Activation of HIF-1α C-terminal transactivation domain promotes tubulointerstitial fibrosis through hexokinase 2-mediated metabolic reprogramming.

Background: The hypoxia-inducible factor-1α (HIF-1α), a master transcription factor for adaptive responses to hypoxia, possesses two transcriptional activation domains [TAD, N-terminal (NTAD) and C-terminal (CTAD)]. However, the exact effects of HIF-1α CTAD in chronic kidney disease (CKD) are poorly understood.

Methods: Here, two independent mouse models of hypoxia-induced CKD, including ischemia/reperfusion-induced kidney injury and unilateral ureteral obstruction-induced nephropathy, were established using HIF-1α CTAD knockout (HIF-1α CTAD) mice.

Satisfaction and its determinants of rural upper gastrointestinal cancer screening in China: a preliminary cross-sectional study.

Objectives: To assess participants' satisfaction with and predictors of upper gastrointestinal cancer screening in rural areas.

Design: Cross-sectional study.

Setting: Ten screening centres in seven cities across five provinces in China.

Berberine Protects Secondary Injury in Mice with Traumatic Brain Injury Through Anti-oxidative and Anti-inflammatory Modulation.

Traumatic brain injury (TBI) is one of the major causes of death and disability worldwide. Novel and effective therapy is needed to prevent the secondary spread of damage beyond the initial injury. The aim of this study was to investigate whether berberine has a neuroprotective effect on secondary injury post-TBI, and to explore its potential mechanism in this protection.

[Selection of epidemic indicators for schistosomiasis GIS platform in Dongting Lake area].

Dongting Lake area is one of the major marshland schistosomiasis endemic areas in China. In recent years, spatial epidemiology is widely used in the research of schistosomiasis, which is a new opportunity to break through the current wandering situation of schistosomiasis control. In this article, both the generalized and Dongting-Lake-specific epidemic indicators of schistosomiasis are reviewed to provide the basis to construct the schistosomiasis Geographic Information System (GIS) database of Hunan Province.

[Strategy and effect of schistosomiasis emergency control after earthquake in Lushan County].

Objective: To evaluate the effects of measures on the schistosomiasis control after the earth quake in Lushan County, so as to provide the experiences for post-disaster schistosomiasis control.

Methods: The measures taken in schistosomiasis control after the earth quake were reviewed in Lushan County in 2013, and the epidemic situation of schistosomiasis was investigated and the results were analyzed.

Results: The schistosomiasis control in floating population and the control of Oncomelania hupensis snails were enhanced, and no schistosome infections were found in both human and livestock.

[Analysis of epidemiological characteristics of advanced schistosomiasis in Hu-nan province, 2012].

Objective: To understand the epidemiological characteristics of patients with advanced schistosomiasis in Hunan Province, so as to provide the evidence for formulating the advanced schistosomiasis prevention strategies and measures.

Methods: The data of advanced schistosomiasis patients were collected and analyzed retrospectively with the cross section research method and description method in Hunan Province, 2012.

Results: There were 5 722 advanced schistosomiasis patients in Hunan Province, and among them, 4 112 patients were male (71.

[Investigation and treatment of newly discovered advanced schistosomiasis cases in Hunan Province in 2011].

Objective: To understand the epidemiological characteristics and current status of newly confirmed advanced schistosomiasis patients in Hunan Province in 2011.

Methods: The cases previously diagnosed or suspected as advanced schistosomiasis in Hunan Province were the subjects of this investigation. Questionnairing (demographical information, disease history, etc.

Extremely large volume electrokinetic stacking of cationic molecules in MEKC by EOF modulation with strong acids in sample solutions.

In this report, a novel facile way of online preconcentration of trace levels of analytes in capillary electrophoresis is presented. The proposed strategy is based on the combination of strong acidic phosphate as sample buffers with borate separation buffer containing sodium dodecyl sulfate. When injection voltage is applied, the continuous introduction of low pH sample causes the apparent bulk flow inside the capillary gradually slows down.

The combination of flow injection with electrophoresis using capillaries and chips.

The technique of combined flow injection CE (FI-CE) integrates the essential favorable merits of FI and CE. It utilizes the various excellent on-line sample pretreatments and preconcentration (such as cloud point extraction, SPE, ion-exchange, dynamic pH junction and head-column field-amplified sample stacking technique) of FI, which has the advantages of high speed, accuracy, precision and avoiding manual handling of sample and reagents. Therefore, the coupling of FI-CE is an attractive technique; it can significantly expand the application of CE and has achieved many publications since its first appearance.

[Analysis of hydrogen bondings in polyurethane urea cured in graded temperature field by FTIR].

Hydrogen bondings in polyurethane urea elastomer, which reflect the microphase separation, have an important effect on the properties of the elastomer. The polyurethane urea elastomers, whose degree of microphase separation changed gradually, were prepared in the graded temperature field. Hydrogen bondings in them were investigated by FTIR technology.

Influence of ultrasonic cavitation on passive film of stainless steel.

The electrochemical behaviors of passive film of stainless steel 0Cr13Ni5Mo under the condition of static state (quiescence) and ultrasonic cavitation in the HCl solution have been studied by means of polarization curve, electrochemical impedance spectroscopy (EIS) and capacitance potential measurement. The results indicate that the passive film shows a multi layer structure distribution, and presents a p-type semiconductor property under the condition of quiescence. The stability of passive film decreases, the semiconducting property changes to an n-type semiconductor in the presence of cavitation.