Publications by authors named "Zhu Luo"

Li-ion batteries employing stoichiometric layered Li metal oxides as cathodes are now reaching the energy density limits due to single cationic redox chemistry. Lattice oxygen redox (LOR) has been discovered in these materials, as a high-energy-density paradigm observed in Li-rich materials. Nevertheless, the origin of this process is not understood, preventing the rational design of better cathode materials.

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  • The study examines the role of sulfur dioxide (SO) in the catalytic purification of hydrocarbons, highlighting its complex effects on adsorption and reaction pathways for volatile organic compounds (VOCs).
  • A specialized catalyst (Pt/OM CZO) was created to explore these effects, revealing that SO can both hinder and enhance hydrocarbon oxidation processes.
  • Key findings show that while SO can promote structures that limit propene oxidation by causing carbon build-up, it can also activate propane oxidation by enhancing adsorption, which is significant for developing efficient sulfur-tolerant catalysts.
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  • A first-in-human study evaluated HRS-1780, an oral medication targeting mineralocorticoid receptors, in healthy men to assess its safety and tolerability.
  • The study involved single and multiple ascending doses, revealing that HRS-1780 was well tolerated with mild adverse events and showed potential effects on systolic blood pressure and plasma levels of aldosterone and norepinephrine.
  • The results indicated HRS-1780 has a favorable safety profile and does not significantly prolong QTcF intervals, despite a limited sample size and short duration of the trial.
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  • * A novel "dual active sites" strategy was developed using graphitized carbon-loaded core-shell cobalt catalysts (Co@CoO-C), maintaining 100% efficiency in ozone decomposition across various humidity levels.
  • * This approach leverages metallic cobalt nanoparticles to enhance reactivity and minimizes moisture interference, also incorporating advanced 3D printing for robust catalyst structures.
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Objective: SHR-1703 is a novel humanized IgG1 monoclonal antibody with high IL-5 affinity and prolonged half-life, aiming to control eosinophil-related diseases. The study intended to evaluate pharmacokinetics, pharmacodynamics, immunogenicity, safety, and tolerability of SHR-1703 in healthy subjects.

Methods: A single-center, randomized, double-blind, placebo-controlled, single-dose escalation phase I study was conducted.

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  • The study focuses on developing efficient catalysts for oxidizing formaldehyde (HCHO) to improve indoor air quality, and reviews over 400 existing works in this field.
  • A machine learning (ML) framework was created to predict catalyst performance using a database of HCHO oxidation catalysts, analyzing 20 different descriptors and utilizing the eXtreme Gradient Boosting algorithm to achieve a high prediction accuracy.
  • The results identified specific catalysts (Pt/MnO and Ag/Ce-CoO) with excellent performance, emphasizing the importance of metal-support interactions, and showcasing ML's potential for enhancing catalyst design.
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  • * A new version called oxygen-vacancy-enriched ordered macroporous CeZrO catalyst (V-OM CZO) was created, significantly improving soot oxidation activity (with temperatures of 430 °C for V-OM CZO vs. 490 °C for OM CZO and 545 °C for powder CZO).
  • * The unique structure of V-OM CZO enhances contact with soot, while its oxygen vacancies generate reactive
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  • Graphdiyne (GDY)-based materials have promising applications in catalysis, energy, and environmental science due to their unique structures and adjustable electronic properties.
  • GDY/metal oxide hybrid materials enhance active sites, improve charge transfer, and optimize the behavior of intermediate species, making them particularly useful in energy conversion and environmental remediation.
  • The review explores the synthesis, characterization, and activation mechanisms of GDY/MOs, while also addressing current opportunities and challenges in this innovative field.
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Vaccines have proven effective in protecting populations against COVID-19, including the recombinant COVID-19 vaccine (Sf9 cells), the first approved recombinant protein vaccine in China. In this positive-controlled trial with 85 adult participants (Sf9 cells group: n = 44; CoronaVac group: n = 41), we evaluated the safety, immunogenicity, and protective effectiveness of a heterologous boost with the Sf9 cells vaccine in adults who had been vaccinated with the inactivated vaccine, and found a post-booster adverse events rate of 20.45% in the Sf9 cells group and 31.

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  • SO typically deactivates catalysts in heterogeneous catalytic oxidations, but it enhances propane catalytic oxidation in Pt-based catalysts, with the exact mechanism still debated.
  • This study identifies the in situ-formed (Pt-S-O)-Ti structure as crucial for Pt/TiO catalysts' ability to tolerate SO, attributed to strong hybridization between Pt 5d and S 3p orbitals facilitating charge transfer.
  • The (Pt-S-O)-Ti structure's active oxygen atom effectively adsorbs CH, improving combustion performance, which may inform the design of SO-tolerant catalysts for better economic and environmental outcomes.
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The increase in the styrene content in styrene-butadiene rubber (SBR) can improve the abrasion performance and cutting resistance of rubber, which has received attention in the tire industry. The fatigue performance is the main evaluation index of rubber materials applied to tires. In this study, the effect of the styrene content and its interaction with carbon black (CB) on the dynamic fatigue performance and mechanism of SBR were investigated.

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The contamination of drinking water by microbes is a critical health concern, underscoring the need for safe, reliable, and efficient methods to treat pathogenic microorganisms. While most sterilization materials are available in powder form, this presents safety risks and challenges in recycling. Herein, this study reports the preparation of an innovative copper oxide supported silver monolithic nanoarray mesh with abundant oxygen vacancies (Ag/CuO-V) by laser ablation.

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Background: Pramipexole dihydrochloride extended-release tablet is a novel long-acting form of non-ergot dopamine agonist indicated as one of main therapeutic approaches for Parkinson's disease. However, pharmacokinetic properties of extended-release pramipexole in healthy Chinese subjects remain unclear.

Methods: A single-center, randomized, open-label, two-period crossover, single-dose study was performed to investigate comparative pharmacokinetics and evaluate bioequivalence of 0.

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Background: Autotaxin (ATX) and lysophosphatidic acid (LPA) play an important role in pathogenesis of idiopathic pulmonary fibrosis (IPF). FTP-198 is an oral, novel and selective ATX inhibitor indicated for treating IPF. The study aimed to investigate the pharmacokinetics, pharmacodynamics, safety and tolerability of FTP-198 in healthy subjects.

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Catalytic ozone (O ) decomposition at high relative humidity (RH) remains a great challenge due to the catalysts poison and deactivation under high humidity. Here, we firstly elaborate the role of water activation and the corresponding mechanism of the promoted O decomposition over the three-dimensional monolithic molybdenum oxide/graphdiyne (MoO /GDY) catalyst. The O decomposition over MoO /GDY reaches up to 100 % under high humid condition (75 % RH) at room temperature, which is 4.

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Background: Inclisiran is a novel siRNA therapy that inhibits the synthesis of proprotein convertase subtilisin-kexin type 9 (PCSK9) by targeting the PCSK9 mRNA, consequently, decreases low-density lipoprotein cholesterol (LDL-C).

Objective: To assess the safety, PK and LDL-C lowering effects of inclisiran in the Chinese patients with elevated LDL-C despite treatment with maximally tolerated LDL-C lowering therapies.

Methods: Forty Chinese patients with hypercholesterolemia (LDL-C ≥100 mg/dL) who were on maximally tolerated statin were randomized to receive a single dose of either inclisiran sodium 100 or 300mg s.

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Background: The prognostic value of cytokeratin 19 fragment (CYFRA 21 - 1) and Ki67 in advanced non-small cell lung cancer (NSCLC) patients with wild-type epidermal growth factor receptor (EGFR) remains to be explored.

Methods: In this study, 983 primary NSCLC patients from January 2016 to December 2019 were retrospectively reviewed. Finally, 117 advanced NSCLC patients with wild-type EGFR and 37 patients with EGFR mutation were included and prognostic value of CYFRA 21 - 1 and Ki67 were also identified.

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Background And Aim: Severe acute pancreatitis (SAP) in patients progresses rapidly and can cause multiple organ failures associated with high mortality. We aimed to train a machine learning (ML) model and establish a nomogram that could identify SAP, early in the course of acute pancreatitis (AP).

Methods: In this retrospective study, 631 patients with AP were enrolled in the training cohort.

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Background: Imrecoxib is a novel and moderately selective cyclooxygenase-2 inhibitor with properties of anti-inflammation and alleviating pain, which is widely applied in osteoarthritis patients. The pharmacokinetic data supporting imrecoxib's rational use in elderly population are not available.

Purpose: The study aims to investigate the pharmacokinetics of imrecoxib and its main metabolites and explore the safety of imrecoxib in elderly healthy subjects.

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The in-depth mechanism on the simultaneous activation of O and surface lattice O on one active metallic site has not been elucidated yet. Herein, we report a strategy for the construction of abundant oxygen activation sites by rational design of Cu /TiO single atom catalysts (SACs). The charge transfer between isolated Cu and TiO support generates abundant Cu and 2-coordinated O sites in Cu -O-Ti hybridization structure, which facilitates the chemisorption and activation of O molecules.

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Introduction: An extrafine formulation of the inhaled corticosteroid beclometasone dipropionate (BDP) plus the long-acting β-agonist formoterol fumarate (FF) has been available for years via a pressurised metered-dose inhaler for the management of asthma and chronic obstructive pulmonary disease. More recently, the same extrafine BDP/FF formulation has become available in a multidose dry-powder inhaler (DPI) called the NEXThaler. The pharmacokinetics (PK) of BDP/FF via this DPI have previously been evaluated in a Caucasian population.

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Background: The association between body mass index (BMI) and mortality is controversial. Thus, the purpose of our research was to survey the association between BMI and postoperative 30-day mortality in brain tumor patients undergoing craniotomy.

Methods: This study analyzed data collected in a multicenter, cross-sectional study that consecutively and nonselectively collected data from a total of 18,642 patients undergoing craniotomy for tumors in the ACS NSQIP from 2012 to 2015.

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Activation of O is a crucial step in oxidation processes. Here, the concept of sp-hybridized C≡C triple bonds as an electron donor is adopted to develop highly active and stable catalysts for molecular oxygen activation. We demonstrate that the neighboring sp-hybridized C and Cu sites on the interface of the sub-nanocluster CuO/graphdiyne are the key structures to effectively modulate the O activation process in the bridging adsorption mode.

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Background: Recaticimab (SHR-1209, a humanized monoclonal antibody against PCSK9) showed robust LDL-C reduction in healthy volunteers. This study aimed to further assess the efficacy and safety of recaticimab in patients with hypercholesterolemia.

Methods: In this randomized, double-blind, placebo-controlled phase 1b/2 trial, patients receiving stable dose of atorvastatin with an LDL-C level of 2.

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Revealing the role of engineered surface oxygen vacancies in the catalytic degradation of volatile organic compounds (VOCs) is of importance for the development of highly efficient catalysts. However, because of various structures of VOC molecules, the role of surface oxygen vacancies in different catalytic reactions remains ambiguous. Herein, a defective Pt/TiO catalyst is proposed to uncover the different catalytic mechanisms of CH and CH combustion via experiments and theoretical calculations.

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