucc.

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The adhesion of bacteria to the surface leads to formation of biofilms causing numerous infection problems in implanting medical devices or interventional therapy. Traditional treatment for such problems is generally to administrate patients with antibiotics or antifungal agent. Alternatively, devices are taken out of the body to mechanically destroy the biofilm and re-used by surgery.

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Background Nail unit squamous cell carcinoma (nSCC) is a malignant subungual tumour. Although it has a low risk of metastasis and mortality, the tumour has a significant local recurrence rate. There is insufficient data to determine whether functional surgery is less effective than amputation for nSCC that does not involve the bone.

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In practical visual search fields, observers often encounter errors that result from an unknown number of targets, which may induce reduced accuracy and speed. Our current study addresses the potential enhancement of collaborative search efficiency as a dyad to mitigate such incurred search costs. Utilizing the capacity coefficient, we evaluated search efficiency and explored the interplay of task difficulty and termination rule in collaborative visual search.

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The growing interest in paper-based materials for packaging is driven by their renewable and eco-friendly characteristics. However, their poor barrier performance against water, oil, and gas limits their application in the food packaging industry. In this study, we developed a simple dual-layer coating method to create water- and oil-repellent, gas barrier, antioxidant, and antibacterial paper-based materials using naturally-derived materials, including chitosan (CS), ethyl cellulose (EC), and cascade biorefinery products from green walnut husk (GWHE and CNC).

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Herein, we present a Ni-catalyzed direct cross-coupling of heteroaromatic thioethers with aryl iodides via selective C(sp)-S bond cleavage under reductive conditions, thereby providing various biaryl frameworks with high efficiency. Mechanistic studies suggested Mo(CO) played a crucial role in facilitating the activation of the C(sp)-S bond. This protocol demonstrated a wide substrate scope, operational simplicity, and good functional group compatibility.

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Rest-activity behavior clusters within individuals to form patterns are of significant importance to their intrinsic capacity (IC), yet they have rarely been studied. A total of 1253 community-dwelling older adults were recruited between July and December 2021 based on the baseline survey database of the Fujian Prospective Cohort Study on Aging. Latent profile analysis was used to identify profiles of participants based on rest-activity behaviors, whereas logistic regression analysis was carried out to investigate the relationship between profiles and IC.

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