Design and Synthesis of Thioglycosylated Monolignol Dual Probes for Bioimaging of Lignin Biosynthesis.

Lignin biosynthesis is a critical process that underpins plant structural integrity and defenses. Central to this pathway are monolignol glucosides (MLGs), whose role as intermediates remains debated. To elucidate MLGs' involvement, we developed thioglycosylated monolignol probes compatible with click chemistry for in situ visualization of lignin biosynthesis.

l-Proline Enhanced Whole Ovary Cryopreservation by Inhibiting Ice Crystal Growth and Reducing Oxidative Stress.

Cryopreservation and transplantation of ovaries are considered to be effective methods for preserving the fertility of female cancer patients. However, ice crystal and oxidative damage occur during the freeze-thaw cycle, significantly reducing the effectiveness of cryopreservation and limiting its clinical application. Thus, new technologies or agents must be explored to enhance ovarian cryopreservation.

Erratum: AMPD3 promotes doxorubicin-induced cardiomyopathy through HSP90α-mediated ferroptosis.

[This corrects the article DOI: 10.1016/j.isci.

Bisphenol A impairs oocyte maturation by dysfunction of cumulus cells.

Bisphenol A (BPA) is a well-known environmental endocrine disruptor that has detrimental effects on reproduction. This study aimed to investigate whether BPA exposure could disrupt the function of cumulus cells and influence oocyte maturation and development. Porcine oocytes at the germinal vesicle stage were exposed to BPA for 44 h.

Rate adaptive compressed sampling based on region division for wireless sensor networks.

Image acquisition and transmission in wireless sensor networks (WSN) are core issues for some resource-deficient multimedia sensing applications. Reducing sampling rates and data transmission lowers sensor node costs and energy, addressing communication bottlenecks. Block compressed sampling (BCS) can meet the above requirements.

Respiratory delivery of single low-dose nebulized PFCE-C25 NEs for lymphatic transport and durable stimulation of antitumor immunity in lung cancer.

The currently available immune checkpoint inhibitors (ICIs) often fail to achieve the desired clinical outcomes due to inadequate immune activation, particularly in patients with lung cancer. To reverse this situation, we synthesized inhalable PFCE-C25 nanoemulsions (NEs), which target lymphocyte activation genes (LAG-3) on immune cells within tumor microenvironment and tumor-draining lymph nodes (TDLNs). By combining in vivo F-MR molecular imaging, we investigate the immunological effects of a single low-dose PFCE-C25 NEs in multiple murine lung cancer models, including human immune system (HIS) mouse models, and validated its immunological effects in human TDLNs.

In-Situ CeO/CuO Heterojunction Electrocatalyst for CO Reduction to Ethylene.

CeO/CuO heterojunction composite catalysts were synthesized using a one-step method, achieving the introduction of Ce species on nanoscale copper oxide (CuO) particles during the hydrothermal process. CeO is primarily encapsulated the auxiliary catalyst CuO in the form of nanoparticles. On one hand, this protects the nanostructure of the substrate from damage and prevents the agglomeration of CuO nanoparticles.

Impoundment-induced stoichiometric imbalance exacerbated phosphorus limitation in a deep subtropical reservoir: Implications for eutrophication management.

Impoundments play a vital role as nutrient sinks, capable of retaining and exporting nitrogen (N) and phosphorus (P) at different rates. The imbalance in N and P stoichiometry relative to phytoplankton demand often determines the limiting nutrient of phytoplankton biomass in these systems. This critical factor has a substantial impact on the management of eutrophication, encompassing the formulation of nutrient control strategies and the setting of regulatory thresholds.

Geochemical behavior of rare earth elements in mining-affected waters, southwest China.

Mining activities have led to significant rare earth elements (REEs) contamination and ecotoxicological risks in aquatic systems. However, the concentration, speciation, and primary controlling factors of REEs in aquatic systems in southwest China have remained unclear. This study investigated the water geochemistry, concentration, speciation, fractionation patterns, and anomalies of REEs in the surface water, shallow groundwater, and deep groundwater within a mining-impacted catchment area in southwest China across different seasons.

Data-driven models for forecasting algal biomass in a large and deep reservoir.

Early warning of algal biomass is important for the preservation and management of drinking water. However, accurate prediction of algal biomass in large and deep reservoirs remains a challenge. Here, we used six years of high-frequency observations (30 min/time) to train long short-term memory (LSTM) models for forecasting chlorophyll-a concentration (C) and column-integrated C (CIC) for a large and deep Chinese reservoir (Xin'anjiang Reservoir).

Impact of a Text Messaging Intervention as an In-Between Support to Diabetes Group Visits in Federally Qualified Health Centers: Cluster Randomized Controlled Study.

Background: In the United States, 1 in 11 people receive primary care from a federally qualified health center (FQHC). Text messaging interventions (TMIs) are accessible ways to deliver health information, engage patients, and improve health outcomes in the health center setting.

Objective: We aimed to evaluate the impact of a TMI implemented with a group visit (GV) intervention among patients with type 2 diabetes mellitus (T2DM) at FQHCs on patient-reported outcomes and clinical outcomes based on patient TMI engagement.

A Matched Design for Causal Inference With Survey Data: Evaluation of Medical Marijuana Legalization in Kentucky and Tennessee.

A concern surrounding marijuana legalization is that driving after marijuana use may become more prevalent. Survey data are valuable for estimating policy effects, however their observational nature and unequal sampling probabilities create challenges for causal inference. To estimate population-level effects using survey data, we propose a matched design and implement sensitivity analyses to quantify how robust conclusions are to unmeasured confounding.

Synthesis, Structural Characterization, and Electronic Structure Analysis of F-type Superatomic Molecules.

The investigation of bonding interactions between superatoms continues to be a largely unexplored area of study. In this study, we present the synthesis and characterization of two F-type superatomic molecules [AuAg(CHNOS)(DPPB)] and [AuAg(CHNS)(DPPM)] ( and for short, respectively). The overall structures were confirmed via X-ray crystallography, revealing the horizontal expansion of the biicosahedral AuAg yielding [AuAg(CHNOS)(DPPB)] and vertical expansion of the biicosahedral AuAg yielding [AuAg(CHNS)(DPPM)].

Association between platelet-to-high-density lipoprotein cholesterol ratio and future stroke risk: a national cohort study based on CHARLS.

Background: According to recent research, there is a considerable correlation between the severity of coronary artery disease and the platelet-to-high-density lipoprotein cholesterol ratio (PHR), which suggests that PHR is a potentially valuable inflammatory biomarker. However, the body of current research offers insufficiently strong evidence to clarify the connection between PHR and the incidence of stroke. Therefore, this study aims to elucidate any potential associations between PHR and stroke risk.

Novel Model of Childhood Appetitive Traits in Children with Obesity.

Background/objectives: Appetitive traits have a central role in energy intake and development of obesity. Child Eating Behavior Questionnaire (CEBQ) is a validated psychometric tool to measure appetitive traits in children. This study sought to assess the CEBQ factor structure in children with obesity.

Evaluation of cerebral perfusion heterogeneity by the electrical impedance tomography.

Purpose: The purpose of this study was to evaluate the ability of global inhomogeneity index (GI) and left-right asymmetry index (AI) based on electrical impedance tomography (EIT) to be used in assessing cerebral perfusion heterogeneity. The diagnostic value of these two indices in identifying abnormalities in the degree of cerebral perfusion heterogeneity was also explored.

Methods: In this study, Transcranial Doppler (TCD) was used as a control, and unilateral carotid artery was compressed to change the degree of heterogeneity of cerebral perfusion in 15 healthy volunteers.

Long-lasting, subtype-specific regulation of somatostatin interneurons during sensory learning.

Somatostatin (SST)-expressing inhibitory neurons are a major class of neocortical γ-amino butyric acid (GABA) neurons, where morphological, electrophysiological, and transcriptomic analyses indicate more than a dozen different subtypes. However, whether this diversity is related to specific roles in cortical computations and plasticity remains unclear. Here we identify learning-dependent, subtype-specific plasticity in layer 2/3 SST neurons of the mouse somatosensory cortex.

Lycorine ameliorates liver steatosis, oxidative stress, ferroptosis and intestinal homeostasis imbalance in MASLD mice.

Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common liver disease worldwide and few drugs are available for its treatment. Lycorine has effective anti-inflammatory and lipid-lowering effects, but the impact on MASLD is not fully understood. In this study, we intend to test the intervention effect of lycorine on MASLD.