Publications by authors named "Zhu Jiang"

Human papillomavirus (HPV) screening is vital for the early detection and prevention of cervical cancer. However, existing methods often face challenges related to speed, simplicity, and multiplexing, especially in resource-limited settings. Here we developed a portable SlipChip-based multiplexed and rapid nucleic acid testing platform, named SMART, designed to simultaneously detect HPV16 and HPV18.

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Objective The purpose of this study was to establish the efficacy of ultrasound (US)-guided hydrodilatation of the glenohumeral joint, in conjunction with corticosteroid injection, in alleviating pain and improving shoulder joint adhesion among patients with primary frozen shoulder (FS). Background: FS, also known as adhesive capsulitis, is a pathological condition characterized by pain and potential functional impairment. The natural progression of FS involves three distinct stages: freezing, frozen, and thawing.

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Glioblastoma multiforme (GBM), a highly prevalent and lethal form of malignant tumor, is typically treated with Temozolomide (TMZ), a chemotherapeutic agent. Nevertheless, the effectiveness of TMZ is hampered by inadequate cell entry, systemic adverse effects, and monotherapy constraints. Previous clinical studies have demonstrated that combination therapy can significantly enhance the therapeutic efficacy.

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With the development of society and economy, and the improvement of people's living standards, obesity has gradually become a significant issue not only in China but globally. Epidural anesthesia, being the most commonly used method for labor analgesia in clinical practice, has significantly reduced the pain experienced by parturients during childbirth and decreased the cesarean delivery rate. However, due to the anatomical and physiological differences between obese and non-obese parturients, the effectiveness and techniques of labor analgesia may vary.

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Background: Autism spectrum disorder (ASD) is a lifelong condition. It is characterized by complex etiologies, including disruptions in exogenous retinoic acid (RA) signaling, which may serve as an environmental risk factor. Targeting the RA pathway presents a promising therapeutic avenue, though the precise mechanisms remain to be elucidated.

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Objectives: Expanded carrier screening (ECS) is a preventive genetic test that enables couples to know their risk of having a child affected by certain monogenetic diseases. This study aimed to evaluate the carrier frequency for rare monogenic diseases in the general Chinese population and the impacts of ECS on their reproductive decisions and pregnancy outcomes.

Methods: This single-center study was conducted between September 2022 and April 2023.

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Respiratory syncytial virus (RSV) and human metapneumovirus (hMPV) cause human respiratory diseases and are major targets for vaccine development. In this study, we design uncleaved prefusion-closed (UFC) trimers for the fusion protein (F) of both viruses by examining mutations critical to F metastability. For RSV, we assess four previous prefusion F designs, including the first and second generations of DS-Cav1, SC-TM, and 847A.

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Furanocoumarins are a class of chemical compounds with phototoxic properties. For herbivores, efficient detoxification of such defense compounds is the prerequisite to feed successfully on furanocoumarin-containing plants. The cotton bollworm Helicoverpa armigera is a very important polyphagous pest in agriculture, but how it copes with toxic furanocoumarins in some of its host plants is not well understood.

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  • Peripheral nerve injuries pose significant challenges for treatment due to the shortage of available autologous grafts, but using functional hydrogels can provide effective alternatives for patient care.
  • This research introduces a new hydrogel made from a modified chitosan derivative, combined with sodium alginate and polypyrrole, which shows impressive thermal stability and tunable properties for nerve repair applications.
  • By adjusting the components and ratios in the hydrogel, it was found that optimal conditions resulted in strong electrical conductivity and promising sciatic function index values, indicating potential effectiveness in nerve regeneration.
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  • Cystic Echinococcosis (CE) is a disease caused by the parasite Echinococcus granulosus, leading to liver damage, and there is a concern that certain immune responses can worsen this condition.
  • This study investigated how the hormone Ghrelin affects the progression of liver lesions in mice infected with E.g, examining serum levels, local expression around lesions, and cellular responses to Ghrelin.
  • Results showed increased Ghrelin levels in E.g-infected mice at earlier stages, significant interaction with immune cells, and Ghrelin's ability to suppress inflammatory and fibrotic responses while blocking its receptor hindered the growth of infected cells in lab tests.
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  • - Genital herpes, mainly caused by herpes simplex virus type 2 (HSV-2), remains a global health issue, with a need for more understanding of immune responses in affected patients.
  • - Research using single-cell RNA sequencing on immune cells from both healthy people and recurrent genital herpes patients revealed the involvement of various immune cells and significant gene expression related to inflammation and antiviral responses.
  • - The findings suggest that the reactivation of HSV-2 might impact the functionality of circulating immune cells, opening up possibilities for further studies into the role of systemic immunity in HSV infections and recurrences.
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  • Adenomatoid tumors are rare, benign tumors in the reproductive tract, originating from mesenchymal tissue, making diagnosis challenging.
  • A case study involved a patient whose previously diagnosed uterine fibroid significantly increased in size over a year, leading to further imaging that suggested a borderline tumor.
  • Combining ultrasound and MRI can greatly enhance the accuracy of diagnosing uterine adenomatoid tumors, and the article highlights key imaging features for clinicians.
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The development of an effective and broadly protective influenza vaccine against circulating and emerging strains remains elusive. In this study, we evaluated a potentially universal influenza vaccine based on single-component self-assembling protein nanoparticles (1c-SApNPs) presenting the conserved matrix protein 2 ectodomain (M2e) from influenza A and B viruses (IAV and IBV, respectively). We previously designed a tandem antigen comprising three IAV M2e domains of human, avian/swine, and human/swine origins (termed M2ex3).

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In order to enhance the accuracy and adaptability of urban water supply pipeline leak localization, based on the Northern Goshawk Optimization, a novel joint denoising method is proposed in this paper to reduce noise in negative pressure wave signals caused by leaks. Firstly, the Northern Goshawk Optimization optimizes the decomposition levels and penalty factors of Variational Mode Decomposition, and obtains their optimal combination. Subsequently, the optimized parameters are used to decompose the pressure signals into modal components, and the effective components and noise components are distinguished according to the correlation coefficients.

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Paleoclimate model simulations provide reference data to help interpret the geological record and offer a unique opportunity to evaluate the performance of current models under diverse boundary conditions. Here, we present a dataset of 35 climate model simulations of the warm early Eocene Climatic Optimum (EECO; ~ 50 million years ago) and corresponding preindustrial reference experiments. To streamline the use of the data, we apply standardised naming conventions and quality checks across eight modelling groups that have carried out coordinated simulations as part of the Deep-Time Model Intercomparison Project (DeepMIP).

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  • The study examined how shrub encroachment affects the population characteristics and soil factors in the Xilingol Grassland of Inner Mongolia at different stages (light, moderate, severe).
  • Results indicated that both density and height of shrubs increased significantly from light to moderate stages, with moderate stage showing the highest competition among herbaceous species.
  • Soil conditions varied across encroachment stages, with light encroachment showing minimal impact, while moderate to severe stages revealed soil moisture and pH as critical limiting factors for shrub growth and expansion.
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  • The study discusses the development of injectable hydrogels as an alternative to cartilage implantation, addressing issues with donor scarcity and slow healing rates.
  • The hydrogels are made by modifying chitosan and using a combination of UV-triggered reactions and metal coordination for fast cross-linking.
  • Results show that these hydrogels are not only biodegradable and self-healing but also biocompatible, with potential to improve motor function in mice, thereby offering a promising solution for cartilage repair.*
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Cystic echinococcosis (CE) is a zoonotic disease caused by the parasite (), which can lead to the formation of liver lesions. Research indicates that releases both Toll-like receptor 2 (TLR2) and Interleukin-9 (IL-9), which can potentially impair the body's innate immune defenses and compromise the liver's ability to fight against diseases. To investigate the role of TLR2 and IL-9 in liver damage caused by infection, samples were initially collected from individuals diagnosed with CE.

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Optical coherence tomography angiography (OCTA), a functional extension of optical coherence tomography (OCT), is widely employed for high-resolution imaging of microvascular networks. However, due to the relatively low scan rate of OCT, the artifacts caused by the involuntary bulk motion of tissues severely impact the visualization of microvascular networks. This study proposes a fast motion correction method based on image feature matching for OCT microvascular images.

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Hepatobiliary-specific magnetic resonance imaging contrast agents (MRI CAs) play a crucial role in the early diagnosis of hepatocellular carcinoma (HCC). However, only two acyclic CAs, Gd-BOPTA and Gd-EOB-DTPA, exhibit unfavorable kinetic inertness. Our study focused on the development of superior stable innovative macrocyclic CAs.

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Background: Schistosomiasis is still one of the most serious parasitic diseases. Evidence showed that the metabolite profile in serum can potentially act as a marker for parasitic disease diagnosis and evaluate disease progression and prognosis. However, the serum metabolome in patients with Schistosoma japonicum infection is not well defined.

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In the past few decades, great progress has been made in prenatal diagnosis of congenital heart disease (CHD). Fetal echocardiography is recognized as the main prenatal screening and diagnostic tool that can accurately detect approximately 85 % of fetal cardiac abnormalities. Evaluation of the fetal heart remains a major challenge in prenatal ultrasound screening and diagnosis due to fetal position, involuntary movement, small and complex fetal cardiac anatomy, maternal abdominal wall conditions, and lack of expertise in fetal echocardiography by some physicians engaged in obstetric ultrasound.

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