Publications by authors named "Zhu Haitao"

Eugenol, a phenolic natural product with diverse pharmacological activities, remains unexplored in liver cancer. Using network pharmacology, we investigated eugenol's therapeutic mechanisms in liver cancer. We obtained eugenol's molecular structure from PubChem and screened its targets using similarity ensemble approach in Swiss Target Predictiondatabases.

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Polymer electrolytes incorporated with fillers possess immense potential for constructing the fast and selective Li conduction. However, the inhomogeneous distribution of the fillers usually deteriorates the microdomain consistency of the electrolytes, resulting in uneven Li flux, and unstable electrode-electrolyte interfaces. Herein, we formulate a solution-process chemistry to in situ construct gel polymer electrolytes (GPEs) with well-dispersed metal-organic frameworks (MOFs), leading to a uniform microdomain structure.

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The host-guest recognition system is incorporated into the core region of the 10-23 DNAzyme for precise regulation of its functionality. Biochemical experiments demonstrate reversible and orthogonal control of the DNAzyme function using cucurbit(7)uril and its competitive guests. Furthermore, cellular experiments indicate the gene expression can be effectively manipulated through this ligand-controllable DNAzyme.

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Purpose: To investigate the utility of combined tumour and lymph node (LN) radiomics features in predicting disease-free survival (DFS) among patients with locally advanced esophageal squamous cell carcinoma (ESCC) after neoadjuvant chemotherapy and resection.

Methods: We retrospectively enrolled 176 ESCC patients from January 2013 to December 2016. Tumour and targeted LN segmentation were performed on venous phase CT images.

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Background: Minimally invasive surgeries are increasingly central to modern medicine, particularly in liver transplantation. These techniques, which offer reduced trauma, precise operations, minimal bleeding, and swift recovery, are, however, unevenly adopted across China. Only a limited number of centers routinely perform minimally invasive donor hepatectomies, indicating a significant imbalance in the development and application of these advanced procedures.

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Background: This research aimed to delve into the cortical morphological transformations in patients with magnetic resonance imaging (MRI)-negative temporal lobe epilepsy (TLE-N), seeking to uncover the neuroimaging mechanisms behind these changes.

Methods: A total of 29 individuals diagnosed with TLE-N and 30 healthy control participants matched by age and sex were selected for the study. Using the surface-based morphometry (SBM) technique, the study analyzed the three-dimensional-T1-weighted MRI scans of the participants' brains.

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Aqueous proton batteries are attracting increasing attention in the large-scale next-generation energy storage field. However, the electrode materials for proton batteries often suffer from low specific capacity and unsatisfactory cycle durability. Herein, we synthesize two highly crystalline and robust polyimide covalent organic frameworks (COFs) through a solvent-free flux synthesis approach with benzoic acid as a flux and catalyst.

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A non-platinum-metal decanuclear complex [NiL(CHCOO) (CHOH)]·8(CHOH) (Ni complex) has been developed with a tri-dentate 2,3-dihydroxybenzaldehyde-2-aminophenol Schiff base ligand (HL). Single crystal X-ray analysis reveals that the Ni complex displays a sandwich loaf-shaped decanuclear structure and its anticancer activity was evaluated. The cell cytotoxicity results indicating that the Ni complex is most effective to human breast cancer cells MDA-MB-231 and its mechanism were further investigated.

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Natural killer (NK) cells, initially identified for their rapid virus-infected and leukemia cell killing and tumor destruction, are pivotal in immunity. They exhibit multifaceted roles in cancer, viral infections, autoimmunity, pregnancy, wound healing, and more. Derived from a common lymphoid progenitor, they lack CD3, B-cell, or T-cell receptors but wield high cytotoxicity via perforin and granzymes.

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Article Synopsis
  • Researchers are exploring ways to boost the antitumor activity of natural killer (NK) cells using interleukin-15 (IL-15), but concerns exist regarding potential toxicity and the risk of promoting cancers or autoimmune diseases.
  • A new platform called IL15RB has been developed, allowing IL-15 to be tethered to its receptor, leading to indefinite NK92 cell expansion without the need for additional cytokines.
  • Results indicate that NK92 cells expressing IL15RB show enhanced anticancer effects and resistance to certain treatments, though exposure to TGFβ1 diminishes their killing ability, highlighting the importance of addressing this in immunotherapy strategies.
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Existing metabolomic clocks exhibit deficiencies in capturing the heterogeneous aging rates among individuals with the same chronological age. Yet, the modifiable and non-modifiable factors in metabolomic aging have not been systematically studied. Here, a new aging measure-MetaboAgeMort-is developed using metabolomic profiles from 239,291 UK Biobank participants for 10-year all-cause mortality prediction.

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Unlabelled: The stigma exsertion rate (SER) is a key trait for the outcrossing ability of hybrid rice, which directly affects the yield of hybrid seeds in hybrid seed production. In previous studies, we have located 18 QTLs for SER using single-segment substitution lines in rice. In this study, we found that 4 of 18 QTLs for SER controlled stigma size (SS).

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  • A specific type of regulatory B cells in newborns (nBreg) uses IL-10 to limit the production of IgM antibodies, which helps control the immune response after initial activation.
  • *By analyzing these nBreg cells in fetal and neonatal intestines, researchers identified their antibody repertoire and demonstrated that they produce antibodies that react to various bacteria in the early microbiota.
  • *This study suggests that nBreg populations are crucial for shaping the microbiome during early life by influencing bacterial diversity and metabolism.*
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Objective: To compare the effectiveness of robot-assisted (RA) minimally invasive surgery versus traditional fluoroscopy-assisted (FA) open posterior fixation surgery in treating thoracolumbar fractures with ankylosing spondylitis (AS).

Methods: A clinical data of 21 cases of thoracolumbar fractures with AS who met the selection criteria between December 2016 and December 2023 was retrospectively analyzed. Ten cases underwent RA minimally invasive surgery group (RA group) and 11 cases underwent FA open posterior fixation surgery (FA group).

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Epistasis is one of important genetic components for a quantitative trait in plant. Eshed and Zamir found negative epistatic interactions of quantitative trait loci in Tomato first. We detected that positive (negative) QTLs generated mostly negative (positive) epistatic interactions on heading date in rice, and then proposed the hypothese that QTL epistasis plays a role of homeostasis in one of our recent papers.

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Introduction: Immune factors are important antecedents in the pathophysiology of necrotizing enterocolitis (NEC). However, studies on the peripheral blood lymphocyte subsets changes in NEC patients among different Bell stages and in patients requiring surgery are scarce.

Methods: 34 infants with NEC and 33 age-matched controls were included.

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  • Liver cancer is a common global issue, and donafenib, a newly approved drug, shows strong promise as a treatment due to its ability to inhibit tumor growth and promote cell death in liver cancer cells.
  • Research findings indicate that donafenib causes significant DNA damage and downregulates the PARP1 protein, which is linked to poor patient outcomes.
  • Combining donafenib with a PARP1 inhibitor enhances DNA damage and increases cell apoptosis compared to either treatment alone, suggesting a potential new therapy for liver cancer.
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  • The study develops machine learning models to predict lymph node metastases in advanced gastric cancer patients using CT images before and after treatment.
  • A total of 158 patients were analyzed, with results showing that the radiomics model performed better than traditional CT assessments in both training and testing groups, achieving area under the curve (AUC) scores of around 0.84.
  • The radiomics model demonstrated higher sensitivity and specificity than conventional CT methods, particularly for identifying patients without lymph node metastasis (N0 cases).
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  • Ferroptosis is a form of regulated cell death that relies on iron and is linked to various diseases.
  • Amino acids play a vital role in controlling ferroptosis by helping maintain balance in iron, lipids, and redox levels.
  • The effects of amino acids on ferroptosis can vary based on the situation, suggesting potential for new clinical therapies that focus on how amino acids influence this cell death process.
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Background And Objective: Minimally invasive surgery (MIS) has been widely utilized to manage congenital gastrointestinal (GI) anomalies in children during the last two decades. Currently, MIS has a proven track-record for its feasibility and provides multiple benefits including better cosmesis, less trauma, and faster recovery in neonates and infants. However, it remains controversial whether MIS provides better definitive outcomes in pediatric patients with GI anomalies, especially among neonates.

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  • Spontaneous intestinal perforation (SIP) is a serious condition that affects very young babies born early, especially in China.
  • In a study of 15,814 preterm infants, only 150 developed SIP, and many of them faced serious health problems or died while in the hospital.
  • Babies with SIP had a lower chance of surviving without major health issues than those without SIP, and most of the affected babies needed surgery to try to help them.
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  • * It involves the release of damage-related signals via autophagy, supporting the immune system's adaptive and innate responses.
  • * The article discusses how ferroptosis affects various immune and tumor cells in the tumor microenvironment, impacting cancer development and treatment outcomes.
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  • - Cancer stem cells (CSCs) play a significant role in tumor growth and treatment resistance due to their abilities to self-renew and differentiate in multiple ways.
  • - Recent research highlights iron metabolism as a crucial factor influencing the behavior and development of CSCs, impacting cancer prognosis and treatment outcomes.
  • - The review discusses advancements in understanding iron's role in CSCs, challenges in conventional treatments targeting iron, and potential new therapies to combat resistant cancers.
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  • Oxidative cross-coupling is a method for creating C-heteroatom bonds, but forming C-S bonds is difficult due to issues like sulfur overoxidation and metal catalyst poisoning.
  • A new approach using electrochemical redox relay has been developed, utilizing sulfur radicals from inorganic sources to facilitate the C-S bond formation with quinoxalinones and ammonium thiocyanate.
  • This method enables effective reactions without transition-metal catalysts, achieving good yields in a variety of quinoxalinone derivatives, paving the way for new pharmaceuticals or compounds with quinoxalinone cores.
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